Janumet XR® Tablets for Type 2 Diabetes

What Janumet XR Is and How It Works

Janumet XR is a prescription oral medicine for adults with type 2 diabetes. It combines sitagliptin, a DPP-4 inhibitor, with extended-release metformin, a biguanide. This page explains key facts to help you compare options and order with US shipping from Canada without insurance.

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Sitagliptin helps your body increase insulin release after meals and reduces glucagon levels by protecting incretin hormones from breakdown. Metformin decreases liver glucose production and improves insulin sensitivity. Together, the treatment can lower fasting and post-meal blood glucose as part of a broader plan that includes diet and exercise. For additional background on treatment categories, see the non-insulin Combination Tablets section of our catalog.

Who It’s For

This medicine is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. It may be used in patients not adequately controlled on metformin alone, sitagliptin alone, or those already taking both components.

It is not for type 1 diabetes or diabetic ketoacidosis. People with significant renal impairment, metabolic acidosis (including lactic acidosis), or known hypersensitivity to sitagliptin or metformin should avoid use. Discuss your condition history and kidney function with your clinician. For condition education, review our Type 2 Diabetes overview.

Dosage and Usage

Follow your prescriber’s directions and the product’s official labeling. The extended-release formulation is generally taken once daily with a meal to reduce stomach upset. Swallow tablets whole. Do not crush, cut, or chew.

When switching from separate sitagliptin and metformin products, your prescriber may choose a comparable total daily dose. If you are new to metformin, a gradual dose escalation may be used to improve gastrointestinal tolerability. If you see a shell-like tablet in your stool, that is expected with some extended-release designs and does not mean the medicine did not work.

If you need detailed administration tips, read our concise Dosage Guide and consult your healthcare provider for individualized instructions.

Strengths and Forms

This product is supplied as extended-release oral tablets. Each Janumet XR® tablet contains sitagliptin and metformin HCl ER; commonly available strengths include 50/500 mg, 50/1000 mg, and 100/1000 mg. Availability can vary by pharmacy and stock.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is close to your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle tightly closed and away from moisture. Use the original container with the label for easy identification.

When you travel, pack your medication in a carry-on bag. Keep a copy of your prescription and a medication list. Avoid excessive heat, and do not store tablets in a car glove box. Keep out of reach of children and pets.

Pen Handling and Sharps Disposal

This is an oral tablet, not an injection. No pen priming or sharps disposal is required.

Benefits

The combination of a DPP-4 inhibitor and extended-release metformin targets glucose control through complementary mechanisms. Many patients appreciate once-daily dosing and the gastrointestinal tolerability profile relative to immediate-release metformin. The treatment can be used alone or with other antihyperglycemic agents when appropriate.

Because this class does not directly stimulate insulin release, the risk of hypoglycemia is generally low when used without insulin or insulin secretagogues. The regimen can support A1C reduction as part of a comprehensive plan that includes diet, exercise, and regular glucose monitoring.

Side Effects and Safety

• Stomach upset or diarrhea: typically mild and often improves with continued use
• Nausea or abdominal discomfort: may lessen when taken with food
• Headache or upper respiratory symptoms: usually transient
• Weakness or dizziness: report persistent symptoms to your clinician

Serious but rare risks include lactic acidosis with metformin, pancreatitis with sitagliptin, severe allergic reactions, bullous pemphigoid, severe joint pain, and worsening kidney function. Seek urgent care for severe abdominal pain, persistent vomiting, unusual muscle pain, trouble breathing, or swelling of the face or throat. Hypoglycemia can occur when combined with insulin or sulfonylureas; monitor glucose and recognize signs such as sweating, shakiness, and confusion.

For an overview of metformin-related risks, including lactic acidosis, see our educational article on Lactic Acidosis Risks.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements you take. Iodinated contrast agents for imaging may temporarily require drug interruption to reduce lactic acidosis risk. Excessive alcohol intake increases lactic acidosis risk and should be avoided.

Drugs that affect kidney function can change metformin exposure. Some cationic drugs eliminated by the kidney (for example, certain H2-blockers) may interact. Combining with insulin or sulfonylureas can increase hypoglycemia risk; your prescriber may adjust other therapies accordingly. For broader context on therapy choices, read our Diabetes Medications Guide.

What to Expect Over Time

Glucose values may improve with consistent daily use alongside diet and exercise. It can take ongoing adherence and regular monitoring to see stable results. Your clinician may adjust your plan based on home readings, laboratory measures, and tolerability.

Many patients track fasting and post-meal readings and bring logs to appointments. Staying consistent with meals, activity, and dosing time can support stable control. If you and your clinician later consider metformin monotherapy, you may review options such as Glumetza; any change should follow medical advice. For eye health considerations in diabetes, see Metformin and Vision.

Compare With Alternatives

Other fixed-dose combinations may be appropriate based on your history and goals. An SGLT2-inhibitor plus metformin option such as Synjardy may suit patients who would benefit from that class’s mechanism. A DPP-4 inhibitor paired with metformin but using a different agent, such as Jentadueto, is another alternative. Your clinician will align the choice with your kidney function, tolerance, and treatment targets.

Pricing and Access

We list current janumet xr price transparently so you can compare options. If you prefer to see the price of janumet xr before adding to cart, use the product page for full details.

Our platform reflects Canadian pricing with US delivery from Canada. You can browse, upload your prescription, and complete checkout online. If you are looking for special offers, see our rotating Promotions; availability can change without notice.

Availability and Substitutions

Stock can vary. If an item is temporarily unavailable, your prescriber may recommend a therapeutically appropriate alternative in the same class or a different combination. If your clinician approves a switch, we can help coordinate the change during checkout.

If you are comparing options by value, consider total janumet xr cost alongside your care plan and monitoring needs. Alternatives and generics, where appropriate, may offer different price points and dosing schedules.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults who need combination therapy and prefer once-daily extended release. It may not be appropriate for people with advanced kidney disease, unstable heart failure, or a history of pancreatitis without careful evaluation.

To lower out-of-pocket costs, consider multi-month supplies to reduce per-fill fees, set refill reminders, and compare tablet strengths as advised by your clinician. Some patients also look for coupons for janumet; review any terms and bring questions to your prescriber if a change in therapy is needed for affordability.

Questions to Ask Your Clinician

• Therapy goals: A1C target and monitoring plan
• Fit with history: kidney function and pancreatitis risk
• Side effects: what to watch and when to seek care
• Other medicines: interactions and hypoglycemia risk
• Lifestyle plan: meal timing, activity, and adherence tips
• Follow-up: labs and visit intervals

Authoritative Sources

For detailed prescribing information, review the manufacturer’s prescribing information, FDA labeling, or Health Canada details:

• US prescribing information on DailyMed: see official labeling for sitagliptin and metformin combination tablets on FDA DailyMed, official database for drug labels.
• Manufacturer information: consult product documentation at Merck, official product portfolio and resources.
• Canadian listing: verify status using Health Canada Drug Product Database, official search tool.

Order when ready using our secure checkout with prompt, express, temperature-controlled handling when required.

Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.