Diprivan® Injection for General Anesthesia

Propofol is an intravenous anesthetic used for general anesthesia and procedural sedation. This page outlines clinical uses, safety, and procurement options so facilities can plan; it also helps you review Propofol price without insurance. Ships from Canada to US.

What Diprivan Is and How It Works

Diprivan® (propofol) is a sedative-hypnotic emulsion for intravenous use. It is indicated for induction and maintenance of general anesthesia in adults and certain pediatric patients, for sedation during monitored anesthesia care in adults, and for the sedation of intubated, mechanically ventilated adults in the intensive care unit. The medicine enhances inhibitory neurotransmission at the GABA-A receptor, resulting in hypnosis and amnesia. Onset is rapid and effects are titratable to the desired clinical depth.

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The product is supplied as a white, oil-in-water emulsion that contains soybean oil, glycerol, and egg lecithin. Facilities must use strict aseptic technique to reduce contamination risk. The concentration commonly referenced on labeling is 10 mg/mL.

Who It’s For

This therapy is for use by trained anesthesia professionals in hospitals or surgical centers. It is used to induce and maintain general anesthesia in adults and eligible pediatric patients per the approved label, and to sedate intubated, mechanically ventilated adults in the ICU. It is also used for procedural sedation in adults under monitoring.

Do not use in patients with a known hypersensitivity to this medicine or to its components such as egg or soy products. It is not recommended for obstetric anesthesia or for pediatric ICU sedation. Use caution in elderly, hypovolemic, or hemodynamically unstable patients, and in those with disorders of lipid metabolism. Always follow the official label and institutional protocols.

Dosage and Usage

This treatment is administered intravenously by anesthesia-trained clinicians. Induction typically uses small boluses titrated to loss of consciousness, followed by either intermittent boluses or continuous infusion to maintain an adequate depth of anesthesia. For monitored anesthesia care, clinicians slowly titrate to effect while continuously monitoring airway, ventilation, and hemodynamics. Adult ICU sedation is delivered by infusion with frequent reassessment of sedation goals.

Use a dedicated IV line where feasible. Maintain aseptic technique when spiking vials or connecting infusion systems. Do not mix with blood products, and avoid co-administration with incompatible solutions in the same line. Infusion sets and opened containers have limited in-use times per labeling and institutional policy; discard unused portions as directed. Needle and device selection follows facility standards; for general needle information, see BD Needles.

Strengths and Forms

Availability may vary by manufacturer and lot. Common presentations include single-use vials and larger infusion vials of the emulsion.

• Standard concentration: 10 mg/mL (per labeled presentations)
• Common vial sizes: 20 mL, Propofol 50ml, and Propofol 100ml depending on supplier
• Supplied by manufacturers such as Baxter, Hospira, Braun, Sandoz, or Pfizer

Check current listings for which vial sizes are in stock. The 10 mg/mL reference appears on most labels; confirm package inserts for exact presentations.

Missed Dose and Timing

Missed doses do not apply because this medicine is administered by qualified clinicians for procedures or ICU sedation. If scheduling changes occur, the anesthesia team will adjust timing and dosing according to clinical need and the official label.

Storage and Travel Basics

Store unopened vials at controlled room temperature as directed on the label. Protect from light and do not freeze. Once a vial is opened or an infusion system is connected, follow in-use time limits and discard any remaining product according to the package insert and facility policy. Keep products in their original cartons to preserve labeling and lot traceability.

On receipt, inspect vials for cracks, leaks, or emulsion separation. Do not use if the emulsion is discolored or shows visible phase separation. Secure products in locked medication storage away from unauthorized access. When transporting between clinical sites, carry original documentation and keep supplies upright to prevent damage. Dispose of used needles and IV components in approved sharps containers.

Benefits

This anesthetic allows rapid induction and smooth maintenance, with titration to the desired depth for procedures or ICU sedation. Clinicians value predictable onset, controllable recovery, and compatibility with balanced anesthesia techniques. The emulsion can reduce injection discomfort by proper technique and adjuncts per guidelines, and its pharmacologic profile supports consistent operating room workflows.

Side Effects and Safety

• Injection-site pain or burning
• Hypotension, bradycardia, or other hemodynamic changes
• Apnea or hypoventilation
• Nausea and vomiting
• Rash or pruritus

Serious risks include profound respiratory depression, severe hypotension, or anaphylactoid reactions. Prolonged or high-dose infusions, especially with critical illness, have been associated with propofol infusion syndrome, characterized by metabolic acidosis, rhabdomyolysis, cardiac failure, and renal impairment. Strict aseptic technique is essential because lipid emulsions support microbial growth. Use only where resuscitation equipment and airway management expertise are immediately available. When used with insulin or sulfonylureas, monitor for hypoglycemia as part of overall perioperative management.

Drug Interactions and Cautions

Other CNS depressants, including opioids, benzodiazepines, or inhaled anesthetics, can enhance sedative and cardiorespiratory effects. Alcohol has additive CNS depression. Antihypertensives and beta blockers may increase the likelihood of hypotension; review chronic therapies such as Nadolol during preoperative assessment. Valproate and certain anticonvulsants may alter anesthetic requirements. Do not combine in the same line with incompatible solutions. Review the full label for comprehensive interaction information.

What to Expect Over Time

Induction usually occurs quickly after IV administration. Depth of anesthesia or sedation is then adjusted to clinical goals, with continuous monitoring and supportive care. After procedures or when an infusion stops, recovery may occur as the effect dissipates. Patients can experience transient drowsiness, dizziness, or nausea. Facilities should provide standard post-anesthesia instructions and ensure patients are escorted and monitored according to local protocol. Individual responses vary; follow the official label and clinical standards.

Compare With Alternatives

Facilities may consider inhalational agents or other IV sedatives depending on the clinical setting. For volatile maintenance anesthesia, see Isoflurane. For an alpha-2 agonist option used for monitored sedation under appropriate supervision, compare with Dexmedesed Vial. These agents differ in onset, hemodynamic effects, recovery profiles, and monitoring requirements. Discuss choices with your anesthesia team and consult labeling for each medicine.

If comparing branded and generic pricing, evaluate Diprivan price versus equivalent presentations from other suppliers, taking into account concentration, vial size, and procurement policies.

Pricing and Access

Facilities can review current Propofol price on the product page after account sign-in. Listings reflect Canadian pharmacy fulfillment and Propofol Canadian pricing, with transparent product details before checkout. You can upload required prescriptions and request documentation for your records. US shipping from Canada is available where permitted.

Pricing can vary by vial size, supplier, and quantity. Compare unit costs by mL and plan orders that align with anticipated case volumes. Cash-pay and self-pay institutional purchases may benefit from consolidated ordering to reduce per-shipment overhead. For additional documentation or product verification, contact customer support via your account.

Availability and Substitutions

Supply can fluctuate by lot and manufacturer. If a specific size is unavailable, your prescriber or pharmacy may recommend a clinically appropriate alternative presentation or supplier. Common vial sizes include 20 mL, 50 mL, and 100 mL, with Propofol 100ml often used for longer cases or ICU infusion. When ordering for veterinary practice, browse related options under Pet Medications to keep species-specific use separate.

Patient Suitability and Cost-Saving Tips

Not every patient is a candidate. Those with hypersensitivity to components, unstable hemodynamics, or certain metabolic disorders may require different anesthetic plans. Pediatric indications are age-specific; defer to labeling and institutional policy. For facility budgeting, evaluate the Cost of propofol per case and consider multi-vial orders that match procedure counts. Multi-month planning and scheduled reorders can help maintain continuity. You can enable refill reminders within your account to avoid last-minute shortages. Consider bundling other frequently used injectables, such as Furosemide Injection, to streamline procurement cycles.

Questions to Ask Your Clinician

• Sedation goals: What depth and monitoring plan fit this procedure?
• Airway plan: How will ventilation and oxygenation be managed?
• Hemodynamic strategy: How will hypotension or bradycardia be addressed?
• Allergy risk: Any concern for egg, soy, or emulsion components?
• ICU use: What safeguards reduce prolonged-infusion complications?
• Recovery plan: What observations are needed before discharge from PACU?
• Procurement: Which vial sizes best match anticipated case volume?

Authoritative Sources

• FDA DailyMed: Diprivan (propofol) Injection
• Manufacturer Prescribing Information
• Health Canada Drug Product Database: Propofol

You can place a facility order, upload a valid prescription, and receive prompt US delivery from Canada with temperature-controlled handling when required. Information above is educational and not a substitute for the official label or clinical judgment.