Please note: a valid prescription is required for all prescription medication.
What Dapagliflozin Is and How It Works
Dapagliflozin is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor. This class lowers blood glucose by blocking glucose reabsorption in the kidneys. More glucose is excreted in the urine, which can also reduce body weight and blood pressure. It is supplied as tablets in 5 mg and 10 mg strengths. Common uses include type 2 diabetes, chronic kidney disease, and heart failure risk reduction. Many people search for dapagliflozin tablets and the dapagliflozin 10 mg tablet for these approved uses. CanadianInsulin is a prescription referral service. Prescriptions are verified with your clinic, and orders are filled by licensed Canadian pharmacies.
For type 2 diabetes, dapagliflozin helps lower A1C as add‑on therapy to diet and exercise. It may be used alone or with metformin, insulin, or other agents. For heart failure, it reduces the risk of hospitalization, including in patients without diabetes. For chronic kidney disease, it slows decline in kidney function and lowers the risk of kidney failure and cardiovascular death. Patients and clinicians may consider the 10 mg strength for heart failure and CKD indications, while 5 mg is a typical starting dose for glycemic control.
Learn more about related conditions in Type 2 Diabetes, Heart Failure, and Kidney Disease categories.
Dosage and Usage
- Typical starting dose for type 2 diabetes: 5 mg once daily in the morning. May increase to 10 mg once daily if tolerated and additional control is needed.
- Heart failure or chronic kidney disease indications: 10 mg once daily is commonly used.
- Take with or without food. Morning dosing may reduce nocturia for some patients.
- Assess kidney function before starting and during therapy. Do not use in patients on dialysis.
- Volume status matters. Consider correcting dehydration before starting to reduce hypotension risk.
- Missed dose: take when remembered the same day. Skip if close to the next dose. Do not double doses.
- Before surgery or prolonged fasting, clinicians may hold dapagliflozin for 3 days to lower ketoacidosis risk.
- Storage: keep tablets at 20–25°C (68–77°F). Excursions 15–30°C (59–86°F) are allowed.
- Protect from moisture. Store in the original container with the desiccant if present.
- Keep out of reach of children and pets.
- Travel: carry in original labeled packaging. Keep in carry‑on luggage and avoid extreme heat (do not leave in a hot car).
- Do not use tablets past the labeled expiration date.
Benefits and Savings
Dapagliflozin helps reduce A1C by about 0.5–1.0% when added to baseline therapy. Many patients see modest weight loss, often 2–3 kg over time. Systolic blood pressure reductions of 3–5 mmHg are common. In heart failure, it lowers the risk of hospitalization and can improve symptoms. In CKD, it slows eGFR decline and reduces progression to kidney failure.
Convenience is another benefit. A once‑daily tablet suits many routines and combines well with metformin, insulin, GLP‑1 receptor agonists, or DPP‑4 inhibitors. For those comparing the dapagliflozin 10 mg price to branded options, generic availability often reduces out‑of‑pocket cost. Many customers save 60–80% vs typical U.S. prices.
See our promotions page for current offers, including any dapagliflozin coupon if available.
Side Effects and Safety
- Genital yeast infections (more common in females and uncircumcised males)
- Urinary tract infections and increased urination
- Thirst, dry mouth, or dehydration
- Dizziness or low blood pressure, especially in volume depletion
- Nausea or abdominal discomfort
- Back pain, nasopharyngitis, or headache
- Increases in LDL cholesterol may occur
Serious risks are uncommon but include ketoacidosis (even with normal glucose), severe urinary infections, Fournier’s gangrene, acute kidney injury in susceptible patients, and severe allergic reactions. Hypoglycemia risk increases when used with insulin or sulfonylureas; clinicians may lower background doses to reduce this risk. Use caution in patients with frequent UTIs, volume depletion, or history of genital mycotic infections. Avoid use in pregnancy, especially in the second and third trimesters, and do not use in patients on dialysis.
Onset Time
Blood glucose effects begin within the first 1–2 weeks, with A1C changes accumulating over 12–24 weeks as dosing stabilizes. Weight changes usually emerge over 4–12 weeks and can continue gradually with ongoing therapy. In heart failure, benefits on symptoms and reduced hospitalization risk can appear within weeks. Kidney outcomes are tracked over months to years, with early stabilization in eGFR slope often seen after initiation.
Compare With Alternatives
Dapagliflozin is the generic of Farxiga®. Patients who need brand labeling can consider the branded option; see Farxiga Dapagliflozin for details. The active ingredient is the same.
Other SGLT2 inhibitors include empagliflozin (Jardiance®) and canagliflozin (Invokana®). All reduce blood glucose and provide cardiovascular and kidney benefits, though trial populations and labeling differ. Choice often depends on comorbidities, eGFR thresholds, and tolerability.
Another path is a GLP‑1 receptor agonist such as Trulicity® or oral semaglutide (Rybelsus®). These agents lower A1C and support weight loss, and they combine well with SGLT2 inhibitors when appropriate. For glycemic management, some patients use dapagliflozin with a GLP‑1 RA to target both fasting and post‑meal glucose.
Combination Therapy
- With metformin for foundational type 2 diabetes management.
- With insulin or sulfonylureas; consider reducing background doses to limit hypoglycemia.
- With GLP‑1 receptor agonists for additional A1C and weight benefits.
- With ACE inhibitors or ARBs in CKD for kidney protection.
- Use caution with loop or thiazide diuretics due to volume depletion risk; monitor blood pressure and renal function.
Patient Suitability and Cost‑Saving Tips
Candidates include adults with type 2 diabetes needing additional glycemic control, patients with symptomatic heart failure (reduced or preserved ejection fraction) to reduce hospitalization risk, and patients with chronic kidney disease to slow progression. It is not for type 1 diabetes due to ketoacidosis risk. It should not be used in dialysis. Those with active genital infections, recurrent UTIs, severe dehydration, or hypersensitivity to dapagliflozin may not be suitable. Use caution in older adults and in those on diuretics or with low blood pressure.
Cost‑saving tips include choosing generic dapagliflozin when appropriate, considering a multi‑month supply, and aligning refills to reduce shipping frequency. Comparing the dapagliflozin price by strength and quantity can help match budget needs. CanadianInsulin works with licensed and vetted partner pharmacies to provide authentic medications, a broad selection, and value‑focused pricing with prompt, express, cold‑chain shipping.
Authoritative Sources
AstraZeneca Farxiga Prescribing Information
Health Canada Product Monograph: Forxiga (dapagliflozin)
FDA Label: Dapagliflozin Tablets
Order Dapagliflozin from CanadianInsulin: add to cart, upload your prescription, and we ship with prompt, express, cold‑chain handling.
This page is for educational purposes and does not replace professional medical advice. Always consult a qualified healthcare provider about diagnosis, treatment, and medication choices.
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What is dapagliflozin used for?
Dapagliflozin is used for adults with type 2 diabetes to improve blood glucose, and to reduce the risk of hospitalization for heart failure. It is also used in chronic kidney disease to slow decline in kidney function and reduce cardiovascular risk. It is not indicated for type 1 diabetes or for patients on dialysis.
How does dapagliflozin work and what class is it?
Dapagliflozin is an SGLT2 inhibitor. It blocks glucose reabsorption in the kidneys, increasing urinary glucose excretion. This lowers blood sugar and can reduce body weight and blood pressure. The mechanism also supports cardiovascular and kidney benefits observed in clinical trials for heart failure and chronic kidney disease.
When will dapagliflozin start working?
Blood glucose effects begin within 1–2 weeks, with fuller A1C reduction by 12–24 weeks. Some heart failure benefits, such as fewer hospitalizations, are seen within weeks of starting. Weight changes usually appear over 4–12 weeks. Clinicians will monitor labs and symptoms to assess response over time.
What are common dapagliflozin side effects?
Common effects include genital yeast infections, urinary tract infections, increased urination, thirst, and dizziness from low blood pressure. Nasopharyngitis, back pain, and mild GI symptoms can occur. Serious but rare risks include ketoacidosis, severe urinary infections, Fournier’s gangrene, and kidney injury. Hypoglycemia risk rises with insulin or sulfonylureas.
Does dapagliflozin cause weight loss?
Modest weight loss is common due to increased urinary glucose loss. Many adults lose about 2–3 kg over several months, though results vary. Combining dapagliflozin with diet, activity, and other medicines can influence outcomes. A clinician will individualize therapy to balance glucose control, cardiovascular, and kidney goals.
What is the brand name of dapagliflozin?
The brand name is Farxiga. The generic product contains the same active ingredient, dapagliflozin. Many patients use the generic to reduce cost while maintaining the intended therapeutic effect. CanadianInsulin offers both options, subject to prescription verification and pharmacy dispensing standards.
How much does dapagliflozin cost?
Pricing varies by strength (5 mg vs 10 mg) and quantity. Generic dapagliflozin often costs less than brand. At CanadianInsulin, many customers save compared to typical U.S. pricing. Check the product page for current options and add to cart to see the best fit for your prescription.
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