Please note: a valid prescription is required for all prescription medication.
What Crestor® Is and How It Works
Crestor® (rosuvastatin calcium) is a statin used to reduce LDL cholesterol and triglycerides and to increase HDL. It is prescribed for primary hyperlipidemia, mixed dyslipidemia, and to lower the risk of cardiovascular events in appropriate patients. Film‑coated tablets are taken by mouth once daily, with or without food, across strengths such as 5 mg, 10 mg, 20 mg, and 40 mg. Many customers compare Crestor price by strength when planning a supply. CanadianInsulin is a prescription referral service. Prescriptions are verified with your clinic, and orders are filled by licensed Canadian pharmacies.
Rosuvastatin inhibits HMG‑CoA reductase, the rate‑limiting enzyme in cholesterol biosynthesis. This reduces hepatic cholesterol synthesis, upregulates LDL receptors, and increases LDL clearance. Clinical studies show robust LDL lowering across doses, with greater effects at 20 mg and 40 mg. Lipid changes typically begin within 1–2 weeks and reach near‑maximal effect by 4 weeks. Crestor tablets are available in multiple dosage strengths, including common options such as Crestor 5mg, Crestor 10 mg tab, Crestor 20 mg tab, and Crestor 40 mg tablet.
Dosage and Usage
- Starting dose: often 10–20 mg once daily. Some patients start at 5 mg (for example, those with increased exposure risk or when used with certain interacting drugs). Maximum dose is 40 mg, reserved for patients who have not achieved LDL goals on 20 mg and are at high cardiovascular risk.
- Administration: take at the same time each day, with or without food. Swallow tablets whole. Consistent daily use supports steady lipid control.
- Titration: assess lipids after 2–4 weeks. Adjust the dose at intervals of 4 weeks or more to meet LDL targets.
- Special populations: lower starting doses may be appropriate in severe renal impairment, in those with certain drug interactions, or in populations with increased rosuvastatin exposure.
- Drug interactions: avoid combining with cyclosporine. Use caution with gemfibrozil or other fibrates, niacin, and certain protease inhibitors. Discuss alternatives if interacting therapy is needed.
- Antacids: aluminum/magnesium antacids can reduce rosuvastatin levels. If needed, take Crestor at least 2 hours before antacids.
- Missed dose: take when remembered unless the next dose is near. Do not double doses.
- Monitoring: check lipid panel at baseline and 2–4 weeks after starting or changing the dose. Liver enzymes and creatine kinase may be checked if clinically indicated.
- Storage: store tablets at 20–25°C (68–77°F); excursions 15–30°C (59–86°F). Keep in the original, tightly closed container to protect from moisture.
- Home handling: keep tablets dry and away from bathroom humidity. Do not use if tablets are discolored or damaged.
- Travel: carry your medication in a labeled container in your carry‑on. Avoid leaving tablets in a hot car or near freezing temperatures.
- Refills: reorder early to prevent gaps. Multi‑month supplies can reduce trips and help adherence.
Benefits and Savings
Rosuvastatin is a high‑potency statin that reduces LDL cholesterol and triglycerides and increases HDL. It supports cardiovascular risk reduction when used with diet and lifestyle changes. Once‑daily dosing and several tablet strengths make therapy convenient. Many customers save 60–80% vs typical U.S. prices. See our promotions page for current offers, including any Crestor coupon if available.
Orders are sourced through licensed, vetted partner pharmacies. Medications are authentic brands with a broad selection and value‑focused pricing.
Side Effects and Safety
- Common: headache, myalgia (muscle pain), weakness, abdominal pain, nausea, diarrhea.
- Less common: constipation, dizziness, rash, joint pain, sleep disturbance.
- Lab changes: mild increases in liver enzymes or creatine kinase may occur.
Serious but rare effects include myopathy/rhabdomyolysis and liver injury. Risk is higher at 40 mg, in older adults, with hypothyroidism, renal impairment, heavy alcohol use, or interacting drugs. Stop therapy and seek medical care for unexplained muscle pain, weakness, or dark urine. Contraindicated in pregnancy and during breastfeeding, and in active liver disease. Rosuvastatin can raise blood glucose in some patients. Warfarin effects may increase; INR monitoring may need adjustment. Separate dosing from aluminum/magnesium antacids as noted above.
Onset Time
Lipid changes start within 1–2 weeks of consistent daily use. Most LDL reduction appears by 4 weeks after each dose adjustment. Triglyceride improvements may take 2–4 weeks, depending on baseline levels and adherence. Cardiovascular risk reduction accrues over months and years of maintained lipid control and comprehensive risk management.
Compare With Alternatives
Rosuvastatin is one of the most potent statins. Generic Rosuvastatin contains the same active ingredient as Crestor and is bioequivalent, making it a value‑oriented choice for many patients. Strengths such as rosuvastatin calcium 10 mg and rosuvastatin calcium 20 mg are commonly used to meet LDL goals.
Lipitor® (atorvastatin) is another widely used statin. Atorvastatin 40–80 mg and rosuvastatin 20–40 mg are both considered high‑intensity options. Choice can depend on prior response, tolerability, drug interactions, and lipid targets. Patients with persistent mixed dyslipidemia may respond differently to these agents; clinicians tailor therapy based on individual profiles.
Combination Therapy
- Statin plus ezetimibe: often used when additional LDL lowering is needed beyond statin alone.
- Statin plus omega‑3 fatty acids: considered for persistent hypertriglyceridemia after lifestyle measures.
- Statin with antihypertensives: agents like ACE inhibitors support overall cardiovascular risk reduction.
- Use caution with fibrates or high‑dose niacin due to increased myopathy risk; combinations require clinical supervision.
Patient Suitability and Cost‑Saving Tips
Candidates include adults with primary hyperlipidemia or mixed dyslipidemia, heterozygous familial hypercholesterolemia, and patients needing risk reduction after cardiovascular assessment. Rosuvastatin is not suitable during pregnancy or breastfeeding, or with active liver disease. Dose adjustments may be considered in severe renal impairment and when interacting medicines are necessary.
Cost‑saving approaches can include selecting the generic rosuvastatin when appropriate, choosing a multi‑month supply, and coordinating prescription renewals to avoid urgent local fills. Ordering earlier than the last tablet helps maintain continuity. Proper storage prevents waste from moisture damage.
Authoritative Sources
Crestor consumer information (AstraZeneca)
Health Canada Drug Product Database: rosuvastatin/CRESTOR listings
FDA: CRESTOR (rosuvastatin calcium) prescribing information
Order Crestor® from CanadianInsulin: add to cart, upload your prescription, and we ship with prompt, express, cold‑chain handling.
This page is educational and not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional about medications and health conditions.
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What is Crestor used for?
Crestor (rosuvastatin) is a statin for lowering LDL cholesterol and triglycerides and raising HDL. It treats primary hyperlipidemia and mixed dyslipidemia, and reduces cardiovascular risk in appropriate patients when combined with diet and lifestyle measures as directed by a healthcare professional.
How do I take Crestor tablets?
Crestor is taken by mouth once daily, with or without food, at the same time each day. Doses commonly start at 10–20 mg, with a range of 5–40 mg. Lipids are reassessed in 2–4 weeks and the dose adjusted as needed by a clinician to meet LDL goals.
What strengths of Crestor are available?
Film‑coated tablets are available in multiple strengths, including 5 mg, 10 mg, 20 mg, and 40 mg. Prescribers select a dose based on lipid levels, cardiovascular risk, and tolerability. The 40 mg dose is reserved for patients not at goal on 20 mg who remain at high risk.
How long until Crestor starts working?
LDL reductions usually begin within 1–2 weeks of consistent daily use. Most of the effect appears about 4 weeks after starting or after each dose change. Ongoing risk reduction depends on maintaining lipid control and addressing other cardiovascular risk factors over time.
What side effects are associated with Crestor?
Common effects include muscle pain, headache, abdominal pain, nausea, and weakness. Rare but serious risks are myopathy/rhabdomyolysis and liver injury. Risk increases with higher doses, advanced age, interacting drugs, hypothyroidism, or heavy alcohol use. Seek prompt care for unexplained muscle pain, weakness, or dark urine.
Are there important drug or food interactions?
Avoid use with cyclosporine. Use caution with gemfibrozil, other fibrates, niacin, and some protease inhibitors. Warfarin effects can increase. Aluminum/magnesium antacids can lower rosuvastatin levels; separate doses by at least two hours. No specific food restrictions are required, but alcohol intake should be limited.
Can I check Crestor price and save when ordering?
Customers can view Crestor price during checkout at CanadianInsulin. Many save 60–80% compared with typical U.S. prices, and multi‑month supplies can reduce per‑fill costs. See the promotions page for current offers. Orders ship with prompt, express, cold‑chain handling after prescription verification.
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