Entresto® Tablets for Heart Failure

Entresto® is a prescription tablet that combines sacubitril and valsartan to treat certain types of chronic heart failure. From Canada, CanadianInsulin ships to the US so patients can review Canadian pricing and buy Entresto online with US delivery from Canada, including when ordering without insurance. You can order Entresto tablets with a valid prescription for prompt US shipping.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

What Entresto® Is and How It Works

Entresto is a fixed-dose combination of sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin receptor blocker (ARB). Together, these medicines help relax blood vessels, reduce sodium and fluid retention, and decrease strain on the heart. Entresto is approved to reduce the risk of cardiovascular death and hospitalization in certain patients with chronic heart failure with reduced ejection fraction.

This ARNi (angiotensin receptor neprilysin inhibitor) approach supports the heart by enhancing protective peptides while blocking harmful effects of angiotensin II. For a deeper overview of mechanism and class, see Entresto Drug Class.

Patients often compare the Entresto price online and sacubitril/valsartan price online when exploring treatment options. If looking to buy sacubitril/valsartan 24/26 mg or higher strengths, this page explains labeled strengths and usage to support informed discussions with a clinician.

Who Entresto® Is For

Entresto is indicated for adults with chronic heart failure and reduced ejection fraction to lower the risk of cardiovascular death and heart failure hospitalization. It may also be used in certain pediatric patients as directed by a clinician.

Do not use Entresto with an ACE inhibitor or within 36 hours of the last ACE inhibitor dose. It is also contraindicated in patients with a history of angioedema related to ACE inhibitors or ARBs, and in patients with diabetes treated with aliskiren. Entresto should not be used during pregnancy. People with severe liver impairment, advanced kidney problems, or very low blood pressure require careful evaluation before therapy.

For broader treatment information by condition, browse our Heart Failure category.

Dosage and Usage

Entresto is taken by mouth twice daily. Tablets may be taken with or without food and swallowed whole. The starting dose is based on current or prior heart failure therapy, kidney and liver function, and blood pressure. Many adults who were previously on a moderate or high dose of an ACE inhibitor or ARB may start at 49/51 mg twice daily and titrate to the target 97/103 mg twice daily as tolerated. Those who are not currently on an ACE inhibitor or ARB, or who have certain kidney or liver considerations, often start at 24/26 mg twice daily with careful titration.

There must be a 36-hour washout period after stopping an ACE inhibitor before starting Entresto. Dose adjustments are guided by blood pressure, kidney function, and potassium levels. Always follow the prescriber’s directions and the official label for changes during therapy. For more on labeled schedules and titration, review Entresto Dose Recommendations.

Strengths and Forms

Entresto is available as film-coated tablets in the following strengths:

• 24/26 mg
• 49/51 mg
• 97/103 mg

Availability can vary. Patients often search for Entresto 24/26 mg buy options, Entresto 49/51 mg tablets online, or Entresto 97/103 mg buy online to match the dose recommended by their clinician.

Missed Dose and Timing

If a dose is missed, take the next dose at the regular scheduled time. Do not take two doses at the same time to make up for a missed dose. Entresto is designed for twice-daily administration, so consistent timing helps maintain steady therapeutic effect.

Storage and Travel Basics

Store tablets at room temperature, typically 20 to 25°C (68 to 77°F). Keep the bottle tightly closed and protected from moisture. Do not store tablets in a bathroom or near heat sources. For travel, keep medicine in original labeled packaging, carry it in your hand luggage, and bring a copy of your prescription. If travel plans include hot climates, use an insulated pouch to protect tablets from excessive heat.

Benefits

When used as directed, Entresto helps reduce the risk of cardiovascular death and hospitalization in chronic heart failure with reduced ejection fraction. Many patients also experience improved exercise tolerance and fewer fluid-related symptoms over time. Twice-daily tablets can be coordinated with morning and evening routines, and the titration approach allows clinicians to match the dose to patient tolerability.

Side Effects and Safety

• Low blood pressure (dizziness, lightheadedness)
• Increased potassium
• Cough
• Kidney function changes
• Fatigue or headache
• Stomach discomfort or nausea

Serious reactions can occur, including angioedema, which may present as swelling of the face, lips, tongue, or throat. Seek emergency care if swelling or breathing difficulty occurs. Fetal toxicity can occur if taken during pregnancy. Kidney problems and significant elevations in potassium are also possible, especially with other agents affecting the renin-angiotensin-aldosterone system or potassium balance. For a deeper review of common effects and practical tips, read Entresto Side Effects.

Drug Interactions and Cautions

• ACE inhibitors: contraindicated; allow a 36-hour washout before starting Entresto
• Aliskiren: avoid in patients with diabetes; use caution in others
• Potassium-sparing diuretics and potassium supplements: risk of hyperkalemia
• NSAIDs: may reduce kidney function, particularly in volume-depleted patients
• Diuretics and other antihypertensives: additive blood pressure lowering
• Lithium: risk of increased lithium levels and toxicity

People with a history of angioedema on ACE inhibitors or ARBs should not use Entresto. Use caution in hepatic or renal impairment and in patients with low baseline blood pressure. Alcohol and dehydration can increase the risk of hypotension.

What to Expect Over Time

Blood pressure often decreases early in therapy. Symptom improvements may follow over weeks to months as the dose is optimized. Clinicians typically check kidney function and potassium during initiation and after dose changes. Staying consistent with twice-daily dosing helps maintain benefits. Entresto is a long-term therapy for many patients, and reassessment occurs at regular follow-up visits.

Compare With Alternatives

Other prescription options for heart failure management include ACE inhibitors and ARBs, as well as mineralocorticoid receptor antagonists and loop diuretics. Some patients transition from an ACE inhibitor or ARB to an ARNi for guideline-directed therapy. Two commonly used alternatives that address different parts of heart failure care are Valsartan and Spironolactone. Clinicians also use diuretics such as furosemide when fluid control is needed. Product choice depends on the clinical picture, tolerability, and guideline recommendations.

Pricing and Access

CanadianInsulin lists Entresto from Canada with Canadian pricing and ships to US addresses. Patients compare the Entresto cost from Canada to typical US retail pricing when paying a cash price. Many prefer to order Entresto tablets online and have the medicine delivered from Canada. To understand total costs, insurance coverage, and common questions about cash-pay orders, see our editorial Entresto Price Guide.

To check the Entresto price online for 24/26 mg, 49/51 mg, or 97/103 mg, use the product page to view current options and Canadian pricing. Patients who pay out of pocket for Entresto often compare the sacubitril/valsartan price online before placing an order. If looking for extra savings opportunities, visit our Promotions page. Checkout is protected with encrypted processing.

Availability and Substitutions

Stock may vary by strength. If a preferred strength is temporarily unavailable, a prescriber may recommend an appropriate alternative or an interim supply strategy. Do not change medicines or doses without a clinician’s guidance.

Patient Suitability and Cost Saving Tips

Entresto may be suitable for adults with heart failure with reduced ejection fraction who are appropriate candidates for ARNi therapy. It is not suitable during pregnancy and is not recommended for patients with a history of angioedema related to ACE inhibitors or ARBs. Careful evaluation is needed when there is severe kidney or liver disease or low baseline blood pressure.

• Discuss a 90-day supply to reduce per-tablet cost and simplify refills.
• Ask about home blood pressure monitoring to support safe titration.
• Set refill reminders to avoid treatment gaps.
• Keep an updated medication list to help clinicians check for interactions.
• If switching from an ACE inhibitor, plan the 36-hour washout in advance.

Questions to Ask Your Clinician

• Is Entresto appropriate for this type of heart failure and ejection fraction?
• Which starting dose is suitable, and when should labs be checked?
• How should side effects like dizziness or cough be managed?
• What signs of angioedema require immediate medical attention?
• Which other medicines should be continued or adjusted with Entresto?
• Are there diet or potassium restrictions to consider?
• How long should therapy continue once the target dose is reached?

Authoritative Sources

• FDA Prescribing Information
• Novartis Entresto Product Page
• Health Canada Drug Product Database

What Entresto Is and How It Works

Ready to check Canadian pricing and place an order? You can buy Entresto online from Canada with US delivery from Canada through CanadianInsulin.