Persantine® (Dipyridamole) Tablets for Antiplatelet Therapy

What Persantine® Is and How It Works

Persantine is the brand name for dipyridamole, an antiplatelet medicine used to help reduce thromboembolic complications after cardiac valve replacement when prescribed as an adjunct to warfarin. It is supplied as oral tablets. CanadianInsulin is a prescription referral service. Prescriptions are verified with your clinic, and orders are filled by licensed Canadian pharmacies. Many visitors look for Persantine price information and also search for Persantine without insurance to plan out-of-pocket spending.

Dipyridamole helps keep platelets from sticking together. It increases local adenosine levels and inhibits phosphodiesterase, which raises platelet cyclic AMP. These actions reduce platelet aggregation and thrombus formation. Persantine does not thin blood in the same way as warfarin and does not act as a pain reliever. It is often used together with other antithrombotic therapies under a prescriber’s guidance.

We work with licensed and vetted partner pharmacies that dispense authentic brand medications, offer a broad selection, and support value-focused pricing. For a broader overview, see What Is Persantine Uses Benefits And Side Effects.

Dosage and Usage

• Typical adult dose: 75–100 mg four times daily (total 300–400 mg/day) as an adjunct to warfarin for patients with prosthetic cardiac valves, as directed by the prescriber.
• Swallow tablets whole with water. Taking doses with meals may help reduce stomach upset.
• Titration is not usually required. Dosing may be adjusted based on tolerance and clinical goals set by the prescriber.
• Missed dose: If a dose is missed, take it when remembered unless it is close to the next dose. Do not double up.
• Do not use Persantine tablets for cardiac stress testing. Intravenous dipyridamole is used for pharmacologic stress testing in supervised settings, not the oral tablets.
• Use with other antithrombotics (e.g., warfarin, aspirin) follows physician guidance. Monitor for additive effects such as bleeding or bruising.

• Store tablets at 20–25°C (68–77°F). Short excursions 15–30°C (59–86°F) are generally acceptable.
• Keep in the original, tightly closed container. Protect from excessive heat, moisture, and light.
• For travel, pack in your carry-on with a copy of your prescription. Keep a backup supply if possible.
• Do not store in a bathroom or glove compartment. Avoid freezing or extreme temperatures.
• Use a pill organizer only if it stays dry and at room temperature. Retain the labeled bottle for reference.

Benefits and Savings

Persantine supports antiplatelet effects that help reduce thromboembolic complications when used with warfarin in patients with prosthetic heart valves. Tablets offer consistent daily dosing. The mechanism is complementary to anticoagulants, giving clinicians options to tailor therapy for individual needs.

Many customers save 60–80% vs typical U.S. prices. Even without insurance, ordering through CanadianInsulin can reduce out-of-pocket costs compared with many U.S. retail options. If planning a multi-month fill, higher-quantity packs may stretch budgets and reduce shipping frequency.

See our promotions page for current offers, including any Persantine coupon if available.

Side Effects and Safety

• Headache
• Dizziness or lightheadedness
• Flushing or warmth
• Gastrointestinal upset (nausea, stomach pain, diarrhea)
• Rash or itching
• Fatigue

Less common but more serious effects may include low blood pressure, fast heartbeat, chest pain, or worsening angina in patients with coronary artery disease. Rare allergic reactions can occur. Use with caution in conditions where vasodilation is risky, such as severe coronary disease or unstable angina. When combined with anticoagulants or other antiplatelets, watch for bleeding or easy bruising. Patients with liver impairment, severe hypotension, or recent myocardial infarction require individualized evaluation.

Onset Time

Platelet inhibition occurs within hours of a dose, with peak effects typically seen in about 1–3 hours. Consistent dosing maintains antiplatelet activity. Clinical benefits in reducing thromboembolic risk rely on ongoing, regular use as directed by the prescriber, alongside background therapies such as warfarin where indicated. Headache and flushing, when they occur, are often most noticeable early and may lessen with continued therapy.

Compare With Alternatives

Aggrenox® (aspirin/extended-release dipyridamole) is indicated to reduce the risk of stroke in patients with a history of transient ischemic attack or completed ischemic stroke. It combines aspirin with extended-release dipyridamole in a twice-daily capsule, which differs from Persantine tablets in both formulation and indication.

Plavix® (clopidogrel) is an oral antiplatelet used in coronary, cerebrovascular, and peripheral arterial disease settings. It inhibits platelet activation via the P2Y12 pathway, not via phosphodiesterase inhibition. Choice among agents depends on clinical indication, concomitant therapies, bleeding risk, and prescriber judgment.

Generic dipyridamole tablets provide the same active ingredient as Persantine in immediate-release form. Product selection (brand vs generic, or alternative antiplatelets) should follow the prescriber’s plan and each patient’s clinical profile.

Combination Therapy

• Warfarin plus Persantine: Common pairing after prosthetic valve placement per prescriber. Monitor INR for warfarin and clinical signs of bleeding.
• Aspirin plus Persantine: Some patients may use both agents; bleeding risk increases with dual therapy.
• Triple therapy (warfarin + aspirin + Persantine): May be considered in select cases under specialist care; bleeding risk rises, and careful monitoring is needed.
• Adenosine or adenosine-acting agents: Dipyridamole may enhance adenosine effects; clinicians account for this in dosing and monitoring.
• Antihypertensives and vasodilators: Additive blood pressure effects can occur; clinical supervision guides adjustments.

Patient Suitability and Cost-Saving Tips

Persantine may be considered for patients who need adjunctive antiplatelet therapy with warfarin after cardiac valve replacement, when a clinician selects dipyridamole as part of the antithrombotic plan. It is not suitable for those with hypersensitivity to dipyridamole. Caution is warranted in patients with severe coronary artery disease, low blood pressure, recent myocardial infarction, or biliary obstruction. Pregnancy and breastfeeding decisions require clinician guidance.

Cost-saving strategies may include comparing brand and generic options when prescribed, choosing multi-month supplies to reduce per-shipment costs, and aligning refills for combined orders. Setting calendar reminders can help ensure timely reorders so therapy continues without gaps. Discuss the appropriate tablet strength and quantity with the prescribing clinic to avoid partial fills or waste.

Authoritative Sources

MedlinePlus: Dipyridamole Patient Information

DailyMed: Dipyridamole Prescribing Information (Search)

Order Persantine® from CanadianInsulin: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is for educational purposes and does not replace the advice of a licensed healthcare professional. Always follow the guidance of your prescribing clinician and the dispensing pharmacist.