Kazano and Nesina – Which is Better?

Publish On Diabetes By CanadianInsulin

Kazano and Nesina

Kazano and Nesina are two popular medications used to treat type 2 diabetes. While they have similarities in usage and effects on blood sugar levels, differences in these medications can impact diabetes treatment decisions.


More About Kazano

Kazano is a prescription medication that contains two active ingredients, Alogliptin and Metformin. Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which increases the levels of incretin hormones in the body, regulating blood sugar levels. Metformin is a commonly used antidiabetic drug that reduces glucose production in the liver and improves insulin sensitivity.

The combination of alogliptin and metformin in Kazano targets different mechanisms related to glucose metabolism, helping improve blood sugar control in individuals with type 2 diabetes. It is important to note that Kazano is prescribed a proper diet and exercise.


More About Nesina

Nesina is also a prescription drug for type 2 diabetes, containing the active ingredient alogliptin. Nesina is typically prescribed with diet and exercise to maximize glycemic control in type 2 diabetes patients. It can be used alone or in combination with other antidiabetic medications, depending on individual health needs and response to treatment.

It is essential to note that Nesina is the brand name for Alogliptin, which is a standalone medication and not a combination like Kazano.


Efficacy of Kazano and Nesina

The FDA has approved Kazano based on four clinical studies involving over 2,500 type 2 diabetes patients. These studies showed reductions in HbA1c of 1.1% over Nesina and 0.5% over metformin after 26 weeks.

Nesina has also demonstrated efficacy and safety in 14 clinical trials involving 8,500 type 2 diabetes patients. The results showed reductions in HbA1c of 0.4% to 0.6% after 26 weeks.


Dosage and Administration

Kazano has different strengths: 12.5 mg alogliptin and 500 mg metformin, and 12.5 mg alogliptin and 1000 mg metformin. Type 2 diabetes patients are required to take two doses of Kazano daily with food. ptients can adjust the dosage but should not exceed the recommended daily use of 25 mg alogliptin and 2000 mg metformin.

Nesina, on the other hand, is typically taken at a recommended dose of 25 mg once daily. Unlike Kazano, Nesina can be taken with or without food.


Cost Difference

The cost of Nesina and Kazano in the USA may vary depending on several factors, such as the pharmacy, location, and insurance coverage. Nesina’s average retail price for 28 tablets is around $174. On the other hand, the average retail price for Kazano starts at approximately $166.80 for 56 tablets.

However, Kazano costs $119.99 (12.5/1000 mg) for 56 tablets, while Nesina costs $93.65 – $96.56 for 28 pills if you purchase it from reputed Canadian pharmacies and online sites such as canadianinsulin.com. 


Side Effects

Common side effects of Kazano include diarrhea, upset stomach, severe headache, blurry vision, back pain, joint pain, nausea, and loss of appetite. Nesina may cause side effects such as headache, stuffy nose, sore throat, joint pain, shortness of breath, tiredness, loss of appetite, and weight gain.


Considerations for Choosing between Kazano and Nesina

When choosing between Kazano and Nesina, it is essential to consider individual factors such as medical history and current health status. Using these medications under the guidance and supervision of a healthcare professional who can determine the appropriate dosage and treatment plan based on individual health factors is crucial. Regular monitoring of effectiveness and safety in managing diabetes is also necessary.

Remember to consult with a healthcare professional for personalized advice and guidance regarding using Kazano and Nesina for treating type 2 diabetes.