Hyzaar® Tablets for High Blood Pressure

Hyzaar® is a prescription tablet that treats high blood pressure. It combines losartan with hydrochlorothiazide to help lower readings. This page explains how it works, safety basics, and how you can order from Canada with US delivery, even without insurance.

What Hyzaar® Is and How It Works

Hyzaar® contains two medicines in one tablet. Losartan is an angiotensin II receptor blocker, or ARB. It relaxes blood vessels by blocking angiotensin II at the AT1 receptor. Hydrochlorothiazide is a thiazide diuretic. It helps your body remove extra salt and water through the kidneys. Together, they reduce pressure on blood vessel walls and lower blood pressure more than either alone. At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

Many adults need more than one medicine to control hypertension. A fixed-dose combination like Hyzaar can simplify treatment. It supports adherence with one daily tablet. If you live in the US, you can access Canadian pricing with US delivery from Canada.

Hyzaar is generally used after a single agent does not control blood pressure. It may also be considered as initial therapy when blood pressure is significantly elevated. Follow your prescriber’s plan and the official label.

For related treatment options and guidance, see our High Blood Pressure category and our condition page for Hypertension.

Who Hyzaar® Is For

Hyzaar is indicated for adults with hypertension. It helps lower blood pressure when losartan or a diuretic alone is not enough. It can also be used in patients likely to need multiple medicines for control.

Do not use Hyzaar if you cannot make urine. Do not use it during pregnancy. Avoid it with aliskiren if you have diabetes. People with severe kidney or liver problems need careful monitoring. Tell your clinician if you had angioedema with an ACE inhibitor or an ARB. Discuss sulfonamide allergy history because hydrochlorothiazide is a sulfonamide.

Dosage and Usage

Hyzaar is taken by mouth once daily, with or without food. Many adults start at 50 mg/12.5 mg daily. Your clinician may increase the dose after 2 to 4 weeks, based on response.

• Typical starting dose: 50 mg losartan / 12.5 mg hydrochlorothiazide once daily
• Usual titration: increase after 2 to 4 weeks if needed
• Maximum recommended dose: 100 mg / 25 mg once daily

Swallow tablets with water. Try to take it at the same time each day. Morning dosing may reduce nighttime urination. Your prescriber may adjust timing to fit your routine and labs. Always follow the official label and your clinician’s advice.

Strengths and Forms

Hyzaar is supplied as oral tablets in several fixed-dose strengths. Availability can vary by supplier and country.

Your prescriber chooses a strength that matches your blood pressure goals and prior therapy.

Missed Dose and Timing

If you miss a dose, take it when you remember on the same day. If it is close to the next dose, skip the missed dose. Do not take two doses at once. Keep a daily reminder to help you stay on schedule.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep them in the original container, tightly closed. Protect from moisture and excessive heat. When traveling, carry your medicine in your hand luggage with a copy of your prescription. Avoid pill organizers that expose tablets to humidity unless they seal well.

Benefits

• Two proven medicines in one daily tablet
• Greater blood pressure reduction than either drug alone
• Streamlined regimen that supports adherence
• ARB component with lower risk of cough than ACE inhibitors
• Diuretic component helps reduce fluid-related blood pressure effects

Side Effects and Safety

• Dizziness or lightheadedness, especially when starting or increasing dose
• Increased urination, usually early in therapy
• Headache or fatigue
• Cough or upper respiratory symptoms
• Muscle cramps
• Low blood pressure symptoms
• Electrolyte changes, including potassium or sodium shifts
• Photosensitivity or rash
• Gout flare in susceptible individuals

Serious effects are less common but can occur. These include kidney function changes, severe electrolyte imbalance, angioedema, and very low blood pressure. Hyzaar can harm an unborn baby. It should not be used during pregnancy, and it should be stopped as soon as pregnancy is detected. Discuss breastfeeding with your clinician, as thiazides may affect milk production.

Seek urgent care for facial swelling, trouble breathing, fainting, or signs of severe dehydration.

Drug Interactions and Cautions

• Do not combine with aliskiren if you have diabetes
• Dual renin-angiotensin system blockade is generally not recommended
• NSAIDs may reduce effect and raise kidney risk
• Potassium supplements, salt substitutes, or potassium-sparing diuretics may raise potassium
• Other blood pressure medicines can cause additive effects
• Lithium levels may rise; toxicity risk increases
• Alcohol can increase dizziness or low blood pressure
• Bile acid resins can reduce hydrochlorothiazide absorption
• Monitor blood sugar closely if you have diabetes

Tell your clinician about all medicines, vitamins, and herbal products you use. For more on ACE inhibitor options, see Ramipril Uses.

What to Expect Over Time

Blood pressure usually starts improving within the first week. Full effect often appears after several weeks of regular use. Your clinician may check labs to monitor kidney function and electrolytes. Dose adjustments can follow if targets are not met. Combining lifestyle changes with medicine can support long-term control.

If your plan changes, your clinician may adjust components rather than stopping therapy outright. For additional reading on beta-blockers used in some plans, see How Bystolic Helps.

Compare With Alternatives

Many patients start with a single agent like an ARB or an ACE inhibitor. If one drug is not enough, a combination like Hyzaar can help. Alternatives include ARB monotherapy, another ARB plus thiazide, or an ACE inhibitor.

Losartan alone, branded as Cozaar®, may suit those who cannot tolerate a diuretic. Another ARB and thiazide option is Diovan Hct®. Your prescriber will select therapy based on your readings, labs, and history.

Pricing and Access

You can buy Hyzaar online with Canadian pricing and US shipping. Many customers compare Hyzaar cost and Hyzaar price across strengths, then choose a multi-month supply. View current pricing, check availability, and place your order when ready.

We provide secure, encrypted checkout. US delivery from Canada is available with prescription verification. If you pay cash, you may still find meaningful savings without insurance. For a personalized estimate, start your order and upload your prescription.

Availability and Substitutions

Stock and packaging can vary. If a specific strength is unavailable, your prescriber may suggest a therapeutic alternative or a different strength. An ACE inhibitor such as Lisinopril may be considered if an ARB is not suitable. Pharmacist substitution depends on your prescription and local rules.

To browse related options, explore our Heart Health Medications section.

Patient Suitability and Cost Saving Tips

Hyzaar may be suitable if:

• You have hypertension not controlled on a single medicine
• You need a once-daily ARB and thiazide combination
• You prefer a simplified pill burden

Hyzaar may not be right if:

• You are pregnant or planning pregnancy
• You cannot make urine or have severe kidney disease
• You had angioedema with ACE inhibitors or ARBs
• You have severe liver impairment without close monitoring

Cost-saving tips:

• Ask your clinician about a 90-day supply to reduce per-tablet cost
• Set refill reminders so you never miss doses
• Keep your lab appointments to avoid urgent visits
• Discuss generic options when appropriate

Questions to Ask Your Clinician

• Is Hyzaar the right combination for my blood pressure goals?
• Which strength should I start with, and when should we adjust?
• What labs will you monitor and how often?
• Should I take my dose in the morning or evening?
• Do I need to change my potassium or sodium intake?
• How should we manage other blood pressure medicines I take?
• What signs of low blood pressure or dehydration should I watch for?

Authoritative Sources

• FDA DailyMed
• Manufacturer Prescribing Information
• Health Canada DPD

Ready to get started? Place your Hyzaar order for US delivery from Canada. Always use Hyzaar as prescribed. This page is educational and does not replace professional medical advice.