Advair® HFA Inhaler for Asthma

Advair® HFA Inhaler combines fluticasone propionate and salmeterol to control persistent asthma. This page explains dosing, safety, strengths, and how to order from Canada at Canadian pricing. We ship to the US with US delivery from Canada, and cash-pay orders without insurance are supported.

What Advair® Is and How It Works

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic. Advair HFA is a combination inhaler with two medicines. Fluticasone is an inhaled corticosteroid that reduces airway inflammation. Salmeterol is a long-acting beta2-agonist that relaxes airway muscles to improve airflow.

This maintenance inhaler helps prevent symptoms such as wheeze, cough, and chest tightness. It is not a rescue medicine and will not treat sudden breathing trouble. A short-acting beta-agonist should be used for quick relief as directed by a clinician.

Who Advair® Is For

Advair HFA is indicated for the treatment of asthma in adults and adolescents 12 years and older. It supports long-term control in patients who are not adequately managed on an inhaled corticosteroid alone or who need combination therapy.

Advair HFA is not indicated for COPD. For COPD maintenance, clinicians may prescribe other therapies, such as a long-acting muscarinic antagonist like Spiriva® Respimat Inhaler, if appropriate. For asthma-focused product browsing, see our Asthma category.

Advair HFA should not be used to treat acute bronchospasm. It is contraindicated in patients with severe hypersensitivity to any component. Use caution in patients with active or latent infections, including tuberculosis, or in those with cardiovascular disease, arrhythmias, hyperthyroidism, diabetes, or seizure disorders.

Dosage and Usage

The typical schedule is two inhalations by mouth twice daily, about 12 hours apart. The prescribed strength depends on asthma severity and prior therapy. Do not exceed two inhalations twice daily of the assigned strength. Rinse the mouth with water after use and spit to reduce the risk of oral thrush.

Prime the inhaler before first use. Re-prime if it has not been used for several weeks or after the device is dropped, following the package insert. Shake well before each use. This inhaler is not for acute relief. A short-acting reliever, such as Ventolin® HFA Inhaler, is typically used for quick symptom rescue as directed by a clinician.

Always follow the FDA-approved label and your prescriber’s instructions for initiation, step-up or step-down, and device technique.

Strengths and Forms

Advair HFA is an aerosol metered-dose inhaler with these common strengths per actuation:

• 45/21 mcg (fluticasone propionate/salmeterol)
• 115/21 mcg
• 230/21 mcg

Many canisters provide 120 actuations and include a dose counter. Availability may vary by pharmacy and lot. If a dry powder device is preferred, the same active ingredients are available in a breath-actuated format as Advair® Diskus, which has different indications and dosing.

Missed Dose and Timing

If a dose is missed, take it when remembered unless it is near the next scheduled time. In that case, skip the missed dose and resume the regular schedule. Do not take extra inhalations to make up for a missed dose.

Storage and Travel Basics

Store the inhaler at room temperature and keep it dry. Avoid freezing or excessive heat. Do not puncture or incinerate the pressurized canister. Replace the mouthpiece cap after each use. Clean the mouthpiece regularly as directed in the package insert, typically by wiping with a dry cloth.

When you travel, keep the inhaler in carry-on baggage. Use a protective cap to keep the mouthpiece clean. Bring a copy of your prescription and pack extra supplies. Do not expose the canister to direct sunlight or enclosed hot spaces, such as a parked car.

Benefits

• Two-in-one controller: anti-inflammatory action from fluticasone plus bronchodilation from salmeterol.
• Helps reduce day and night asthma symptoms with scheduled twice-daily use.
• Metered-dose aerosol format is familiar and can work with a valved holding chamber if recommended.
• Multiple strengths allow stepwise adjustment under clinician guidance.
• Built-in dose counter helps track remaining actuations.

Side Effects and Safety

• Hoarseness or voice changes
• Sore throat or throat irritation
• Oral thrush (candidiasis)
• Headache
• Cough
• Tremor or nervousness
• Palpitations
• Nausea
• Sinus irritation

Serious or rare risks include paradoxical bronchospasm, immediate hypersensitivity reactions, adrenal suppression with high or prolonged corticosteroid exposure, decreased bone mineral density, glaucoma or cataracts, effects on growth in adolescents, arrhythmias, and changes in potassium or blood glucose. Long-acting beta-agonists increase the risk of asthma-related events when used without an inhaled corticosteroid; Advair HFA contains both agents in one inhaler. Seek urgent care for severe breathing trouble, swelling, hives, or chest pain.

Drug Interactions and Cautions

• Strong CYP3A4 inhibitors (for example, ketoconazole, ritonavir, cobicistat) can increase steroid and LABA exposure.
• Other long-acting beta2-agonists should not be used with salmeterol-containing products.
• Nonselective beta-blockers may reduce bronchodilatory effect.
• Diuretics that lower potassium can increase the risk of hypokalemia.
• Use caution with MAO inhibitors or tricyclic antidepressants due to potential cardiovascular effects.
• Use carefully in patients with cardiovascular disease, hyperthyroidism, diabetes, seizure disorders, or active infections including tuberculosis.

Always provide clinicians with a full medication and supplement list, including inhalers and over-the-counter products.

What to Expect Over Time

Many patients notice improved airflow and fewer symptoms within the first days to weeks. Full benefit often needs consistent twice-daily use. If asthma is not adequately controlled after a reasonable trial, clinicians may adjust the strength, check inhaler technique, or consider a different regimen.

Asthma care also includes trigger reduction, vaccinations as appropriate, and a written action plan. For background reading on asthma flare patterns, see our editorial on Asthma Attacks.

Compare With Alternatives

Other combination controllers include Symbicort® (budesonide/formoterol) and Trelegy® Ellipta (fluticasone/umeclidinium/vilanterol) for appropriate patients. Advair Diskus is a dry powder option for certain indications. Therapy choices depend on diagnosis, age, device preference, and prior response.

Pricing and Access

Canadian pricing can mean meaningful savings compared with typical US cash pay. You can check the Advair HFA Inhaler price, see current availability, and place your order online. Many patients search for terms such as Buy Advair HFA Inhaler online from Canada, Advair HFA Inhaler ships to US, and Advair HFA Inhaler price without insurance. We support self-pay orders and secure checkout with US shipping.

Strengths commonly listed include Advair HFA 45/21 mcg, Advair HFA 115/21 mcg, and Advair HFA 230/21 mcg. Listings may also note Advair HFA aerosol inhaler 120 actuations and Fluticasone/Salmeterol HFA Inhaler 115/21 mcg or 230/21 mcg. If you compare options, you may also look for Advair HFA 115/21 mcg inhaler price and Canadian Advair HFA Inhaler pricing. To stay updated on site deals, visit our Promotions page. Checkout uses encrypted processing.

You can schedule an Advair HFA Inhaler refill from Canada once your prescription is on file. We provide prompt, express shipping for US delivery from Canada.

Availability and Substitutions

Availability can vary by strength. If a specific strength is out of stock, a prescriber may recommend a different strength or a suitable alternative. Substitutions should match the diagnosis, age, and treatment goals. Do not switch devices or strengths without prescriber guidance.

Patient Suitability and Cost Saving Tips

Good candidates are adolescents and adults with persistent asthma who need combination controller therapy. Patients with severe milk protein allergy, status asthmaticus, or hypersensitivity to components should avoid use. Those with active infections, adrenal suppression, glaucoma, cataracts, osteoporosis, or significant heart disease require careful monitoring.

Cost-saving ideas include requesting multi-month supplies when appropriate, aligning refill reminders with seasonal triggers, and using one preferred device to reduce training errors. Clinicians may adjust to the lowest effective strength to maintain control. Using a spacer with metered-dose inhalers can improve delivery and technique consistency when recommended.

Questions to Ask Your Clinician

• Which strength is appropriate: 45/21, 115/21, or 230/21 mcg?
• Is a spacer or valved holding chamber recommended with this MDI?
• What is the plan for quick relief and action steps for flares?
• How long should this strength be tried before reassessment?
• Would a dry powder device be suitable compared with the HFA aerosol?
• How should inhaler technique be checked and retrained over time?
• Are there medicines or supplements that may interact with salmeterol or fluticasone?

Authoritative Sources

• GSK Prescribing Information
• FDA DailyMed
• Health Canada DPD

Start your Advair HFA Inhaler order for prompt US delivery from Canada.