Please note: a valid prescription is required for all prescription medication.
These NPH insulin vials help control blood sugar for people with diabetes. This page explains how the medicine works, safe use, storage, and ordering steps, including Ships from Canada to US options for those paying without insurance. You will also find alternatives and guidance on access.
What Humulin N Is and How It Works
Humulin N® is human insulin isophane suspension (NPH) used for basal glucose control in adults and children with diabetes. It lowers blood sugar by enhancing peripheral uptake and by limiting hepatic glucose production. Each Insulin NPH (isophane) vial contains a cloudy suspension intended for subcutaneous use. CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.
As an intermediate-acting basal agent, this therapy typically covers between meals and overnight. It can be used alone or with a rapid- or short-acting insulin as part of a basal-bolus plan. For condition background, see Diabetes. For fundamentals on this class, review Intermediate Acting Insulin.
Who It’s For
This medicine is indicated for improving glycemic control in adults and pediatric patients with diabetes mellitus, including type 1 and type 2. It is not appropriate for treating diabetic ketoacidosis; intravenous regular insulin is typically required in that setting. People with known hypersensitivity to insulin or excipients should not use it. Your clinician may exercise caution with renal or hepatic impairment. It is not for use in insulin pumps. Learn more about specific conditions at Type 1 Diabetes and Type 2 Diabetes.
Dosage and Usage
Use the Humulin N insulin NPH vial only as directed for subcutaneous injection. Do not administer intravenously or in an insulin pump. Gently roll the vial between your palms to resuspend the cloudy suspension before drawing up the dose. Inspect visually; do not use if clumps, particles, or frost appear.
Inject in the abdomen, thigh, buttock, or upper arm, rotating sites to lower the risk of skin changes. When your prescriber recommends mixing with regular insulin, draw the clear insulin into the syringe first, then the cloudy suspension, and inject promptly. Always match U-100 syringes with U-100 insulin. Avoid sharing needles or syringes. For device technique comparisons, see Insulin Pen Vs Syringe.
Strengths and Forms
Common presentations include vials and prefilled pens. Availability can vary by pharmacy and by timing. Your prescriber will specify the presentation and volume.
- Humulin N 100 unit/mL 10 mL vial
- Other options may include a 3 mL vial or a prefilled pen device, depending on market supply.
Explore similar options under Intermediate Acting Insulin Vials.
Missed Dose and Timing
If you miss a scheduled basal dose, check your blood glucose and follow your prescriber’s guidance. If it is close to your next dose, it may be safer to skip and resume the usual plan. Do not double doses. Monitor more frequently after a missed or late dose, carry glucose sources for symptoms, and review the FDA label or consult your healthcare professional for individualized advice.
Storage and Travel Basics
Keep unopened vials refrigerated and never freeze them. Protect from direct heat and sunlight. After first puncture, in-use vials may be kept at room temperature as allowed by the official label; confirm the permitted in-use period on the package insert. Store out of reach of children. During travel, use an insulated case with cool packs, but avoid direct contact between the vial and ice. Keep a backup supply and extra syringes. Carry documentation for airport screening. Our pharmacies use temperature-controlled handling when required.
Pen Handling and Sharps Disposal
This product is supplied as a vial for use with U-100 syringes. Resuspend by gently rolling the vial. Use a new sterile syringe and needle for each injection. Do not share. Place used needles and syringes in an FDA-cleared sharps container. If one is not available, use a heavy-duty plastic container with a tight lid and follow local rules for disposal. Do not throw loose needles into household trash or recycling.
Benefits
This basal therapy provides intermediate duration coverage between meals and overnight. It can be combined with mealtime insulin to align with many care plans. The suspension is designed to be resuspended before dosing, which can help make dose preparation more consistent. Many patients and prescribers value the ability to adjust timing within a structured daily schedule when clinically appropriate.
Side Effects and Safety
- Low blood sugar: sweating, shakiness, confusion
- Injection site redness or irritation
- Skin thickening or dents at sites
- Weight gain
- Fluid retention or swelling
- Itching or mild rash
- Allergic reaction signs
Serious risks can include severe hypoglycemia and low potassium. Thiazolidinediones used with insulin may cause fluid retention and can worsen heart failure in susceptible patients. Always carry a source of fast-acting carbohydrate. Seek urgent care for severe reactions, persistent low glucose, or signs of anaphylaxis.
Drug Interactions and Cautions
Several medicines and substances can affect glucose control or mask symptoms. Examples include beta blockers (may mask hypoglycemia), corticosteroids and some diuretics (may increase glucose), and alcohol (may raise or lower glucose). Certain hormonal therapies and sympathomimetic agents can alter requirements. Review all prescription, OTC, and herbal products with your prescriber. Adjustments, if needed, should be clinician-directed. Use caution with illness, changes in activity, or meal pattern shifts.
What to Expect Over Time
With steady scheduling and monitoring, basal glucose patterns may become more predictable. Your clinician may adjust timing or dose based on logs, meter or CGM data, and A1C. Keep a record of injections, meals, activity, and symptoms. Maintain consistent carbohydrate intake as advised by your care team. Contact your prescriber if you observe frequent highs or lows, or if your routine changes significantly.
Compare With Alternatives
Some patients use an alternative NPH product such as NPH Vials. Others prefer a prefilled device like the Kwikpen for dose convenience. Short-acting options are often paired for meals when clinically appropriate. Your prescriber can help determine the best combination for your plan.
Pricing and Access
Transparent quotes reflect Canadian pricing with US delivery from Canada. After your prescription is confirmed, you can view the Humulin N vial price and choose quantities that fit your plan. Checkout is encrypted. If you are comparing options or seasonal offers, see Bulk Savings and current Promotions. Your order is prepared by licensed pharmacies after prescription verification.
Availability and Substitutions
Supply can vary. If a chosen presentation is unavailable, your prescriber may recommend a clinically appropriate substitute. Some markets also offer a Humulin N 3 mL vial; availability may change over time. Your pharmacist or clinician can help determine an equivalent presentation or an alternative insulin within the same class when medically suitable.
Patient Suitability and Cost-Saving Tips
This treatment may suit people needing intermediate basal coverage who can monitor glucose regularly and follow an injection schedule. It may not suit those with frequent severe hypoglycemia or who require continuous pump therapy. To reduce costs, consider multi-month fills when appropriate, coordinate refills before travel, and use reminders to avoid urgent local purchases. You can Order Humulin N vial online after prescription verification, then align refill timing with your monitoring supplies. Combining items in one shipment can reduce per-order fees.
Questions to Ask Your Clinician
- Starting plan: once or twice daily, and typical timing?
- Mixing rules with regular insulin and technique reminders?
- Site rotation plan to reduce skin changes?
- How to adjust during illness or travel?
- Hypoglycemia prevention and glucagon instructions?
- When to review logs and labs for adjustments?
- What signs require urgent medical attention?
Authoritative Sources
| Resource | Link |
|---|---|
| FDA DailyMed | HUMULIN N label |
| Manufacturer | Eli Lilly Humulin |
| Health Canada DPD | Humulin N product |
Ready to proceed with CanadianInsulin? Request a quote and place your order with express service and US delivery from Canada. This information is not a substitute for medical advice; always consult your healthcare professional.
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Can this insulin be mixed with regular insulin?
Your prescriber may instruct you to mix this suspension with regular insulin for meal coverage. If mixing is advised, the clear regular insulin is typically drawn into the syringe first, followed by the cloudy suspension. Roll the vial to resuspend before drawing. Inject promptly after preparing the mixture. Do not mix with insulin analogs unless your clinician specifically instructs you to do so. Always follow the product label and your care team’s guidance.
How should I time doses relative to meals and activity?
This basal insulin is usually given once or twice daily at consistent times, independent of meals. Mealtime coverage, if needed, is provided by a separate rapid- or short-acting insulin. Keep timing consistent day to day and monitor glucose regularly. Record readings, meals, and activity to support safe adjustments. Your clinician will tailor the schedule to your needs based on logs and lab results.
Can I use this product with an insulin pump?
No. NPH insulin suspensions are not indicated for continuous subcutaneous insulin infusion pumps. Pumps typically use rapid-acting analogs. This vial is intended for subcutaneous injections with U-100 syringes. If you are considering a change in delivery method, discuss options with your clinician and review the official label for approved uses and device compatibility.
What if the suspension looks different than usual?
Before drawing a dose, roll the vial gently to fully resuspend the contents. The suspension should look uniformly cloudy after mixing. Do not use the vial if you see clumps, particles, clear layers, or frozen material. Dispose of compromised vials safely and start a new one. If in doubt, contact your pharmacist or prescriber and review the label’s visual inspection guidance.
How should I store in-use and unopened vials?
Unopened vials should be refrigerated and never frozen. Protect from heat and direct light. After first use, many labels allow room-temperature storage for a limited period; check the package insert for the exact in-use timeframe. Do not expose the vial to excessive heat or cold. Keep out of reach of children. When traveling, use an insulated case and keep insulin in your carry-on bag.
What are the most common side effects to watch for?
Low blood sugar is the most common reaction. Watch for shakiness, sweating, fast heartbeat, hunger, or confusion. Injection site redness or skin changes can occur. Weight gain and mild fluid retention are also reported. Severe hypoglycemia, allergic reactions, or signs of low potassium require urgent evaluation. Review warning signs with your clinician and carry a source of fast-acting carbohydrate.
How do I dispose of needles and syringes safely?
Place used needles and syringes immediately into an FDA-cleared sharps container. If one is not available, use a heavy-duty plastic container with a tight screw-top lid. Follow local or state rules for disposal. Do not throw loose needles in household trash or recycling. Keep containers out of reach of children and pets, and replace them before they become overfilled.
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