Janumet® Tablets for Type 2 Diabetes

Janumet® is a prescription tablet that combines sitagliptin and metformin to help lower blood sugar in adults with type 2 diabetes. This page covers how it works, who it suits, dosing basics, and safety. From Canada, it ships to the US with prompt, express shipping. You can order with Canadian pricing, including options if paying without insurance.

What Janumet® Is and How It Works

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Janumet® pairs two well-studied medicines. Sitagliptin is a DPP-4 inhibitor. It increases levels of incretin hormones like GLP-1 and GIP. These hormones help the pancreas release insulin when glucose rises and reduce glucagon. Metformin is a biguanide. It lowers liver glucose production, improves insulin sensitivity, and decreases intestinal glucose absorption.

The combination targets fasting and post-meal glucose. It supports A1C reduction when used with diet and exercise. Janumet should be taken exactly as prescribed on the label. This page also helps compare strengths and Canadian pricing that ships to the US.

Who Janumet® Is For

Janumet is indicated for adults with type 2 diabetes as an adjunct to diet and exercise. It is not indicated for type 1 diabetes or for diabetic ketoacidosis. Pediatric safety and effectiveness are not established.

Do not use if there is severe kidney disease or metabolic acidosis, including diabetic ketoacidosis. Metformin carries a rare but serious risk of lactic acidosis. Risk increases with significant renal impairment, hypoxic states, dehydration, or heavy alcohol intake. Sitagliptin has reported risks of pancreatitis, severe joint pain, hypersensitivity reactions, and bullous pemphigoid. Patients with a history of pancreatitis should use caution.

For background on the condition and treatment goals, see Type 2 Diabetes.

Dosage and Usage

Use Janumet only as directed by the prescriber and the official label. General patterns are consistent across regions:

• Immediate-release tablets are typically taken twice daily with meals.
• Extended-release tablets (sold as Janumet XR) are typically taken once daily with a meal, often in the evening.
• Prescribers often start metformin at a lower dose and titrate to improve GI tolerability.
• The total daily sitagliptin dose is commonly 100 mg in adults, given as the combination strength that matches the metformin dose.
• Do not split, crush, or chew extended-release tablets.

Starting dose and titration depend on current therapy, kidney function, and glycemic targets. When switching from separate sitagliptin and metformin tablets, the goal is to match previous individual doses. For a practical overview on titration and schedules, see Understanding Janumet Dosage.

Strengths and Forms

Availability may vary by supplier. Common presentations include:

• Immediate-release Janumet: 50 mg/500 mg, 50 mg/850 mg, 50 mg/1000 mg
• Extended-release Janumet XR: 50 mg/500 mg, 50 mg/1000 mg, 100 mg/1000 mg

Package sizes and tablet markings differ by strength. Your prescription will specify the exact combination and quantity.

Missed Dose and Timing

If a dose is missed, take it when remembered unless it is almost time for the next dose. If it is close to the next dose, skip the missed dose and take the next dose at the regular time. Do not double up to make up for a missed dose. Maintaining a consistent mealtime schedule helps limit GI side effects, especially during metformin titration.

Storage and Travel Basics

Store your tablets at room temperature in a dry place. Keep them in the original, tightly closed container to protect from moisture. Do not store in a bathroom or near heat sources. When traveling, carry your medicine in your hand luggage. Keep your prescription label with you for security checks. Pack an extra supply in case of delays. If crossing time zones, keep dosing tied to local mealtimes.

Benefits

Janumet offers convenience and clinical coverage across fasting and postprandial glucose. The combination reduces A1C for many adults when used with lifestyle measures. Metformin helps with basal glucose and insulin sensitivity. Sitagliptin targets meal-related spikes by enhancing incretin action. The combination is generally weight-neutral. The risk of hypoglycemia is low when not used with insulin or sulfonylureas.

For a plain-language overview of advantages and real-world considerations, read Benefits Of Janumet.

Side Effects and Safety

Common side effects include:

• Diarrhea, nausea, abdominal discomfort
• Gas or indigestion
• Headache
• Upper respiratory symptoms such as stuffy or runny nose
• Fatigue
• Metallic taste (less common)

Serious or rare risks include lactic acidosis with metformin, acute pancreatitis with sitagliptin, severe hypersensitivity reactions, kidney problems, bullous pemphigoid, and severe joint pain. Low vitamin B12 can occur with long-term metformin use. Hypoglycemia risk rises when Janumet is used with insulin or a sulfonylurea. Seek urgent care for severe abdominal pain, persistent vomiting, shortness of breath, unusual muscle pain, confusion, or rash with blistering.

More on tolerability and warning signs is discussed in Janumet XR Side Effects.

Drug Interactions and Cautions

Important interactions and cautions include:

• Alcohol: increases the risk of lactic acidosis with metformin.
• Insulin and sulfonylureas: increase hypoglycemia risk; clinicians may lower their doses.
• Carbonic anhydrase inhibitors (for example, topiramate): may raise acidosis risk.
• Cationic drugs eliminated by renal tubular secretion (for example, cimetidine): can increase metformin exposure.
• Digoxin: sitagliptin may increase digoxin levels; monitor if used together.
• Renal function: dosing depends on kidney status; severe impairment is a contraindication for metformin-containing products.
• Contrast studies: temporary interruption of metformin may be required around iodinated contrast.

Always provide a complete medication list, including over-the-counter drugs and supplements, to the prescriber.

What to Expect Over Time

Blood glucose may improve within days. A1C follows over weeks as metformin is titrated and meals are balanced. Gastrointestinal side effects often lessen after several days at a stable dose. Clinicians may adjust the strength to balance glucose targets and tolerability. Lab monitoring can include kidney function and vitamin B12 over time. Consistent use with meals and lifestyle measures supports the best results.

Compare With Alternatives

Therapy is individualized. Some patients use the extended-release formulation for once-daily dosing convenience. Others may use agents in the same or different classes when goals are not met or side effects occur.

Extended-release Janumet® XR delivers the same active medicines with a gradual metformin release and a once-daily schedule for many adults. Another DPP-4 plus metformin option is Jentadueto®, which combines linagliptin with metformin. Separate sitagliptin and metformin tablets are also used in some regimens. SGLT2 combinations may be considered when additional glucose or cardiorenal benefits are targeted. Choice depends on medical history, A1C goals, kidney function, and cost.

Pricing and Access

Canadian pricing can lower out-of-pocket costs for many patients. This platform lists strengths and transparent pricing with US delivery from Canada. Many shoppers compare the Janumet 50/1000 price across bottle sizes. Some also check the Janumet XR 50/1000 price when a once-daily option is preferred. Searches often include the Price of Janumet 50/1000 or the Janumet 50/1000 cost to plan monthly budgets.

Those comparing the Sitagliptin/Metformin 50/1000 price may also review the Sitagliptin/Metformin 50/1000 cost for different quantities. You can review the Janumet 500 mg/1000 mg price to see how the metformin strength affects the total. Many customers look for a Janumet 50/1000 online price from Canada. Others prefer to Buy Janumet 50/1000 from Canada for bulk refills with US shipping.

Savings language varies by payer status. Some patients track a Janumet 50/1000 cash price and may pay out of pocket. Others look for a Janumet 50/1000 price without insurance. We also see interest in a Janumet 50/1000 coupon or a Janumet XR 50/1000 coupon during seasonal promotions. For current offers, visit Promotions. Checkout is encrypted, and account tools help manage reorders.

Supply is shipped from Canada to the US after prescription verification. Pricing reflects Canadian sourcing and professional dispensing. Taxes, fees, and insurance reimbursement vary by plan and state. Contact support for payment methods accepted on the platform.

Availability and Substitutions

Availability can vary by strength, quantity, and supplier. If a preferred strength is not available, a prescriber may recommend a clinically appropriate alternative or a different strength with equivalent daily dosing. Substitutions depend on medical history and local regulations. This page will reflect available strengths, but it cannot predict restock dates.

Patient Suitability and Cost Saving Tips

Janumet may suit adults whose A1C remains above goal on metformin alone or who benefit from combination therapy. It is not suitable for those with severe renal impairment or metabolic acidosis. Caution applies with a history of pancreatitis or hypersensitivity to sitagliptin or metformin.

• Ask about multi-month fills to reduce per-bottle costs and simplify refills.
• Consider the XR formulation if once-daily dosing helps with adherence.
• Use reminders or organizers to keep doses aligned with meals.
• Keep a current medication list to avoid interactions that may affect safety or cost.
• Set refill reminders in your account to prevent gaps in therapy.

Questions to Ask Your Clinician

• Is immediate-release or extended-release better for my schedule and GI tolerance?
• What A1C and fasting glucose targets are appropriate for my health profile?
• How should kidney function be monitored with this combination?
• What symptoms should prompt urgent evaluation for lactic acidosis or pancreatitis?
• Can my insulin or sulfonylurea dose be reduced to lower hypoglycemia risk?
• Which strength best aligns with my current sitagliptin and metformin doses?
• Are there nonpharmacologic steps that would enhance my results?

Authoritative Sources

• Merck Prescribing Information
• FDA DailyMed
• Health Canada DPD

Start your Janumet request today with US delivery from Canada.