Wellbutrin® XL Tablets for Major Depressive Disorder

This XL form of bupropion is an antidepressant for major depressive disorder and seasonal affective disorder. This page shows strengths, safety basics, and how to place an order, with Ships from Canada to US options. If you pay cash, compare Bupropion XL without insurance to understand potential out-of-pocket differences.

What Wellbutrin Is and How It Works

Wellbutrin XL® is the brand name for bupropion hydrochloride extended-release tablets. The treatment belongs to the norepinephrine and dopamine reuptake inhibitor class. It may help improve mood and reduce depressive symptoms by modulating these neurotransmitters. This medicine is not an SSRI.

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The XL formulation releases the medicine over 24 hours for once-daily dosing. Swallow tablets whole to maintain controlled release. Use follows labeled indications for major depressive disorder and prevention of seasonal episodes in seasonal affective disorder. Your clinician will confirm suitability based on your history and other medicines.

Who It’s For

This therapy is indicated for adults diagnosed with Major Depressive Disorder. It is also used to prevent seasonal major depressive episodes linked to Seasonal Affective Disorder. Generic Wellbutrin XL provides the same active ingredient as the reference brand when prescribed. People with a seizure disorder should not use this medicine. It is also contraindicated in those with a history of bulimia or anorexia nervosa. Do not use during or within 14 days of MAOI treatment. Avoid starting if you recently stopped alcohol, benzodiazepines, barbiturates, or antiepileptics abruptly.

Dosage and Usage

For major depressive disorder, a typical starting dose is Bupropion XL 150 mg once each morning. Your prescriber may increase the dose after several days if tolerated. For seasonal affective disorder, treatment often begins in the early fall and continues through the winter. Take tablets in the morning to limit sleep disturbance. Swallow whole; do not cut, crush, or chew. Do not take more than prescribed. If you see an inert tablet shell in stool, that can be expected with extended-release products. Your clinician may adjust timing with other therapies in the Antidepressant class.

Strengths and Forms

This medicine is supplied as once-daily, extended-release tablets. Common strengths include:

• Bupropion XL 300 mg
• 150 mg extended-release tablet

Not all strengths or pack sizes are always available. Availability can vary by dispensing pharmacy and manufacturer.

Missed Dose and Timing

If you miss a dose, skip it and take the next dose the following day. Do not double up to make up for a missed tablet. Keep doses in the morning when possible to reduce insomnia. Maintain a consistent daily schedule. If you miss several doses, contact your prescriber for guidance. Restarting after multiple days may require clinical advice to reduce seizure risk.

Storage and Travel Basics

Store tablets at room temperature in a tightly closed container. Keep the bottle dry and away from excess heat and moisture. Store out of reach of children and pets. When you travel, carry your medicine in original labeled packaging. Pack it in your carry-on and bring a copy of your prescription. Keep your daily schedule consistent across time zones when possible. Do not place tablets in a pill organizer that exposes them to humidity for extended periods.

Benefits

This medicine offers once-daily dosing, which can support adherence. The extended-release design provides steady exposure over the day. It is indicated to treat major depressive disorder and to prevent depressive episodes tied to seasonal patterns. Bupropion XL fits into many treatment plans when an activating option is appropriate. Your prescriber may consider it alone or with other therapies based on symptoms and history.

Side Effects and Safety

• Insomnia or restlessness: often improves with morning dosing
• Dry mouth: sip water or use sugar-free lozenges
• Nausea or stomach upset: usually mild and transient
• Headache: monitor and report persistent symptoms
• Dizziness: use care with driving until you know effects
• Tremor or sweating: report if persistent
• Constipation: increase fluids and fiber as advised
• Fast heartbeat: seek care if severe or ongoing

Serious risks include seizures, especially at higher doses or with predisposing factors. Other rare but important risks include increases in blood pressure, severe allergic reactions, angle-closure glaucoma in susceptible individuals, and mood changes such as agitation, mania, or suicidal thoughts. Contact a clinician promptly if severe mood or behavior changes occur, particularly after initiation or changes in dose.

Drug Interactions and Cautions

Do not use with MAOIs or within 14 days of stopping an MAOI. Avoid taking other bupropion-containing products at the same time. Alcohol can increase neuropsychiatric effects; abrupt alcohol cessation also increases seizure risk. Bupropion is a CYP2D6 inhibitor and may raise levels of some antidepressants, antipsychotics, beta blockers, and tamoxifen. Strong CYP2B6 inducers or inhibitors can affect bupropion or its metabolites. Use caution with medicines that lower the seizure threshold, such as some antipsychotics and systemic steroids. For context on antipsychotic therapy, see Abilify Uses and Abilify Side Effects. Linezolid or IV methylene blue may cause serious reactions; consult the label and your prescriber before combining.

What to Expect Over Time

Symptom improvement varies. Some people notice changes in energy or concentration before mood changes. Steady, consistent dosing helps the treatment work as intended. Keep your follow-up appointments so your prescriber can assess benefit and tolerability. Do not stop suddenly without medical direction. If treatment continues into spring for seasonal affective disorder, your clinician may decide when to taper.

Compare With Alternatives

Bupropion SR contains the same active ingredient in a sustained-release form taken more than once daily. It is used for depression and, in some cases, for smoking cessation when prescribed as a different brand formulation. Release profile and dosing differ from the XL option.

Duloxetine is an SNRI used for depression, anxiety disorders, and certain pain conditions. It acts on serotonin and norepinephrine and is taken once or twice daily depending on the product. Your prescriber will consider symptoms, coexisting conditions, and prior response when discussing alternatives.

Pricing and Access

We list transparent options so you can review the Bupropion XL price before checkout. Cash-pay totals vary by strength, manufacturer, and quantity. If you comparison shop, you can also evaluate Bupropion XL cost against other generics in the class. We provide encrypted checkout and prescription verification to support a smooth process. Orders are dispensed by licensed Canadian pharmacies and Ships from Canada to US. Looking for offers? See current Promotions for periodic updates.

Availability and Substitutions

Supply can vary by strength and manufacturer. If a requested strength is temporarily unavailable, your prescriber may recommend a clinically appropriate alternative or a different release form. Substitutions should match the active ingredient and release characteristics your clinician has prescribed. We do not guarantee specific manufacturers.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with major depressive disorder or those needing prevention of seasonal depressive episodes, without risk factors that increase seizures. It is not suitable for people with a seizure disorder or those with bulimia or anorexia nervosa. Discuss liver or kidney concerns, bipolar spectrum history, glaucoma risk, and blood pressure control with your prescriber.

To help manage costs, consider multi-month supplies if appropriate for you. Use refill reminders so you do not miss doses. Keep tablets in their original container, and plan ahead if you travel so you have enough medication. You can also read background information on broader mood conditions in our Depression pages.

Questions to Ask Your Clinician

• Is this therapy appropriate for my diagnosis and history?
• How should I time my dose with other medicines I take?
• What signs suggest I should contact you promptly?
• Which potential interactions matter most with my current regimen?
• How long should I continue before reassessing benefit?
• What is the plan if I have bothersome insomnia or anxiety?
• Could an alternative release form or medicine fit me better?

Authoritative Sources

Order when ready for prompt, express, temperature-controlled handling when required, and Ships from Canada to US. This page is informational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the official labeling.