Sileo® Oromucosal Gel for Noise Aversion in Dogs

Sileo® Gel is a dexmedetomidine oromucosal gel for dogs with noise aversion. This page explains how it works, how to use it, and how to access Canadian pricing, including options if you are paying without insurance. It is supplied from Canada and ships to the US with prompt, express shipping.

What Sileo® Is and How It Works

Sileo is a prescription dexmedetomidine oromucosal gel formulated for dogs. It helps manage acute fear and anxiety from loud sounds, such as fireworks or thunderstorms. The gel is given in the cheek pouch, so it works through the oral mucosa rather than the stomach. This route helps reduce stress quickly without needing a pill or injection.

Dexmedetomidine is an alpha-2 adrenergic agonist. It lowers norepinephrine release in the brain. This calms the dog and decreases the behavioral signs of noise aversion. Many pet owners find that an oromucosal option is easier to use during stressful events. The labeled regimen also allows repeat dosing during a single noise event when advised by your veterinarian.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

Who Sileo® Is For

Sileo Gel is indicated for the treatment of noise aversion in dogs. It can help dogs that panic or hide during fireworks, thunder, construction noise, or similar sounds. Your veterinarian will confirm the diagnosis and decide if this medicine suits your dog’s health history.

Use caution in dogs with heart, liver, kidney, or respiratory disease. Safety has not been established in puppies under 16 weeks, or in breeding, pregnant, or lactating dogs. Do not use in cats. Avoid use with other sedating drugs unless your veterinarian directs it.

Dosage and Usage

Your veterinarian will provide a weight-based dosing chart and show you how to set the syringe. Give Sileo at the first sign of noise-related anxiety or when a predictable noise event is starting. Place the pre-measured amount between the dog’s cheek and gum. Do not feed immediately before or after you give the gel so it can absorb across the cheek.

Depending on the event length and your vet’s instructions, you may repeat a dose after a minimum interval. Do not exceed the labeled maximum number of doses during a single noise event. Never change your dog’s dose without veterinary guidance.

Strengths and Forms

Sileo 0.1 mg/mL oromucosal gel comes in a 3 mL multi-dose, metered oral syringe. The syringe has a lockable ring that helps you select the correct amount based on your dog’s body weight. Each syringe contains several doses, depending on your dog’s size and the prescribed amount. Availability may vary.

Missed Dose and Timing

If you were planning a dose and missed the early window, give Sileo as soon as your dog shows noise aversion signs, if your vet has approved use for that event. If you are considering a repeat dose, wait at least the labeled interval between doses. Do not give extra gel to replace a dose that may have been spit out or swallowed with food. When in doubt, contact your veterinarian before giving more.

Storage and Travel Basics

Store Sileo at room temperature in the original carton. Keep the syringe capped and locked between uses. After the first opening, use within the timeframe on the label, commonly within 4 weeks. Keep out of reach of children and other pets.

For travel, carry Sileo in a sealable bag with the prescription label attached. Protect it from extreme heat or freezing. This product does not require cold-chain handling. Do not share with other pets.

Benefits

• Targeted relief of noise aversion behaviors in dogs.
• Oral transmucosal dosing avoids swallowing a pill during stress.
• Metered syringe helps deliver the prescribed amount.
• Can be repeated during a noise event per label and vet advice.
• Non-invasive option compared with injections.
• Backed by veterinary prescribing and safety oversight.
• Canadian pricing with US delivery from Canada.

Side Effects and Safety

• Mild to moderate sedation or drowsiness.
• Pale gums or slowing heart rate.
• Tremor, ataxia, or unsteadiness.
• Vomiting or drooling.
• Urinary accidents in some dogs.
• Transient behavioral changes during the noise event.

Serious but less common effects may include profound sedation, low blood pressure, very slow heart rate, cyanosis, or collapse. Overdose can be dangerous. Keep this and all medicines away from children. If you see concerning signs, contact a veterinarian or emergency clinic immediately.

Drug Interactions and Cautions

Use Sileo carefully with other sedatives, tranquilizers, or anesthetics. Combining central nervous system depressants can increase sedation or affect blood pressure and heart rate. Tell your veterinarian about all medicines, supplements, and topical products your dog receives, including flea and tick preventives or herbal products.

Dogs with significant cardiac disease, respiratory compromise, shock, or severe systemic illness may not be good candidates. Your veterinarian will weigh risks and benefits for dogs with liver or kidney impairment. Follow veterinary instructions on timing around food, dose spacing, and repeat dosing limits.

What to Expect Over Time

Many dogs show calmer behavior during the noise event after the dose is absorbed through the cheek. The response can vary by dog, intensity of the sound, and environment. A quiet, safe room and a calming routine can help. Behavior strategies and training plans may further improve results across seasons. For broader pet care education, you can read related guides like Apoquel For Dogs and Arthritis In Dogs.

Compare With Alternatives

Your vet may consider other options based on diagnosis and medical history. Injectable dexmedetomidine is used by veterinarians for sedation in clinical settings and is not a direct substitute for at-home noise aversion dosing. To understand how clinic-administered options differ, review Dexdomitor® Vial and Dexvetidine® Vial. These are professional-use products; any use should follow veterinary direction only.

Pricing and Access

You can view Sileo Gel Canadian pricing and request US delivery from Canada. Many pet owners compare the total out-of-pocket cost for Sileo Gel for Dogs against other therapies. Check current pricing and typical cash-pay savings before you place your request. For occasional site offers, visit our Promotions. Checkout is encrypted to help protect your information.

Availability and Substitutions

If Sileo 0.1 mg/mL Oromucosal Gel for Dogs is temporarily unavailable, your veterinarian may recommend another plan. In some cases, a different agent may be considered. For example, oral acepromazine tablets like Atravet® may be discussed, or an injectable sedative such as Acevet® 25 Injectable for in-clinic use. These are not one-to-one substitutes for Sileo’s labeled indication.

You can also browse our broader Pet Medications selection to see related pet therapies. Stock status can change, so your veterinarian’s guidance will help you pick a safe alternative if needed.

Patient Suitability and Cost Saving Tips

• Good candidates are dogs with diagnosed noise aversion and no major cardiac disease.
• Avoid or use caution in pregnant, breeding, or lactating dogs unless your vet approves.
• Discuss your dog’s full medication list to reduce interaction risks.
• Plan ahead for fireworks season with enough supply based on your vet’s dosing chart.
• Ask about multi-syringe requests if many events are expected.
• Set reminders for refill timing and gel replacement after first opening.
• Compare Canadian pricing for Sileo Gel US shipping to manage costs.

Questions to Ask Your Clinician

• Is Sileo Gel for Dogs appropriate for my dog’s noise triggers?
• How should I set the dose ring for my dog’s weight?
• How long should I wait between repeat doses during one event?
• What side effects should I watch for, and when should I call?
• Can Sileo be used with other behavior or training strategies?
• Are there medicines my dog should avoid on Sileo days?
• How many syringes should I keep on hand for the season?

Authoritative Sources

• Zoetis Sileo Product Page
• FDA Animal Drugs: Sileo (NADA 141-447)
• Sileo Prescribing Information (PI)

Start your request for Sileo Oral Gel for Dogs with US delivery from Canada. This information is educational and does not replace your veterinarian’s advice.