Irbesartan HTC (Irbesartan/Hydrochlorothiazide)

Irbesartan HTC is a prescription combination tablet used to treat hypertension (high blood pressure). This page summarizes typical strengths, dosage basics, key safety points, and storage so you can review essentials before using our referral service, including options for people without insurance. Ships from Canada to US.

What Irbesartan HTC Is and How It Works

Prescriptions are verified with the prescriber when required.

This medicine combines two antihypertensive agents in one oral tablet: irbesartan and hydrochlorothiazide. Irbesartan is an angiotensin II receptor blocker (ARB), which reduces the hormone-driven tightening of blood vessels. Hydrochlorothiazide is a thiazide diuretic (water pill) that increases salt and water excretion through the kidneys. The combination is commonly referred to as irbesartan hydrochlorothiazide tablets, and it is often described as an Avalide generic or Avalide equivalent in markets where that brand exists.

By lowering vessel resistance and reducing fluid volume, the combination can lower blood pressure more than either ingredient alone for some patients. This can be relevant when a single agent has not adequately controlled readings, or when a prescriber wants a simplified regimen. Like other ARB/diuretic combinations, it does not cure hypertension; it manages it over time when taken as directed and monitored appropriately.

Who It’s For

Irbesartan HTC is generally used for adults with high blood pressure, particularly when combination therapy is considered appropriate by a prescriber. It may be used after a trial of one medication has not achieved target control, or when a clinician determines that starting with a combination is suitable. For broader context on the condition and typical treatment approaches, the Hypertension Hub is a browseable list of related therapies and resources.

Contraindications and “do not use” situations depend on the official labeling and a patient’s history. In general, ARB/thiazide combinations are not used in pregnancy because drugs acting on the renin-angiotensin system can harm the fetus. Hydrochlorothiazide is also not used in anuria (when the kidneys do not produce urine). Caution is commonly needed with kidney impairment, dehydration, electrolyte disorders, liver disease, gout, or diabetes. A healthcare professional should also review any prior allergic reactions to similar medications.

Dosage and Usage

Most labeling for Irbesartan HTC describes once-daily dosing. Tablets are typically taken at the same time each day and can be taken with or without food. Because hydrochlorothiazide can increase urination, some people prefer a morning schedule; however, timing should follow the prescriber’s directions. If a dose is missed, standard instructions for many daily medicines are to take it when remembered unless it is close to the next dose; doubling up is generally avoided unless a clinician instructs otherwise.

Commonly available dose combinations include 150/12.5 mg, 300/12.5 mg, and 300/25 mg (irbesartan/hydrochlorothiazide). A prescriber may adjust based on blood pressure response, kidney function, and electrolytes, and may also consider whether the person is taking other diuretics or antihypertensives. Patients with diabetes and hypertension may benefit from structured monitoring plans; the article Managing Diabetes And Hypertension offers general education about coordinated care.

Why it matters: Consistent timing supports steadier blood-pressure control and fewer missed doses.

Strengths and Forms

Irbesartan HTC is supplied as oral tablets containing a fixed-dose combination of irbesartan and hydrochlorothiazide. The strengths available can vary by market and pharmacy sourcing, and not every dose combination is stocked at all times. In some care plans, a clinician may use separate components (such as irbesartan tablets 150 mg or irbesartan tablets 300 mg) to tailor doses before switching to a fixed combination.

The strengths most commonly referenced for irbesartan HCTZ tablets include the following options:

Storage and Travel Basics

Store tablets at room temperature, protected from moisture and excess heat. Keep the medication in its original container until use, and close the lid tightly after each dose. Avoid storing in bathrooms or places with frequent humidity changes. If a tablet looks degraded (crumbling, discoloration, or unusual odor), it should not be used and a pharmacist should be consulted about replacement.

For travel, carry medication in hand luggage when possible and keep a current medication list available. Time-zone changes can complicate daily schedules; a pharmacist can explain practical, non-medical strategies for maintaining routine. If you want more general reading on cardiovascular medications and care topics, Cardiovascular Articles is a browseable collection of guides.

Quick tip: Keep tablets in labeled packaging to reduce airport screening issues.

Side Effects and Safety

When starting Irbesartan HTC, common effects can include dizziness, lightheadedness (especially when standing), fatigue, and increased urination. Because hydrochlorothiazide can change electrolyte balance, some people may develop low potassium or low sodium, while irbesartan can increase potassium in others; routine bloodwork helps identify changes early. Kidney function can also shift, particularly in patients with underlying kidney disease, dehydration, or use of medicines that affect renal blood flow.

More serious reactions are less common but require prompt medical evaluation. These can include fainting from low blood pressure, angioedema (swelling of the face, lips, tongue, or throat), severe rash, significant reduction in urine output, or symptoms of severe electrolyte disturbances (confusion, marked weakness, palpitations). Hydrochlorothiazide has also been associated with photosensitivity and, rarely, acute angle-closure glaucoma (sudden eye pain or vision changes). Seek urgent care for severe symptoms, and report new or worsening issues to a prescriber.

Licensed Canadian pharmacies dispense medication after verification.

Drug Interactions and Cautions

Drug interactions can change safety or effectiveness, so a complete medication list is important. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen may reduce blood-pressure control and, in some cases, increase kidney risk when combined with ARBs and diuretics. Lithium levels can rise with some diuretics, and potassium supplements or salt substitutes may raise the risk of hyperkalemia (high potassium) when combined with irbesartan. Other blood-pressure medicines can add to the blood-pressure–lowering effect.

Additional cautions apply to alcohol (which can worsen dizziness), diabetes medications (blood sugar may change with thiazides), and corticosteroids or stimulant laxatives (which can contribute to electrolyte shifts). People with gout may have increased uric acid with thiazide diuretics. Before starting any new prescription, over-the-counter medicine, or supplement, a pharmacist or prescriber should screen for interactions and monitoring needs.

Quick tip: Keep an updated list of medicines and supplements in your account.

Compare With Alternatives

Clinicians choose among several medication classes to manage blood pressure. One approach is to use an ARB alone, then add a diuretic if needed. For example, a prescriber might consider Irbesartan Tablets if a single-agent regimen is appropriate. Another approach is a different ARB plus hydrochlorothiazide combination; some patients may be prescribed alternatives such as Candesartan HCTZ based on prior response, tolerability, or formulary decisions.

Other common alternatives include ACE inhibitors (a related class), calcium channel blockers, and different diuretics. Each class has distinct precautions and monitoring considerations. If you are comparing medication classes, these educational resources may help with general background: Bystolic Blood Pressure Guide and Atenolol Hypertension Guide.

Some people also have diabetes, kidney disease, or other cardiovascular risks that influence medication selection and follow-up. For broader lifestyle and risk-management context, Manage Heart Health provides general education that can be discussed with a clinician.

Pricing and Access

Costs for combination blood-pressure medicines vary by strength, quantity, and pharmacy dispensing fees. Generic options (including the combination often described as an Avalide generic) may have different cash-pay totals than brand products. If you are seeking Irbesartan HTC access through CanadianInsulin, your request is routed through a prescription referral process, and documentation requirements can depend on the medication and destination rules.

This service offers cash-pay access to prescription medication.

For people without insurance, it can be helpful to compare available strengths and confirm the quantity on the prescription before checkout. Limited-time programs may change; a single place to review site-wide updates is Prescription Program Details. For condition-focused browsing, the Cardiovascular Category lists related therapies and supplies that may be relevant to a prescriber’s plan.

Authoritative Sources

For the most reliable details on indications, contraindications, and monitoring, consult the official product labeling and a pharmacist. Education articles can provide helpful context, but they do not replace approved prescribing information. If you are reviewing related drug classes, these background reads may be useful discussion starters with a healthcare professional: Altace Heart Health and Benazepril And Kidneys.

For U.S. labeling details, consult the DailyMed irbesartan/hydrochlorothiazide listings. For general public-health guidance on high blood pressure, see CDC high blood pressure information.

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This content is for informational purposes only and is not a substitute for professional medical advice.