Alphagan® Ophthalmic Solution for Glaucoma and Ocular Hypertension

Alphagan® Ophthalmic Solution contains brimonidine, an alpha-2 adrenergic agonist that lowers high eye pressure in open-angle glaucoma and ocular hypertension. This page helps you compare options and place an order from Canada, with US delivery from Canada and Canadian pricing that can help if paying cash or without insurance.

What Alphagan® Is and How It Works

Alphagan® is a brimonidine tartrate ophthalmic solution. It reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow. Lowering eye pressure helps reduce the risk of optic nerve damage and vision loss in glaucoma and ocular hypertension.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

Our cross-border service makes it simple to buy Alphagan Ophthalmic Solution online from Canada, with US shipping supported by Canadian pricing. Patients and caregivers often compare Alphagan Ophthalmic Solution 0.2% buy options against Alphagan P eye drops buy offers to choose the right formulation their clinician prescribes.

Who Alphagan® Is For

Alphagan is indicated for adults with open-angle glaucoma or ocular hypertension who need additional intraocular pressure reduction. It may be used alone or alongside other pressure-lowering eye drops when a clinician determines combination therapy is appropriate.

People with narrow-angle glaucoma should be evaluated and treated appropriately before topical agents are used. Infants and young children, especially those under 2 years of age, should not use brimonidine due to the risk of serious adverse effects. Those with severe cardiovascular disease, orthostatic hypotension, severe depression, or kidney or liver impairment need careful assessment before starting therapy. A history of ocular allergy or chronic eye inflammation also warrants caution.

To learn more about the condition, see our Glaucoma category, which provides background on pressure-related eye disease. For patients managing diabetes and eye health, these reads can be helpful: Diabetic Eye Disease, July Is Healthy Vision Month, and Promote Eye Health.

Dosage and Usage

Follow your prescriber’s instructions and the product label. Typical labeled dosing for Alphagan ophthalmic solution is:

• Instill one drop in the affected eye or eyes three times daily, about every 8 hours.
• If used with other topical eye medicines, wait at least 5 minutes between products.
• Use punctal occlusion after each dose. Gently press the inner corner of the eye for 1 to 2 minutes to limit systemic absorption.
• Wash hands before use. Avoid touching the dropper tip to any surface, including the eye or eyelids.

Lens wearers should remove soft contact lenses before instillation and wait at least 15 minutes before reinserting them.

Strengths and Forms

Availability may vary by manufacturer and pharmacy. Commonly referenced brimonidine ophthalmic solutions include:

• 0.2% brimonidine tartrate ophthalmic solution (often referred to as Alphagan)
• 0.15% brimonidine solution (often associated with Alphagan P)
• 0.1% brimonidine solution (another Alphagan P strength)
• Common bottle sizes include 5 mL, 10 mL, and 15 mL, depending on the product

Your prescription specifies the exact strength and bottle size.

Missed Dose and Timing

If a dose is missed, instill it when remembered unless it is almost time for the next dose. In that case, skip the missed dose and resume the regular schedule. Do not double up to make up for a missed dose.

Try to use doses at evenly spaced times each day to maintain consistent pressure control.

Storage and Travel Basics

Store the bottle at room temperature as directed on the label. Keep the cap closed tightly. Protect from excessive heat, moisture, and freezing. Keep out of reach of children.

For travel, carry your eye drops in your hand luggage, in the original labeled bottle. Use a clean case to protect the container. If flying, keep the cap closed to prevent leakage due to pressure changes. You can store your order at home in a cool, dry place that is easy for you to access.

Benefits

• Lowers intraocular pressure in open-angle glaucoma and ocular hypertension
• Can be used alone or with other glaucoma drops when additional pressure reduction is needed
• Small, portable bottle for regular use at home or while traveling
• Well-established alpha-2 adrenergic agonist mechanism

Side Effects and Safety

Common side effects include:

• Eye redness or irritation
• Burning or stinging on instillation
• Dry mouth
• Itchy or watery eyes
• Foreign body sensation
• Headache, dizziness, or fatigue
• Eyelid redness or swelling

Serious reactions are uncommon but can include severe allergic conjunctivitis or blepharitis, significant drowsiness, very low blood pressure, or slow heart rate. Infants and toddlers are at risk for serious breathing and central nervous system effects and must not receive brimonidine. Stop use and seek medical care if severe eye irritation, rash, facial swelling, shortness of breath, fainting, or other alarming symptoms occur.

Drug Interactions and Cautions

Important interaction and precaution considerations include:

• Monoamine oxidase inhibitors are contraindicated due to potential for increased systemic effects.
• Tricyclic antidepressants may reduce the effectiveness of brimonidine or increase side effects.
• Use caution with central nervous system depressants, alcohol, barbiturates, opioids, or sedating antihistamines because of additive drowsiness or dizziness.
• Antihypertensives or cardiac glycosides may have additive blood pressure or heart rate effects.
• Remove soft contact lenses before dosing due to preservative sensitivity; wait 15 minutes before reinsertion.
• Tell your clinician about cardiovascular disease, depression, Raynaud’s phenomenon, orthostatic hypotension, or kidney or liver issues.

Always provide a full medication list to your eye care professional, including over-the-counter products and supplements.

What to Expect Over Time

Brimonidine typically starts lowering pressure within hours of dosing. Pressure control depends on correct use and regular dosing. Many patients use brimonidine with another class, such as a beta blocker or a carbonic anhydrase inhibitor, when additional reduction is required. Eye pressure monitoring guides ongoing therapy decisions.

Compare With Alternatives

Several approved options lower intraocular pressure and may be used alone or in combination. Beta blockers are a common first-line choice. Carbonic anhydrase inhibitors can be used as adjuncts or in those who cannot tolerate other agents.

Two alternatives to discuss with your clinician include Timolol Maleate and Dorzolamide. Combination drops and prostaglandin analogs may also be appropriate in certain cases.

Pricing and Access

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Ready to price options today? Review Alphagan ophthalmic solution price online and related offers. For occasional promos, see our Promotions page.

Availability and Substitutions

Supply can vary by strength and manufacturer. If your exact product is unavailable, your prescriber may recommend a different brimonidine strength or another drug class. Prostaglandin analogs are common alternatives and may be considered when appropriate. One example is Vyzulta®, which your clinician may discuss if it suits your treatment plan.

Patient Suitability and Cost Saving Tips

Alphagan is not appropriate for infants and toddlers. It requires caution in people with significant cardiovascular disease, severe depression, or those taking interacting medicines. Contact lens wearers should follow preservative-related guidance. Patients who have experienced ocular allergy with brimonidine should discuss options before restarting therapy.

To manage cost, consider:

• Asking your clinician if a multi-month supply is appropriate
• Scheduling refills so you never run out
• Comparing buy brimonidine tartrate eye drops options versus Alphagan P 0.1% price when relevant to the prescription
• Reviewing Brimonidine eye drops without insurance details if you pay cash

Questions to Ask Your Clinician

• Is Alphagan the right first-line or add-on choice for my eye pressure goals?
• How should I space Alphagan with my other eye drops?
• What signs of ocular allergy should I watch for?
• When should my eye pressure be rechecked after starting these drops?
• Are there alternatives if redness or dry mouth become bothersome?
• Do my other medicines increase the chance of drowsiness or low blood pressure?

Authoritative Sources

FDA DailyMed

Alphagan P Prescribing Information

Health Canada Drug Product Database

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