Avapro® Tablets for Hypertension

Irbesartan is an angiotensin II receptor blocker used to lower blood pressure and help protect the kidneys in certain adults with type 2 diabetes. This page explains how it works, who it suits, and how to use it safely. Available with US delivery from Canada, you can also review options without insurance.

What Irbesartan Is and How It Works

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This medicine is the generic for Avapro®. It blocks the angiotensin II type 1 receptor, which helps relax blood vessels and reduce aldosterone effects. The result is lower vascular resistance and improved blood pressure control. Higher labeled doses, such as irbesartan 300 mg, may be used when clinically appropriate. In adults with type 2 diabetes and proteinuric kidney disease, the treatment can help slow progression when used as directed in guidelines.

Who It’s For

The therapy is indicated for adults with hypertension, including those requiring combination treatment. It is also used to treat diabetic nephropathy in adults with type 2 diabetes and hypertension with elevated urinary albumin. Explore related guidance under High Blood Pressure and Kidney Disease. For background on cardiorenal protection strategies, see Kerendia Uses.

Do not use if you are pregnant. Drugs that act on the renin-angiotensin system can harm an unborn baby. Avoid in people with known hypersensitivity to this class. Use caution if you are volume depleted, have bilateral renal artery stenosis, or are taking other agents that raise potassium. Concomitant aliskiren is not recommended in diabetes. Safety and effectiveness in pediatrics are not established.

Dosage and Usage

Follow your clinician’s directions and the official label. Typical adult starting dose is 150 mg once daily, taken with or without food. The dose may be titrated to 300 mg once daily based on response and tolerability. Some patients who are volume depleted may be started lower. People with diabetic nephropathy often require target doses for renoprotective benefit.

Swallow tablets whole with water. Try to take it at the same time each day. If you also take a diuretic, your prescriber may adjust the plan. When asked about titration steps, many adults are managed using irbesartan 300mg tablets if lower doses do not achieve goals. Keep consistent daily use unless your clinician advises a change.

Strengths and Forms

Film-coated tablets are available in several strengths. Labeled presentations include 75 mg, 150 mg, and 300 mg. Some products are formulated to United States Pharmacopeia specifications, including irbesartan tablets USP 300 mg. Fixed-dose combinations with hydrochlorothiazide exist as a separate prescription.

• Tablets: 75 mg, 150 mg, 300 mg
• Combination with HCTZ: commonly 150/12.5 mg, 300/12.5 mg, and 300/25 mg (brand equivalents include Avalide)
• Scored or unscored depends on manufacturer; do not split unless labeled

Availability can vary by manufacturer and package size.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. Skip the forgotten dose if it is close to your next scheduled dose. Do not double up. Keep a daily routine and set reminders to maintain steady exposure.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from excess heat and moisture. Keep them in the original, child-resistant container with the pharmacy label. When you travel, carry your medication in hand luggage with a copy of your prescription. Use a simple pill organizer if advised. Dispose of any damaged or out-of-date tablets per local guidance. Our checkout is encrypted to help protect your information.

Benefits

As an ARB, this therapy can help:

• Lower blood pressure: supports long-term cardiovascular risk reduction
• Kidney support: may slow nephropathy in adults with type 2 diabetes and albuminuria
• Once-daily dosing: simple schedule for many patients
• Combination friendly: can be used with diuretics and calcium channel blockers
• Tolerability profile: cough is less common than with ACE inhibitors

Side Effects and Safety

Common effects are generally mild and may include:

• Dizziness or lightheadedness
• Fatigue
• Headache
• Gastrointestinal upset
• Upper respiratory symptoms

More serious risks can occur. These can include symptomatic hypotension, changes in kidney function, and high potassium. Angioedema is rare but possible. Stop the medicine and seek urgent care if you develop swelling of the face, lips, tongue, or throat. Do not use during pregnancy; discuss contraception if applicable.

Drug Interactions and Cautions

Tell your healthcare professional about all medicines and supplements. Important interactions may occur with potassium-sparing diuretics, potassium supplements, and salt substitutes. NSAIDs can reduce antihypertensive effect and may impact kidney function. Lithium levels can increase. Dual blockade of the renin-angiotensin system is generally discouraged. ACE inhibitors, such as Benazepril, require careful clinical judgment when used in related regimens. Alcohol can enhance dizziness. Monitor labs as directed.

What to Expect Over Time

Blood pressure may start to improve after consistent daily use, with additional effect as the regimen stabilizes. Some adults reach targets on irbesartan tablet 300 mg, while others need combination therapy. Your clinician may adjust complementary medicines if needed. Keep home readings and share them at follow-up visits.

Compare With Alternatives

Other ARBs and combinations are available. Losartan is a well-known option; see Cozaar® for brand reference. For patients needing a diuretic component, telmisartan plus hydrochlorothiazide is another alternative; review Micardis® Plus. Some adults may be candidates for an irbesartan and hydrochlorothiazide product, such as Irbesartan HCTZ 300 12.5 mg, when monotherapy does not achieve goals. Choice depends on comorbidities, lab profile, and tolerability.

Pricing and Access

Canadian-sourced tablets are available with Ships from Canada to US fulfilment. Review formulary options, pack sizes, and generics to find a good fit. If you are comparing irbesartan 300 mg price, check the available manufacturers and quantities. See our Promotions page for current offers and neutral information on applying coupons when available.

Availability and Substitutions

Supply can vary by strength and pack size. If a particular lot is unavailable, a prescriber may recommend a therapeutically equivalent option or a diuretic combination. For example, irbesartan 300 25 mg in combination form may be suggested when appropriate. Final selection depends on your medical history and current lab values.

Patient Suitability and Cost-Saving Tips

This therapy suits many adults with hypertension, including those with type 2 diabetes and albuminuria. It may not be suitable if you are pregnant, planning pregnancy, or have specific renal artery conditions. People at risk for high potassium require monitoring. Ask about multi-month fills to reduce pharmacy visits, and consider a 90-day supply when appropriate. Set refill reminders so you do not miss doses. If a diuretic is needed, discuss whether Irbesartan hydrochlorothiazide 300 12.5 mg is clinically appropriate and cost-effective for your situation.

Questions to Ask Your Clinician

• Is this ARB the right first-line option for my blood pressure goals?
• How will we monitor kidney function and potassium over time?
• What signs of low blood pressure should prompt me to call?
• Could a diuretic combination improve control if monotherapy is not enough?
• Are there medicines or supplements I should stop when starting this therapy?
• How often should I check my blood pressure at home?

Authoritative Sources

• DailyMed: Irbesartan Tablets Prescribing Information
• FDA: Avapro (irbesartan) Label
• Health Canada DPD: Irbesartan

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