Entresto

Entresto is a prescription medication used to treat heart failure. It contains a combination of sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker (ARB). This combination improves the heart’s ability to pump blood more effectively and reduces strain on the cardiovascular system, helping to lower the risk of hospitalization and death in patients with chronic heart failure.

Benefits:

• Enhances heart function by reducing strain and improving blood flow
• Lowers the risk of hospitalization due to heart failure exacerbations
• Reduces the risk of death in patients with chronic heart failure
• Improves quality of life for individuals with reduced ejection fraction (HFrEF)

Dosage:

• The initial dose is typically 49 mg/51 mg taken twice daily
• For patients new to ARBs or ACE inhibitors, a lower starting dose of 24 mg/26 mg twice daily may be recommended
• The maintenance dose is usually 97 mg/103 mg taken twice daily after titration
• Doses should be adjusted based on medical advice and patient response

Usage Instructions:

• Take Entresto exactly as prescribed by your healthcare provider
• Swallow the tablet whole with or without food
• Maintain a consistent schedule by taking doses at the same time every day
• Avoid stopping the medication suddenly without consulting your doctor
• If you miss a dose, take it as soon as you remember. Skip it if your next dose is near. Do not double the dose

Storage Information:

• Store at room temperature, between 68°F to 77°F (20°C to 25°C)
• Keep the medication in its original container, away from moisture and heat
• Do not store in a bathroom or humid environment

Warnings and Precautions:

• Do not use Entresto if you are pregnant, as it can harm an unborn baby
• Avoid use if you have a history of angioedema related to ACE inhibitors or ARBs
• Monitor blood pressure regularly to avoid hypotension
• Inform your healthcare provider of all medications you are taking to prevent drug interactions
• Avoid potassium supplements or salt substitutes containing potassium unless directed by a doctor
• Use caution if you have kidney or liver impairment

Common Side Effects:

• Low blood pressure (hypotension), which may cause dizziness or fainting
• Increased blood potassium levels (hyperkalemia)
• Kidney function changes or failure in rare cases
• Cough or cold-like symptoms
• Fatigue, headache, or nausea

More information about Entresto:

• Product Monograph – Health Canada
• U.S. Food and Drug Administration Medication Guide