Dabigatran

Use of Dabigatran

Mechanism of Action

Precautions and Warnings

• Avoid Dabigatran in individuals with a history of hypersensitivity to the medication.
• Use caution in patients with renal impairment, as dosage adjustments may be necessary to prevent excessive anticoagulation.
• Inform healthcare providers about any ongoing medications, particularly other anticoagulants, to minimize the risk of drug interactions.
• Dabigatran should be used with caution in patients at an increased risk of bleeding, such as those with a history of gastrointestinal bleeding or recent surgery.

Dosage

• For stroke prevention in atrial fibrillation, the typical dose is 150 mg orally twice daily, with adjustments for renal function.
• In the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), the initial dose is 150 mg twice daily after a period of parenteral anticoagulation.

Side Effects

• Gastrointestinal discomfort
• Nausea
• Dyspepsia
• Bleeding
• Bruising
• Rash
• Liver enzyme elevation