Avalide® Tablets for Hypertension

This prescription combines irbesartan and hydrochlorothiazide to help manage hypertension. You can review options, strengths, storage, and how to order, with US delivery from Canada. It also outlines ways to pay without insurance and receive safe delivery.

What Avalide Is and How It Works

Avalide® combines two medicines: irbesartan, an angiotensin II receptor blocker, and hydrochlorothiazide, a thiazide diuretic. Together, they help lower blood pressure through complementary actions.

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Irbesartan blocks the effects of angiotensin II at the AT1 receptor, which can relax blood vessels. Hydrochlorothiazide increases sodium and water excretion, which may reduce fluid volume. Irbesartan HCTZ tablets are used when a single agent may not provide adequate control. The combination can be taken long term under medical supervision.

Who It’s For

This combination is indicated for adults with high blood pressure who may benefit from dual therapy. It is often selected after an individual agent does not reach goals, or when a prescriber prefers a single tablet containing two classes. People with a history of sulfonamide allergy, anuria, or significant electrolyte disturbances should avoid this therapy. It is not recommended during pregnancy and is generally avoided while breastfeeding.

If you are exploring class options, see our High Blood Pressure collection and broader Hypertension Cardiovascular category for related therapies.

Some patients with coexisting kidney issues may require closer monitoring. For condition background and related medicines, visit Kidney Disease.

Generic Avalide tablets are available and may provide a cost-conscious option when appropriate.

Dosage and Usage

Take this medicine once daily, as directed on your prescription label. You may take it with or without food. Swallow the tablet with water and try to take it at the same time each day. Your prescriber may adjust the dose based on blood pressure response and tolerability. Do not change how you take it without checking the official label or speaking with a healthcare professional.

Consistent use is important. If you experience dizziness after starting or changing doses, rise slowly from sitting or lying positions. Report persistent or severe symptoms to your prescriber.

Strengths and Forms

This treatment is supplied as oral tablets in multiple strengths. Availability can vary by manufacturer and pharmacy.

• 150 mg/12.5 mg tablets
• 300 mg/12.5 mg tablets
• 300 mg/25 mg tablets

Your prescriber selects a strength based on prior therapy, blood pressure targets, and clinical factors.

Missed Dose and Timing

If you miss a dose, take it when remembered the same day. If it is close to your next scheduled time, skip the missed tablet and resume your usual schedule. Do not take two doses at once. If frequent misses occur, discuss adherence strategies with your prescriber.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from excessive heat and light. Keep the medication in its original container with the label intact. Always keep out of reach of children and pets. Do not use tablets that are damaged or show unusual discoloration.

When traveling, pack your medicine in carry-on baggage. Bring a copy of your prescription or a photo of the label. Keep doses in a secure, clean container and plan for time zone changes to avoid missed doses. If you are driving long distances, carry water and avoid dehydration.

Benefits

This medicine delivers two mechanisms in one tablet, which may simplify regimens. The combination can help reduce clinic and home blood pressure readings when monotherapy is not sufficient. Once-daily dosing supports routine use. A range of strengths provides flexibility for titration by a prescriber.

Side Effects and Safety

• Dizziness or lightheadedness
• Headache or fatigue
• Increased urination
• Nausea or stomach discomfort
• Photosensitivity or rash

Potentially serious effects can include low blood pressure, kidney function changes, or significant electrolyte abnormalities (such as low sodium or potassium). Rarely, allergic reactions or angioedema can occur. Thiazides have been associated with acute myopia and secondary angle-closure glaucoma; report sudden visual changes. Contact a clinician urgently if you notice facial swelling, trouble breathing, severe weakness, or vision symptoms.

Drug Interactions and Cautions

Tell your prescriber about all medicines, vitamins, and supplements you use. Notable interactions may include:

• Lithium, due to increased risk of toxicity
• NSAIDs, which can reduce antihypertensive effect and affect kidney function
• Other blood pressure agents or alcohol, which may enhance hypotension
• Potassium supplements or potassium-sparing diuretics, which can raise potassium levels
• Bile acid sequestrants (such as cholestyramine), which may reduce diuretic absorption
• Aliskiren, generally avoided with ARBs in diabetes

Use caution with kidney or liver impairment. Monitor electrolytes and renal function as directed. Learn more about protecting kidney health in our article Kerendia Uses.

What to Expect Over Time

Blood pressure typically changes gradually with steady use. Your prescriber may request home readings or office checks to guide therapy. Some people notice dizziness early in treatment or after dose changes, which often improves with time and hydration. Long-term control usually requires consistent daily dosing, routine monitoring of electrolytes and kidney function, and attention to diet and salt intake.

Compare With Alternatives

Other ARB-based options include single-agent ARBs or ARB/diuretic combinations. Telmisartan with hydrochlorothiazide, available as Micardis Plus, offers a similar two-class approach with different components. Losartan, available as Cozaar, is an ARB that may be paired with a diuretic when needed. Choice depends on clinical history, tolerance, laboratory results, and prescriber preference.

Pricing and Access

We list Irbesartan/HCTZ price transparently so you can compare strengths and manufacturers. Many patients use self-pay when insurance coverage is limited, and others pay out of pocket for convenience. Our team displays Avalide price alongside the generic so you can review options without contacting support. We provide US shipping from Canada and clear checkout steps. For occasional savings, see current Promotions. Your payment is processed through encrypted checkout for added security.

For broader options across drug classes, browse Heart Health Medications.

Availability and Substitutions

Supply can vary by manufacturer and strength. If a specific tablet is temporarily unavailable, your prescriber may recommend an appropriate alternative in the same class or a different class. Pharmacy-level generic substitution follows prescription instructions and local regulations. We do not publish restock dates.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who require two agents to control blood pressure and can maintain daily dosing. It may not suit those with anuria, significant sulfonamide allergy, pregnancy, or recurrent gout. Patients with kidney or liver concerns require monitoring.

To manage Irbesartan HCTZ cost, consider multi-month supplies when appropriate, which can reduce per-fill fees. Set reminders for refills to avoid gaps in therapy. Ask your prescriber if generic versions are suitable for you. Keeping lab appointments and reporting side effects early can also prevent unnecessary switches or urgent visits.

Questions to Ask Your Clinician

• Is this combination appropriate based on my previous response to single agents?
• How should I monitor my blood pressure at home?
• Which lab tests and how often should they be checked?
• What symptoms would require contacting the office promptly?
• Are there diet or salt recommendations specific to this therapy?
• Could other medicines I take interact with this prescription?
• What are the plans if my readings remain above target?

Authoritative Sources

• DailyMed: Irbesartan and Hydrochlorothiazide Tablets
• Health Canada Drug Product Database

Order Irbesartan HCTZ online. Ships from Canada to US with prompt, express, temperature-controlled handling when required. Always follow your prescription instructions.

This page is informational and does not replace professional medical advice. Use only as prescribed by a licensed clinician.