Vyzulta® Ophthalmic Solution for Open-Angle Glaucoma

This prescription prostaglandin analog eye drop lowers intraocular pressure in open-angle glaucoma and ocular hypertension. This page explains dosing, safety, storage, and access details, with US shipping from Canada and ways to save without insurance. Use the information below to prepare for treatment, compare options, and plan refills.

What Vyzulta Is and How It Works

Vyzulta® contains latanoprostene bunod, a nitric oxide-donating prostaglandin analog. After instillation, it converts to latanoprost acid and a nitric oxide donor. The therapy increases aqueous humor outflow through the uveoscleral pathway and by relaxing the trabecular meshwork. Reducing outflow resistance helps lower intraocular pressure, an important goal in glaucoma management.

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This medicine is supplied as a sterile eye drop and is typically dosed once in the evening. Do not exceed the recommended daily schedule unless instructed by a clinician.

Who It’s For

This treatment is indicated to reduce intraocular pressure in adults with open-angle glaucoma or ocular hypertension. It should not be used by anyone with a known hypersensitivity to its components. Use caution in eyes with active intraocular inflammation. Patients who are aphakic or pseudophakic with a torn posterior lens capsule, or who have a history of macular edema, may be at increased risk and should discuss therapy with a healthcare professional. Safety in pediatric patients has not been established. Discuss pregnancy and breastfeeding considerations with a prescriber.

Dosage and Usage

Instill one drop into the affected eye or eyes once daily in the evening. Do not administer more than once per day. Separate this product from other ophthalmic medicines by at least 5 minutes; apply any eye ointment last. Avoid touching the dropper tip to the eye, eyelid, or any surface.

Remove contact lenses before dosing and wait at least 15 minutes before reinsertion. Gentle eyelid closure or nasolacrimal occlusion for 1 to 2 minutes after instillation may help limit systemic absorption and reduce irritation.

Strengths and Forms

Ophthalmic solution 0.024% in a multi-dose 2.5 mL bottle. Availability and packaging may vary by dispensing pharmacy.

Missed Dose and Timing

If a dose is missed, skip it and resume the regular schedule the next day. Do not instill extra drops to make up a missed dose. Keep dosing to the evening unless a prescriber advises otherwise.

Storage and Travel Basics

Store upright at controlled room temperature as directed on the label, typically 2 to 25°C. Protect from light and keep the cap tightly closed. Do not freeze. Keep out of reach of children and avoid contamination of the tip.

For travel, keep the bottle in original packaging with the prescription label. Place it in your carry-on to avoid temperature extremes. You can bring a spare bottle and a copy of the prescription. For international trips, confirm airline and security rules in advance.

Benefits

• Once-daily schedule: evening dosing supports consistency
• Dual-pathway effect: uveoscleral and trabecular outflow
• Adjunct use: may be combined with other classes when prescribed
• Familiar class: prostaglandin analog experience in adults
• Multi-dose bottle: designed for precise drop delivery
• Informed use: counseling covers iris and eyelash changes

Side Effects and Safety

• Eye redness
• Irritation or discomfort
• Eye pain or stinging
• Blurred vision after dosing
• Itching or dry eye
• Eyelash growth or thickening
• Darkening of eyelids or periocular skin
• Increased brown iris pigmentation
• Foreign body sensation
• Headache

Serious or rare effects include macular edema, uveitis, or bacterial keratitis from tip contamination. Iris color changes are usually permanent; eyelash and eyelid changes may be reversible after discontinuation. Seek urgent care for sudden vision changes, eye trauma, severe pain, or signs of infection. Avoid use during active ocular inflammation unless directed by a clinician.

Drug Interactions and Cautions

Topical drug interactions are limited. Using more than one prostaglandin analog at the same time may blunt pressure-lowering effects. Other classes can be used when prescribed, separated by at least 5 minutes, such as carbonic anhydrase inhibitors like Dorzolamide Ophthalmic Solution or beta blockers like Timolol Maleate Ophthalmic Solution. Remove soft contact lenses before dosing and wait 15 minutes before reinserting because preservatives can be absorbed by lenses.

What to Expect Over Time

Clinicians track intraocular pressure at follow-up visits and adjust overall therapy as needed. Vision may not noticeably change day to day, even as pressure declines. Consistent evening dosing and clean technique support long-term control. Any brown iris color change tends to be permanent; eyelid or eyelash changes may lessen after the therapy is stopped under medical guidance.

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Compare With Alternatives

Alternatives include prostaglandin analogs and other classes. Examples are bimatoprost solution such as Lumigan RC and the alpha agonist brimonidine such as Alphagan Ophthalmic Solution. Choice depends on pressure goals, tolerability, and adjunct needs under clinician guidance. For those evaluating costs, a Vyzulta ophthalmic solution price comparison may reflect class differences, bottle size, and fill quantity.

Pricing and Access

We list current Vyzulta ophthalmic solution price and available fill sizes on this page. Orders are dispensed by licensed Canadian pharmacies and Ships from Canada to US with prescription verification. Payment is transparent, and checkout is encrypted. To review current offers and educational savings notes, visit Promotions.

Availability and Substitutions

Supply can vary by pharmacy partner. If the product is unavailable, a prescriber may recommend an alternative within or outside the prostaglandin class. When relevant, a Vyzulta manufacturer coupon alternative may include cross-border pricing strategies or professional program support. Restock dates are not guaranteed or posted.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with open-angle glaucoma or ocular hypertension who can follow a nightly dosing routine and accept potential class effects. It may not be ideal for those with active uveitis, risk of macular edema, or prior hypersensitivity. Pediatric use has not been established.

To reduce expenses, consider multi-month fills when appropriate, maintain one dispensing pharmacy, and set refill reminders. Ask about combining different classes rather than duplicating prostaglandins. Plan for Vyzulta eye drops out of pocket by reviewing refill frequency and bottle quantities with the prescribing clinician.

Questions to Ask Your Clinician

• Is this therapy appropriate for my type of glaucoma or ocular hypertension?
• What intraocular pressure target is planned for my treatment?
• How often should pressure be checked while using these drops?
• How should I space this with other prescribed eye drops?
• What iris or eyelash changes are possible and how are they monitored?
• What should I do if persistent irritation occurs after dosing?

Authoritative Sources

• Vyzulta Official Site
• DailyMed: Vyzulta
• Health Canada DPD

You can check out now for express US delivery from Canada with temperature-controlled handling when required. This content is informational and does not replace the approved label or advice from a licensed healthcare professional.