Prascend® Tablets for Horses

Prascend® (pergolide mesylate) tablets are the veterinary standard for managing pituitary pars intermedia dysfunction in horses. This page helps you compare Prascend price options with Canadian pricing and US delivery from Canada. You can buy Prascend for horses from Canada with prompt, express shipping, and see costs upfront even without insurance.

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What Prascend® Is and How It Works

Prascend® is a once-daily pergolide tablet from Boehringer Ingelheim for horses diagnosed with pituitary pars intermedia dysfunction (PPID), often called equine Cushing’s disease. CanadianInsulin ships from Canada to the US, so owners can access Canadian pricing with US shipping.

PPID involves overactivity of the pars intermedia in the pituitary gland. This leads to increased hormones, including ACTH, which drive the clinical signs of PPID. Pergolide is a dopamine receptor agonist that replaces the horse’s reduced dopamine signaling. By stimulating pituitary dopamine receptors, pergolide decreases abnormal hormone output and helps control the clinical signs associated with PPID.

Who Prascend® Is For

Prascend is indicated for the management of PPID in horses. It is intended for use under the guidance of a veterinarian. Horses with confirmed or strongly suspected PPID may benefit from therapy to reduce disease-related signs such as haircoat abnormalities, lethargy, changes in drinking and urination, and body condition changes.

Prascend should be used with caution in horses with significant underlying systemic disease. Safety in breeding, pregnant, or lactating mares has not been established. Do not use in horses with known hypersensitivity to pergolide. Horses treated with Prascend are not for human consumption.

Dosage and Usage

Prascend is given by mouth once daily. The tablet is scored to help achieve the prescribed dose. The labeled starting dose is 2 micrograms per kilogram of body weight once daily. For a 500 kg horse, that starting dose equals one 1 mg tablet daily. Veterinarians may adjust the dose in small increments based on clinical response and monitoring. The maximum labeled dose is 10 micrograms per kilogram once daily. If the horse is sensitive at initiation, a veterinarian may choose a lower starting amount and titrate upward.

Tablets can be administered alone or with a small amount of feed to ensure the full dose is consumed. Consistent daily timing supports steady control. Monitoring typically includes clinical observation and periodic endocrine testing as advised by the veterinarian. Always follow the current package insert and your veterinarian’s instructions.

Strengths and Forms

Prascend is available as:

• 1 mg scored tablets
• Common package sizes include 60 tablets and 160 tablets

Availability can vary. Packaging is usually in protective blisters to preserve tablet quality.

Missed Dose and Timing

If a dose is missed, give it when remembered unless it is close to the next scheduled time. If it is near the next dose, skip the missed dose and resume the regular schedule. Do not double the dose to make up for a missed dose. Aim for consistent daily timing for best results.

Storage and Travel Basics

Store tablets at controlled room temperature, typically 68 to 77°F (20 to 25°C). Keep tablets in the original blister until use to protect from moisture and light. Keep out of reach of children and animals. When you travel or move the horse to events, carry tablets in their labeled packaging and avoid excessive heat, cold, or humidity.

Benefits

Prascend helps manage the clinical signs of PPID by addressing the hormone imbalance at the pituitary level. Benefits include:

• Once-daily oral dosing for straightforward routines
• Scored 1 mg tablet to allow flexible dose adjustments
• Label-supported therapy from Boehringer Ingelheim for PPID in horses
• Can be used long term with veterinary monitoring

Clinical goals often include improved attitude, more normal haircoat over time, and better overall comfort. Response varies by horse and disease severity.

Side Effects and Safety

Common adverse reactions reported with pergolide may include:

• Decreased appetite, especially at initiation
• Lethargy or decreased energy
• Diarrhea or soft stool
• Mild colic signs
• Weight loss
• Behavior changes
• Sweating or shivering

Serious or rare effects can include marked anorexia, significant lethargy, collapse, hypotension, or worsening of underlying conditions. If concerning signs occur, contact the prescribing veterinarian promptly. Horses starting therapy may experience transient appetite reduction; veterinarians may manage this by dose adjustments or timing strategies. Use caution in horses with cardiovascular, hepatic, or renal disease. The safety of use in breeding, pregnant, or lactating mares has not been established.

Drug Interactions and Cautions

Dopamine antagonists (such as phenothiazine tranquilizers or metoclopramide) may reduce pergolide’s effectiveness by blocking dopamine receptors. Concomitant use with medications that lower blood pressure could increase the risk of hypotension. Use caution when combining pergolide with other drugs affecting the central nervous system. Always provide the veterinarian with a complete medication and supplement list before starting Prascend.

What to Expect Over Time

PPID is a chronic condition that requires ongoing management. Many horses need lifelong therapy and regular veterinary rechecks. As treatment continues, clinical signs may improve gradually. The veterinarian will use clinical assessment and, when appropriate, hormone testing to fine-tune dosing. Consistent daily administration and follow-up help maintain long-term control of PPID signs.

Compare With Alternatives

There are no other branded, label-approved oral pergolide products for PPID in horses. If Prascend is not suitable or unavailable, veterinarians may discuss compounding options or supportive management such as diet, hoof care, and body condition monitoring. Any substitution should be guided by the prescribing veterinarian to ensure appropriate dosing and follow-up.

Pricing and Access

See current Prascend cost and Canadian pricing on this page, with US delivery from Canada. Many owners compare the Prascend price between 60 tablets and 160 tablets to plan longer supplies. Create an account, upload the veterinarian’s prescription, and place your order to have Prascend for horses ship to the US from Canada with prompt, express service. For current deals, visit our promotions page.

To browse other prescriptions or to bundle items, explore Pet Medications.

Availability and Substitutions

Inventory can change. If Prascend is temporarily unavailable, the prescribing veterinarian may recommend an alternative plan, including short-term monitoring or a compounded pergolide option. Any substitution should match the intended dose and be monitored by a veterinarian. Do not change or discontinue therapy without veterinary guidance.

Patient Suitability and Cost Saving Tips

Suitable candidates are horses diagnosed with PPID who can take oral medication daily and be monitored. Not all horses are candidates, including some with significant concurrent disease or mares that are breeding, pregnant, or lactating. Key tips:

• Ask the veterinarian about a multi-month supply to reduce order frequency.
• Consider 160 tablets when appropriate, which may help manage per-tablet cost.
• Use refill reminders so medication does not run out.
• If also ordering other equine prescriptions, bundling can be convenient. Some owners add routine dewormers like Strongid-P® or feed-through options such as Strongid-T® under veterinary advice.
• For horses managed with additional prescriptions, items like Furosemide Injection may be ordered together when prescribed.

Questions to Ask Your Clinician

• What starting dose of pergolide is appropriate for this horse?
• How will clinical response and ACTH or other endocrine tests be monitored?
• What signs suggest the dose should be adjusted?
• How should inappetence at the start of therapy be managed?
• Are there any medications or supplements that should be avoided?
• What long-term care plan supports PPID management, including diet and hoof care?

Authoritative Sources

• Boehringer Ingelheim Animal Health — Horses
• FDA Animal Drugs Database — PRASCEND
• Health Canada Drug Product Database

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