Contrave, a brand name for the combination of bupropion and naltrexone, is a prescription weight-loss medication developed by Orexigen Therapeutics. Approved by the FDA in 2014, Contrave is intended for use in adults with obesity or overweight individuals with weight-related medical problems. Bupropion, an antidepressant, and naltrexone, an opioid antagonist, work together to reduce hunger and control cravings. This dual-action approach targets the brain’s reward system and appetite regulation centers, aiding in weight management. Contrave is typically taken as an oral tablet, with dosing gradually increased over several weeks. Patients using Contrave should follow their prescribed regimen and maintain regular consultations with their healthcare provider to monitor progress and manage any potential side effects or interactions with other medications.