What is insulin glargine?

Insulin glargine, also known by the brand name Lantus, is a long-lasting basal insulin analog that is taken once per day to help control blood sugar levels in those suffering from diabetes. It gradually secretes insulin, so its effects last between 18 and 26 hours. Its effects on the body are similar to those of basal insulin in non-diabetic pancreatic beta cells. It may also be used in combination with a fast-acting insulin.

What is insulin degludec?

Insulin degludec is an ultra-long-acting basal insulin analog that is approved for use in adults with type 1 and type 2 diabetes. It is administered by injection once per day to help control the blood sugar levels of those with diabetes. The effects of insulin degludec last up to 42 hours. This insulin is also marketed under the name Tresiba.

Differences and similarities between insulin glargine and insulin degludec


Tresiba, although a popular insulin, was only released back in 2016. Lantus, on the other hand, was released in 2000. While Tresiba is also slightly more expensive compared to Lantus, it is also 50% less likely to cause hypoglycemia. Compared to insulin glargine, insulin degludec also proved to be more predictable in controlling blood sugar. Insulin glargine, however, can lower A1c by up to 2 to 3%. Lantus is also considered safe for use in people with kidney or liver problems.


Both insulin medications may cause slight weight gain. Both Lantus and Tresiba are injectable drugs and you must monitor your blood sugar regularly. Dosing with either medication is easy to customize and should be taken once daily.

Disclaimer: Please note that the contents of this community article are strictly for informational purposes and should not be considered as medical advice. This article, and other community articles, are not written or reviewed for medical validity by Canadian Insulin or its staff. All views and opinions expressed by the contributing authors are not endorsed by Canadian Insulin. Always consult a medical professional for medical advice, diagnosis, and treatment.