Prascend® Tablets for Equine Cushing’s Disease (PPID)

What Prascend Is and How It Works

Prascend® for horses is a veterinary prescription medicine used to manage pituitary pars intermedia dysfunction (PPID), also called equine Cushing’s disease. It contains pergolide, a dopamine agonist that helps reduce excess pituitary hormone activity. Ships from Canada to US with transparent pricing, including options for those without insurance. This page explains how it works, who it is for, and how to use it safely.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

This medicine acts on dopamine receptors to counter reduced dopaminergic tone in PPID. By restoring dopaminergic signaling, it can lower abnormally high ACTH levels. Over time, the treatment may help improve coat shedding, energy, and overall comfort when used under veterinary supervision.

Who It’s For

This treatment is for horses diagnosed with PPID by a veterinarian. It is not for humans or other species unless specifically directed by a licensed veterinarian.

Use of pergolide tablets may be limited in breeding, pregnant, or lactating mares because safety has not been fully established. Horses with hypersensitivity to pergolide should not receive it. Vets may use additional diagnostics, such as ACTH testing, to confirm the diagnosis and guide ongoing care. For background on the condition, see our resource on Equine Cushing’s Disease.

Dosage and Usage

Follow your veterinarian’s directions exactly. A typical starting plan is once daily dosing, with adjustments made based on clinical response and periodic lab results. Tablets are given by mouth and can be administered directly or with a small amount of feed to encourage acceptance.

If your vet instructs you to split tablets, use a proper tablet cutter for accuracy. Handle tablets with dry hands and return unused portions to the packaging. Avoid contaminating bulk feed. For clarity when discussing refills and administration, many owners refer to prascend tablets in their care notes, but always rely on your vet’s written instructions.

Never change the dose or stop therapy without veterinary guidance. Your veterinarian may recheck ACTH or clinical signs to refine the dosing plan. Record daily dosing to help avoid missed doses and to track your horse’s progress.

Strengths and Forms

This medicine is supplied as scored oral tablets. The commonly available strength is prascend 1 mg. Packs may vary by market and can include convenient multi-week supplies, such as 60-tablet and 160-tablet packs. Availability can differ based on inventory and dispensing pharmacy.

Missed Dose and Timing

If a dose is missed, give the next scheduled dose at the usual time. Do not double the next dose. Resume the regular schedule and contact your veterinarian if several consecutive doses are missed.

With pergolide tablets for horses, consistent daily timing can help maintain steady effects. Using a reminder helps reduce the chance of gaps in therapy. Keep dosing records with the feed chart or stall board for easy reference.

Storage and Travel Basics

Store tablets in the original packaging to protect them from moisture and light. Keep at room temperature as directed on the label. Do not store near heat sources, in tack rooms that overheat, or in damp areas like wash stalls.

Protect from children and other animals. Keep in a secure, closed container when traveling. Carry a copy of the prescription and your veterinarian’s contact information if you cross state or provincial borders. When moving between barns or events, place the medication with your horse’s labeled care kit to prevent mix-ups.

Benefits

This class of medicine addresses the underlying hormonal imbalance of PPID. When used as prescribed, it may help improve coat shedding, reduce excessive drinking and urination, and support a more stable body condition. Many owners also find that regular endocrine management supports farrier and dietary plans developed for PPID.

Daily oral dosing and scored tablets can simplify routine care. Keeping consistent administration, diet, and hoof care together may support overall outcomes as advised by your veterinarian.

Side Effects and Safety

• Decreased appetite, especially at initiation
• Lethargy or decreased activity
• Loose stools or mild digestive upset
• Sweating or behavior changes
• Weight loss if intake is insufficient

Serious or persistent adverse effects require veterinary evaluation. Horses with a history of laminitis need careful monitoring, as PPID is associated with metabolic changes. If your horse shows signs of colic, profound lethargy, severe inappetence, or laminitis, contact your veterinarian promptly. Your vet may temporarily adjust dosing or recommend supportive therapy if side effects occur.

Drug Interactions and Cautions

Dopamine antagonists, such as phenothiazines, may reduce the effect of this therapy. Acepromazine is commonly used as a sedative; discuss timing if your horse receives Atravet or similar medications before procedures or transport. Other interacting agents can include certain macrolide antibiotics or drugs affecting blood pressure. Always provide your vet with a complete medication and supplement list.

A valid prescription is required when you buy pergolide for horses online. Your veterinarian will determine if this therapy is appropriate and safe for your horse’s specific health status and concurrent treatments.

What to Expect Over Time

Expect your veterinarian to monitor clinical signs and, when indicated, measure ACTH or other markers. Early in therapy, appetite or behavior changes may occur; these are often transient but should be reported. Coat and body condition may evolve gradually with sustained management.

Regular hoof care, dietary adjustments, deworming schedules, and exercise programs tailored to PPID can complement endocrine control. Consistency helps your horse maintain a stable routine.

Compare With Alternatives

FDA-approved options for equine PPID are limited. Some clinicians consider adjunctive therapies in select cases, but pergolide remains the standard of care. Your veterinarian will advise whether any alternative or add-on therapy is appropriate based on clinical response and safety considerations.

Pricing and Access

Owners often ask about prascend cost when planning for long-term PPID care. We list current pricing by pack size so you can compare options. Multi-pack planning may reduce per-tablet expense compared to frequent small purchases, depending on your veterinarian’s prescription.

Canadian pricing with US shipping from Canada helps many owners manage budgets for chronic care. Check our site for refill-friendly pack sizes and dispensing details. If you track barn schedules and farrier cycles, align refill reminders with your horse’s routine. For seasonal offers, see Current Promotions.

Availability and Substitutions

Availability can vary. If the requested pack size is temporarily unavailable, your veterinarian may recommend a suitable alternative strength, a different pack size, or an interim refill plan to maintain continuity. We cannot guarantee restock dates, and substitutions require prescriber authorization when applicable.

Patient Suitability and Cost-Saving Tips

This treatment may be suitable for adult horses diagnosed with PPID who can reliably take oral tablets. Horses with suspected sensitivity to pergolide, or breeding, pregnant, or lactating mares, need individualized veterinary assessment. Report all supplements and concurrent medications for interaction review.

Cost-saving strategies can include 60- or 90-day fills when supported by your prescription, reminder setups, and aligning orders with routine barn deliveries. Some owners also plan routine parasite control and dental care to support overall health; for deworming discussions with your vet, see Panacur Paste. For additional veterinary supplies, browse Pet Medications.

Gastrointestinal support medicines may be used if your veterinarian recommends them; learn more about protective agents such as Sucralfate if digestive concerns arise alongside PPID care. Our educational library also covers small-animal topics for households with multiple pets; a starting point is the Doxycycline Guide.

Questions to Ask Your Clinician

• Confirming diagnosis: Which tests confirmed PPID and when to recheck
• Dose plan: Starting dose, titration steps, and monitoring schedule
• Side effects: What to watch for in the first weeks
• Diet and hoof care: How to coordinate feed, pasture access, and farrier visits
• Drug interactions: Timing around sedatives, antibiotics, and supplements
• Long-term plan: Goals for coat, weight, and comfort over seasons
• Refills and packs: Which pack size suits adherence and barn logistics

Authoritative Sources

For official product and safety information, consult these sources:

• Boehringer Ingelheim Animal Health: Prascend Product Information
• FDA Center for Veterinary Medicine: Prascend FOI Summary
• FDA Animal Drugs: Prascend Approval Listing

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Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.