Xultophy® Prefilled Pen for Type 2 Diabetes

The Xultophy® Prefilled Pen contains a fixed-ratio mix of basal insulin and a GLP-1 receptor agonist for adults with type 2 diabetes. It supports fasting and after-meal glucose control in one daily injection. You can explore access options with US delivery from Canada and see ways to save if paying cash.

This page explains how the medicine works, who may benefit, and how to use the pen safely. It also covers side effects, storage, and refill planning. If you are comparing coverage options, you can review Xultophy Prefilled Pen without insurance and learn practical steps to lower expenses.

What Xultophy Is and How It Works

Xultophy® pairs insulin degludec (a long-acting basal insulin) with liraglutide (a GLP-1 receptor agonist). The insulin provides steady background coverage. The GLP-1 component can enhance glucose-dependent insulin release, reduce glucagon, slow gastric emptying, and may reduce appetite.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

This combination is taken once daily, at about the same time, with or without food. Its dual approach targets both fasting and post-meal glucose. For broader context on the condition, see our overview of Type 2 Diabetes and browse related options under Insulin and GLP-1 Agonists.

Who It’s For

This treatment is for adults with type 2 diabetes when diet and exercise alone are not enough. It may be considered when basal insulin or a GLP-1 receptor agonist alone does not provide adequate control. It is not for type 1 diabetes or diabetic ketoacidosis.

People with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use it. Pancreatitis history, gallbladder disease, severe gastrointestinal disease, or severe renal impairment may require extra caution. Discuss your full history and medications with your clinician before starting an insulin degludec liraglutide prefilled pen.

Dosage and Usage

Use the pen once daily at roughly the same time each day. Inject subcutaneously in the abdomen, thigh, or upper arm, rotating sites to reduce skin reactions. Follow the pen’s step-by-step instructions for attaching a new needle, priming, dialing the dose, and delivering the injection.

The dose is individualized and titrated by your prescriber using label guidance, often informed by fasting blood glucose readings. Do not split a single daily dose into multiple injections. If your regimen includes other glucose-lowering medicines, your prescriber may adjust them to reduce hypoglycemia risk.

Check the pen label before each use to confirm the medicine and strength. Never share pens or needles, even with family members. If you have questions about technique, your healthcare team can demonstrate correct use and site rotation.

If you need a refresher on GLP-1 and insulin roles, our article on therapy classes may help: Diabetes Medications.

Strengths and Forms

The solution is supplied in disposable, prefilled, dial-a-dose pens containing 3 mL per pen. The fixed-ratio strength contains insulin degludec 100 units/mL with liraglutide 3.6 mg/mL. Pack sizes and pen counts may vary by supplier.

Many patients and prescribers reference the device by volume; if you do, the Xultophy 3 mL pen description above applies. Availability can differ by province and pharmacy partner, and inventory may change.

Missed Dose and Timing

If you miss a dose, take it when you remember on the same day. If it is nearly time for the next dose, skip the missed dose and resume your usual schedule. Do not take extra to make up a missed dose.

If several days are missed, review the official label and speak with your prescriber for guidance on restarting and titration. Monitor your glucose more often after any interruption in therapy or dose change.

Storage and Travel Basics

Keep unused pens refrigerated before first use. Do not freeze. Protect from direct heat and light. After first use, follow the label for in-use storage time and temperature range. Keep the pen cap on when not in use, and remove the needle after each injection.

When traveling, pack your supplies in a carry-on with pen needles, alcohol swabs, and snacks or glucose tablets. Use a protective case to reduce temperature swings and physical damage. Carry a copy of your prescription and a medication list. Some therapies may need temperature-controlled handling when required; check your travel plans ahead of time.

Keep all medicines out of reach of children and pets. Dispose of used needles in an FDA-cleared sharps container and follow local regulations for disposal.

Pen Handling and Sharps Disposal

Wash hands, attach a new needle, and prime the pen per the device guide. Select the prescribed dose, insert the needle into a lifted skin fold, and inject subcutaneously. Count slowly before removing the needle to ensure a full dose is delivered.

Do not reuse needles. Place used needles in a puncture-resistant sharps container. Do not throw loose needles into household trash. The Xultophy disposable pen is for single-patient use only; sharing may transmit infection.

Benefits

This medicine can simplify care by combining basal insulin with a GLP-1 agent in one daily pen. It may reduce the number of injections compared with taking the two components separately. The treatment supports fasting and post-meal glucose control while offering a familiar pen platform.

Using one device can also streamline training, supplies, and refill planning. Many patients appreciate having a single titration plan instead of managing two separate prescriptions.

Side Effects and Safety

• Gastrointestinal effects: nausea, vomiting, diarrhea, constipation
• Decreased appetite or weight changes
• Injection site redness, itching, or swelling
• Headache or dizziness
• Cold-like symptoms or cough
• Low blood sugar, especially with insulin or sulfonylureas

Serious but less common risks can include pancreatitis, gallbladder disease, acute kidney injury from dehydration, severe allergic reaction, and possible thyroid C-cell tumor risk associated with liraglutide. Seek emergency care for signs of anaphylaxis or severe abdominal pain. Hypoglycemia risk increases with concomitant insulin or sulfonylurea therapy; monitor glucose regularly and review recognition and treatment of low blood sugar with your care team.

Drug Interactions and Cautions

Using this combination with another GLP-1 receptor agonist is not recommended. Insulins and sulfonylureas may raise hypoglycemia risk when used together; your clinician may adjust therapy. Beta-blockers can mask signs of low blood sugar. Corticosteroids, certain antipsychotics, and some HIV medicines can affect glucose control.

The GLP-1 component may slow stomach emptying and affect absorption of oral medicines with a narrow therapeutic index. Alcohol can increase hypoglycemia risk and should be used cautiously. Always provide a full medication and supplement list to your prescriber and pharmacist.

What to Expect Over Time

Glucose readings may improve over weeks with consistent daily use and titration per the label. Gastrointestinal effects, if present, often lessen after the early phase. Keep a log of fasting readings, hypoglycemia symptoms, and injection sites.

Routine follow-up helps refine your dose and address technique questions. Balanced nutrition, regular activity, and adherence to your injection time can improve overall control.

Compare With Alternatives

Other combination and basal options may suit particular needs. For another fixed-ratio option that pairs basal insulin with a GLP-1 agent, consider Soliqua SoloStar Pens. If only a basal component is desired, Tresiba FlexTouch Pens may be discussed with your prescriber.

Choice depends on prior therapy, tolerance, goals, and device preferences. Your clinician can help select the most appropriate option.

Pricing and Access

Many shoppers look for ways to lower their prefilled pen cost. You can review Xultophy Prefilled Pen price, typical cash-pay approaches, and compare options. Some patients also ask about a prefilled pen coupon or discount; availability varies and may change over time.

We support transparent listings and US shipping from Canada with clear checkout. If you’re exploring a pen for sale, you can compare out of pocket cost and see current cash price before you order. For seasonal offers, visit our Promotions page.

Availability and Substitutions

If an item is unavailable, your prescriber may recommend an alternative in the same class or a different regimen. Pharmacy inventory can vary by partner. For questions on class-based options, you can also review resources on insulin and GLP-1 therapies.

If you and your clinician decide this class is appropriate, you may choose to Buy insulin degludec liraglutide pen through our platform once a valid prescription is on file.

Patient Suitability and Cost-Saving Tips

Suitable candidates often include adults currently on basal insulin who may benefit from adding a GLP-1 effect, or adults using a GLP-1 who need basal coverage. It is not suitable for type 1 diabetes, DKA, or for those with certain thyroid tumor risks.

To help reduce expenses, consider multi-month supplies when appropriate, use refill reminders, and align orders for supplies like pen needles. Review your plan’s coverage and any manufacturer support programs.

Questions to Ask Your Clinician

• Is this combination appropriate for my current A1C goals?
• How should I titrate the dose per the official label?
• What signs of low blood sugar should I watch for?
• How can I manage early gastrointestinal effects?
• What injection sites should I rotate through?
• Which of my other medicines may interact?
• What should I do if I miss several days?

Authoritative Sources

For full prescribing details and safety information, review the official U.S. label on DailyMed: DailyMed provides current FDA labeling and updates.

Consult the manufacturer’s professional resources for device instructions and patient materials: Novo Nordisk offers product and device information for clinicians.

Health Canada maintains a searchable database of approved medicines: Drug Product Database lists Canadian approvals and product monographs.

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Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.