Contrave® ER Tablets for Chronic Weight Management

What Contrave Is and How It Works

Contrave® combines naltrexone and bupropion in an extended-release tablet for long-term weight management in adults. It supports reduced-calorie diet and increased physical activity. This guide explains safe use, common effects, and access options with US delivery from Canada.

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This medicine targets appetite control and reward pathways in the brain. Naltrexone acts on opioid receptors, while bupropion influences dopamine and norepinephrine. Together, the treatment may help reduce hunger and food cravings. Swallow tablets whole, since the release profile is designed for steady levels through the day.

Many patients use the class over months as part of a broader plan. Diet quality, sustained activity, and routine follow-up support results. For additional context on diet planning alongside pharmacotherapy, see GLP 1 Medications and Weight Management resources on our site.

Some users refer to the product as Naltrexone bupropion ER 8mg/90mg tablets. The active components and dosage form are the same. Your prescriber will determine if the combination fits your health profile.

Who It’s For

This therapy is indicated as an adjunct to diet and exercise for chronic weight management in adults with obesity, or in adults who are overweight with at least one weight-related condition. It is not for use in children. People with seizure disorders, current or recent opioid use, uncontrolled hypertension, a history of bulimia or anorexia, or those taking monoamine oxidase inhibitors should not use this medicine. Do not use during pregnancy. Discuss breastfeeding with your clinician.

Review your full medical history, including mood disorders, glaucoma risk, liver disease, kidney disease, and alcohol use. Your healthcare professional may monitor blood pressure and heart rate during treatment.

Dosage and Usage

Follow the dosing schedule from the official label. Tablets are taken by mouth and swallowed whole. Do not cut, crush, or chew. A typical schedule titrates over several weeks to a maintenance dose. Avoid taking doses with high-fat meals, which may increase seizure risk. Separate morning and evening doses.

One label-based regimen escalates in weekly steps toward two tablets twice daily by the fourth week. Take doses at least several hours apart. If you experience persistent adverse effects during titration, contact your prescriber for guidance. Some patients use pill organizers and phone reminders to support adherence.

Product listings sometimes describe the schedule as Contrave tablet ER 12hr 8mg/90mg. Always rely on the official package insert for exact timing and limits.

If your clinician recommends ongoing therapy, maintain the diet and activity plan that complements the medicine. Routine follow-up helps evaluate tolerability and progress.

Strengths and Forms

The product is an extended-release oral tablet combining naltrexone hydrochloride and bupropion hydrochloride. Commonly supplied strength is 8 mg/90 mg per tablet. Availability may vary by pack size and pharmacy partner.

We list formats such as Contrave ER 8 90 mg 120 tablets. Pack sizes differ by supplier and may change over time.

Missed Dose and Timing

If you miss a dose, skip it and take the next dose at the usual time. Do not double up to make up for a missed tablet. Keep doses spaced through the day as directed. If you miss multiple doses, speak with your prescriber about how to resume safely.

Storage and Travel Basics

Store tablets at room temperature in the original container, away from excess moisture. Keep the bottle tightly closed and out of reach of children and pets. Do not store in a bathroom. When traveling, carry your medicine in hand luggage with a copy of your prescription. Keep labels visible for security checks. Use a reminder system to maintain timing across time zones, and avoid storing tablets in hot vehicles.

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Pen Handling and Sharps Disposal

This product is supplied as tablets. No pen devices or sharps disposal steps are required.

Benefits

This combination therapy may help reduce appetite and limit cravings when used with diet and activity changes. The extended-release design supports twice-daily dosing. Many people find a structured titration helps settle into a routine. The tablet form avoids injections and can fit standard medication organizers.

Side Effects and Safety

• Nausea or vomiting
• Headache
• Constipation or diarrhea
• Dizziness
• Dry mouth
• Insomnia

Serious risks can include increased blood pressure or heart rate, seizures, mood changes or suicidal thoughts, liver problems, angle-closure glaucoma, and allergic reactions. Stop the medicine and seek urgent care for severe symptoms, including seizures, fainting, yellowing of the skin or eyes, or signs of an allergic reaction. This product carries a boxed warning related to suicidal thoughts and behavior associated with antidepressants. Report concerning mood or behavior changes to your prescriber right away.

Drug Interactions and Cautions

Do not use with opioids due to risk of precipitated withdrawal and reduced analgesia. Avoid monoamine oxidase inhibitors within 14 days of therapy. Bupropion is a CYP2D6 inhibitor and can raise levels of certain antidepressants, antipsychotics, beta-blockers, and antiarrhythmics. Use caution with drugs that lower the seizure threshold, including other bupropion-containing products. Alcohol can increase certain risks; discuss use with your clinician. Tell your prescriber about all medicines, vitamins, and herbal products you take.

What to Expect Over Time

Early on, you may notice changes in appetite or cravings. Some side effects, like nausea or headache, can occur during dose escalation and may lessen as your body adjusts. The treatment is intended for ongoing use alongside nutrition and activity plans. Your healthcare professional may reassess whether the therapy remains appropriate as your goals and tolerability evolve. Keep logging meals, movement, and how you feel to support balanced decisions.

Compare With Alternatives

Other prescription options for chronic weight management include GLP-1 therapies and gastrointestinal lipase inhibitors. For an injectable GLP-1 option, see Wegovy®. For a non-systemic oral alternative, review Xenical®. Tablet users considering combination therapy sometimes compare these to Contrave ER 8 90mg tablets to discuss fit, preferences, and goals with a prescriber.

Pricing and Access

We connect you to Canadian pharmacy partners for competitive options and transparent listings. You can review Naltrexone/bupropion 8mg 90mg tablets price details on the product page. US patients benefit from Canadian pricing with convenient fulfilment. Ships from Canada to US with clear checkout steps. For general education on lifestyle support, see Superfoods For Weight Loss.

Looking for seasonal offers or bundle opportunities? Check our Promotions page when available. For broader therapy options, explore Weight Loss Medications.

Availability and Substitutions

Supply can vary by partner pharmacy. If a specific pack size is not available, your prescriber may recommend an equivalent alternative or adjust the fill quantity. Do not switch medicines without clinical guidance.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults seeking an oral, non-hormonal option as part of a structured program. It may not suit those with seizure risk, uncontrolled hypertension, active opioid therapy, eating disorders, or pregnancy. Discuss mental health history and current treatments before starting.

To manage out-of-pocket costs, consider multi-month fills if appropriate, which can reduce per-tablet expenses and simplify routines. Set refill reminders before travel or schedule changes. Use one pharmacy source to maintain consistent tablets and labeling. For condition education, see Obesity and browse related topics under Weight Loss.

Questions to Ask Your Clinician

• Is this combination appropriate for my medical history?
• How should I follow the titration schedule?
• What signs mean I should contact you promptly?
• Which other medications or supplements could interact?
• How will we track progress and tolerability?
• What nutrition and activity plan should I follow?
• Are multi-month fills a good option for me?

Authoritative Sources

Ready to proceed? You can order today with US shipping from Canada and prompt, express, temperature-controlled handling when required. This information is not a substitute for medical advice; always follow your prescriber and the official label.