Januvia 100 mg (sitagliptin) oral tablets

Januvia is a prescription oral medicine that contains sitagliptin to help improve blood glucose control in type 2 diabetes, alongside diet and activity. This page explains how Januvia 100 mg fits into treatment, what the tablet is, and what safety topics are typically reviewed. It also outlines how prescriptions are handled on CanadianInsulin, including US shipping from Canada for cash-pay access without insurance.

The sections below cover mechanism of action, who it’s intended for, dosing basics, storage, side effects, and interaction cautions. Links to related guides and browseable medication categories are included for additional context.

What Januvia 100 mg Is and How It Works

Januvia contains sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor (an enzyme-blocker that affects incretin hormones). By inhibiting DPP-4, this medicine increases incretin hormones (gut hormones that help regulate insulin) after meals. That can support glucose-dependent insulin release and reduce glucagon, which may help lower blood sugar. The effect is generally glucose-dependent, meaning it is linked to current glucose levels rather than forcing insulin release at all times.

CanadianInsulin reviews prescription documentation; licensed partner pharmacies dispense the medication.

This therapy may be used alone or combined with other diabetes medicines, depending on the prescriber’s plan. It is not insulin, and it is not a substitute for meal planning or physical activity. For a deeper explanation of indications and typical add-on use, see the guide on Januvia Uses.

Why it matters: Knowing the drug class helps interpret side effects and interaction cautions.

Who It’s For

This medicine is used for glycemic control in type 2 diabetes mellitus in adults, as part of a broader care plan. Background information on the condition is available in the Type 2 Diabetes hub and the Diabetes Overview hub. It is not indicated for type 1 diabetes and is not used to treat diabetic ketoacidosis (DKA).

At a high level, it should not be used by anyone with a serious hypersensitivity (severe allergy) to sitagliptin or product components. Caution may be needed in people with kidney impairment, a history of pancreatitis (inflamed pancreas), or those who use other glucose-lowering medicines that can cause hypoglycemia (low blood sugar). Pregnancy, breastfeeding, and pediatric use require prescriber review because labeling and evidence may differ by population and jurisdiction.

Dosage and Usage

Januvia is taken by mouth as an oral tablet, commonly on a once-daily schedule. The usual adult regimen for many patients is Januvia 100 mg once daily, but the prescribed dose can differ based on kidney function and other clinical factors. Tablets may be taken with or without food, and many people choose a consistent time of day to support adherence. If a dose is missed, labeling typically recommends taking it when remembered unless it is close to the next scheduled dose.

Dosing details can vary by country labeling and individual clinical circumstances, so instructions on the prescription label should be followed. For a plain-language walkthrough of typical schedules and considerations, see Januvia Dosage.

Kidney function and dose selection

Sitagliptin is cleared largely through the kidneys, so renal function is an important factor in dose selection. Prescribers often use estimated glomerular filtration rate (eGFR) or creatinine clearance to decide whether a lower dose is needed. In practice, this is why the product is available in multiple strengths. Dose changes should not be made without clinician input, because underdosing can reduce glucose-lowering benefit and overdosing can raise side effect risk. If recent kidney labs are not available, a prescriber may order testing before choosing the most appropriate strength.

When it is combined with insulin or a sulfonylurea, clinicians may review the overall regimen to reduce hypoglycemia risk. Any change to the broader diabetes plan is typically based on glucose trends and tolerability rather than a single reading.

Strengths and Forms

Januvia is supplied as oral tablets in several strengths. The active ingredient is sitagliptin, commonly present as sitagliptin phosphate (a salt form used to make a stable tablet). Patients may see the ingredient described as sitagliptin phosphate 100 mg tablet on labels or pharmacy records, depending on local naming conventions.

Many searches refer to a januvia 100 mg tablet, januvia tab 100mg, or a januvia 100 mg pill; these usually describe the same oral dosage form but do not replace the prescription label. Availability of strengths, pack sizes, and brand versus generic for januvia 100mg can vary by pharmacy supply and jurisdiction.

Storage and Travel Basics

Tablets are typically stored at controlled room temperature in a dry place, protected from heat and moisture. Keep medication in its original container until use when possible, and avoid storing it in humid environments like bathrooms. If a tablet appears damaged, discolored, or crumbling, a pharmacist can advise whether it should be replaced.

When required, prescription details are confirmed with the prescriber before dispensing.

For travel, carrying the tablets in hand luggage can reduce exposure to temperature extremes and lost baggage. Keep the pharmacy label or a copy of the prescription available for identification during transit. If other medicines are being carried (for example, insulin or GLP-1 agents), confirm storage needs for each product because requirements differ.

Quick tip: Use a weekly pill organizer only if it stays dry.

Side Effects and Safety

As with most medicines, side effects can occur. Commonly reported effects with sitagliptin include upper respiratory symptoms (such as a runny nose or sore throat) and headache. Some people have mild gastrointestinal symptoms. Side effects can be harder to interpret when multiple diabetes medicines are used together, so documenting timing and symptom patterns can help a clinician assess causality.

Serious risks are less common but important. Januvia 100 mg has labeling warnings about pancreatitis (inflamed pancreas), severe hypersensitivity reactions (including anaphylaxis and angioedema, swelling under the skin), and severe joint pain that may be disabling. A blistering skin condition called bullous pemphigoid has also been reported with DPP-4 inhibitors. Hypoglycemia is more likely when this medicine is combined with insulin or sulfonylureas. For practical discussion of symptom patterns and when to seek urgent evaluation, see Navigating Januvia Side Effects.

Drug Interactions and Cautions

Drug interactions with sitagliptin are relatively limited, but they matter most when they change glucose levels or increase side effect risk. Using this therapy with insulin or sulfonylureas can raise the likelihood of hypoglycemia, so prescribers often reassess the full regimen. It is generally not combined with another DPP-4 inhibitor because that duplicates the same mechanism without a clear benefit.

Some medicines may slightly alter sitagliptin exposure, and sitagliptin can affect digoxin concentrations in certain situations; medication lists should include prescriptions, over-the-counter drugs, and supplements. People comparing options within the class may find it helpful to review mechanism and renal considerations in Linagliptin Vs Sitagliptin. Any medication change should be reviewed with the prescriber and pharmacist to account for kidney function, comorbidities, and the overall diabetes plan.

Compare With Alternatives

DPP-4 inhibitors are one option among several non-insulin medication classes used in type 2 diabetes. Alternatives within the same class include linagliptin, saxagliptin, and alogliptin, which have different dosing considerations (notably renal adjustment for some agents). Other commonly used classes include metformin, SGLT2 inhibitors, and GLP-1 receptor agonists; selection depends on clinical goals, kidney function, cardiovascular history, tolerability, and other individual factors.

In comparisons, Januvia 100 mg is often discussed alongside linagliptin because linagliptin dosing may be less dependent on kidney function. For related content, see Tradjenta Vs Januvia. A combination option is sitagliptin plus metformin (for example, extended-release combinations), which may reduce pill burden for some regimens; see Januvia Vs Janumet. Product pages for reference include Tradjenta Tablets and Janumet XR.

For browsing related lists rather than individual products, see the DPP 4 Inhibitors category.

Pricing and Access

Out-of-pocket pricing for diabetes medicines can vary widely by pharmacy, location, and supply channel. Common search terms such as januvia 100 mg price in usa, cost of januvia 100 mg at walmart, or goodrx januvia 100 mg reflect how often people compare estimates across tools and retailers. Listings such as januvia 100 mg amazon may not represent a dispensed prescription supply, and legitimacy checks matter for prescription-only therapy.

For Januvia 100 mg, the cash price can also differ based on strength, quantity, and whether a brand or generic sitagliptin is dispensed. CanadianInsulin supports access on a cash-pay basis for people not using insurance.

To explore other options in the same therapeutic area, browse Non Insulin Medications. Site-wide offers, when available, are listed on Current Promotions. Prescription requirements and documentation steps can vary by product and destination, so orders may require additional confirmation before dispensing.

Authoritative Sources

The links below provide official or clinically reviewed references for sitagliptin and the branded product labeling. These sources are useful when reviewing contraindications, warnings, and population-specific use.

• For the approved U.S. labeling and application details, see FDA Drugs@FDA: Januvia (sitagliptin).
• For an evidence-based consumer summary, see MedlinePlus: Sitagliptin.

These references do not replace individualized clinical guidance. A pharmacist or prescriber can interpret labeling in the context of kidney function, other medicines, and glucose goals.

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This content is for informational purposes only and is not a substitute for professional medical advice.