Uloric® (Febuxostat) Tablets for Gout

Febuxostat is a prescription urate-lowering medicine for gout. This page helps you compare options, dosing basics, safety, and access. We offer US delivery from Canada so you can order with Canadian pricing and prompt shipping. Savings may be available even without insurance.

What Uloric® Is and How It Works

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic. Uloric® is the brand name for febuxostat. It is a xanthine oxidase inhibitor. It lowers uric acid by blocking the enzyme that makes urate in the body. Lower uric acid reduces gout flares and helps shrink tophi over time.

Uloric® and generic febuxostat are for chronic management. They are not pain relievers for an acute gout attack. Your clinician may start therapy after a flare settles or continue it during a flare with separate flare treatment.

Who Uloric® Is For

Febuxostat is indicated to lower serum uric acid in adults with gout. In the US, it is generally used when allopurinol is not tolerated or did not work. It is not for asymptomatic hyperuricemia.

People who should avoid febuxostat include those taking azathioprine or mercaptopurine. Serious toxicity can occur with these drugs. Use caution if you have a history of major cardiovascular disease. Discuss risks and benefits carefully with your clinician.

Chronic kidney disease is common in gout. Febuxostat can be used in many patients with renal impairment. Your care team will guide testing and monitoring. For more gout resources, explore the Gout category. Kidney-related topics are covered within Kidney Disease.

Dosage and Usage

Follow your prescriber’s instructions. Typical US labeling begins at 40 mg by mouth once daily. Serum uric acid is rechecked after initiation.

• If uric acid remains above target, the dose may increase to 80 mg once daily.
• Do not exceed the maximum recommended 80 mg once daily in the US.
• Take with or without food. Swallow tablets whole with water.

Starting urate-lowering therapy can trigger gout flares. Clinicians often recommend flare prophylaxis when beginning febuxostat, such as with colchicine or an NSAID, typically for up to six months. Ask your clinician about the plan that fits your situation.

Strengths and Forms

Common presentations include:

• Tablets: 40 mg
• Tablets: 80 mg

Availability can vary by manufacturer and country. Your final fill may depend on stock at the dispensing pharmacy.

Missed Dose and Timing

If you miss a dose, take it when remembered the same day. If it is almost time for the next dose, skip the missed dose. Do not double up. Try to take febuxostat at the same time every day.

Storage and Travel Basics

Store tablets at room temperature in the original container. Keep the bottle tightly closed and dry. Protect from excess heat and moisture. When traveling, carry your medicine in hand luggage. Keep a copy of your prescription. US delivery from Canada helps you plan refills ahead of trips.

Benefits

• Reduces serum uric acid to reach a target set by your clinician.
• Helps prevent recurrent gout flares after urate is controlled.
• Supports gradual reduction of tophi with sustained control.
• Once-daily dosing for simplicity.

Side Effects and Safety

Common effects can include:

• Joint pain or a gout flare during initiation
• Nausea
• Rash
• Abnormal liver tests

Serious risks are uncommon but important. Febuxostat carries a boxed warning about higher risk of cardiovascular death compared with allopurinol in certain studies. Discuss your cardiovascular history with your clinician before starting. Severe hypersensitivity reactions can occur, including rash with systemic symptoms. Liver injury has been reported. Seek urgent care if you have chest pain, shortness of breath, severe rash, yellowing of the skin, or dark urine.

Drug Interactions and Cautions

• Do not use with azathioprine or mercaptopurine. Dangerous toxicity may occur.
• Tell your clinician if you take theophylline. Extra monitoring may be advised.
• Antacids containing magnesium or aluminum may lower absorption. Separate doses by at least two hours.
• Warfarin can be used with febuxostat, but monitoring is still important.
• Limit alcohol, which can raise uric acid and trigger flares.

Tell your care team about all medicines, vitamins, and supplements you take. Share your history of heart disease, stroke, liver disease, or kidney problems.

What to Expect Over Time

Uric acid often falls within days. Flares may increase early as urate shifts. This does not mean the medicine is not working. As urate reaches target and remains controlled, flares usually decrease. Tophi may shrink gradually with sustained low urate. Your clinician will check uric acid and liver tests at intervals. Many patients review goals every few months, then less often when stable.

Compare With Alternatives

Several therapies lower uric acid. The most commonly used alternative is Allopurinol, another xanthine oxidase inhibitor. It is often first-line and is available in multiple strengths. Other options include probenecid for patients who can use uricosurics, and pegloticase for select severe, refractory cases managed by specialists. Choice depends on your history, kidney function, prior response, and tolerability.

Pricing and Access

Take advantage of Canadian pricing with US shipping. You can compare febuxostat cost and check availability before you place an order. Many people buy febuxostat online to manage ongoing therapy costs. If you pay cash, you can still see your options and potential savings.

• Review current febuxostat price and choose your tablet strength.
• Complete checkout with secure, encrypted payment.
• We coordinate prescription verification with your clinic.

US delivery from Canada helps you access consistent supply and pricing. You can order Uloric brand or generic febuxostat depending on availability.

Availability and Substitutions

Stock can vary by strength and manufacturer. If febuxostat is unavailable, your prescriber may recommend an alternative. You can also browse related options within our Gout collection to understand therapy choices guided by your clinician.

Patient Suitability and Cost Saving Tips

• Good candidates include adults with gout needing urate-lowering therapy who cannot use or did not respond to allopurinol.
• Not suitable if you take azathioprine or mercaptopurine, or if your clinician advises against it due to cardiovascular risk.
• Ask about multi-month supplies if stable on therapy to reduce per-fill costs.
• Set refill reminders so you do not miss doses.
• Combine lifestyle measures with medication to reduce flares over time.

If you also manage diabetes, you may find this overview helpful: Gout And Diabetes. It explains how these conditions can overlap and affect care plans.

Questions to Ask Your Clinician

• Is febuxostat appropriate for me given my heart history?
• What uric acid target should I aim for?
• How long should I use flare prophylaxis when starting?
• When will we recheck blood tests and liver enzymes?
• What signs mean I should call the clinic or seek urgent care?
• Are there food or alcohol limits I should follow?
• What are my options if this does not reach urate goals?

Authoritative Sources

• Uloric Prescribing Information (DailyMed)
• Health Canada Product Monograph: Febuxostat
• FDA Safety Communication: Febuxostat

Ready to get started? Place your febuxostat request with US delivery from Canada today. This information is educational and does not replace your clinician’s advice.