Sileo® Oromucosal Gel for Dogs

Sileo® Gel is a veterinary dexmedetomidine oral formulation used to help dogs during noise events. It is given into the cheek pouch so it absorbs through the mouth lining. This page explains what it is, how to use it safely, and how to access it with US delivery from Canada, including options if you pay without insurance.

What Sileo Is and How It Works

This medicine contains dexmedetomidine, an alpha-2 adrenergic agonist. It reduces the physiologic arousal linked to sudden loud sounds such as fireworks or thunderstorms. When placed between the dog’s cheek and gums, it is absorbed through the oral mucosa and may lessen fear responses. It is not a tranquilizer in the traditional sense; rather, it calms by decreasing norepinephrine signaling in the central nervous system.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

Veterinarians prescribe this treatment for the management of noise aversion. It is used as needed at the onset of noise, with the potential for repeat dosing during ongoing events under the labeled schedule.

Who It’s For

This treatment is intended for canine patients with established sensitivity to loud or unexpected sounds. Dogs that pace, tremble, hide, or vocalize during storms or fireworks may be candidates. It helps reduce acute signs without changing behavior outside of noise events.

The phrase sileo for dogs refers to this labeled use in canines. Dogs with severe heart disease, significant liver impairment, or those in shock or very debilitated states should not receive this class without specific veterinary guidance. It is not approved for use in people or other species.

To learn more about the condition itself, see our overview of Canine Noise Aversion.

Dosage and Usage

Follow your veterinarian’s instructions and the manufacturer’s label. The syringe is designed with a dosing ring and gradations corresponding to body weight bands. Give the first dose when your dog shows the earliest signs of fear related to noise, or shortly before a predictable event when instructed by your veterinarian.

Administer by placing the tip between the cheek and gum and pressing the plunger to release the measured amount. Do not let your dog swallow the gel directly; absorption is intended through the mouth lining. If needed during a prolonged event, a repeat dose may be given after a waiting interval, typically no sooner than two hours. Do not exceed the allowed number of doses per event as stated on the label.

The term sileo gel dosage appears on many dosing charts online; however, always confirm the exact weight-based setting on the syringe with your veterinarian. After dosing, avoid giving food immediately so the gel can remain in contact with the cheek pouch. Replace the cap securely and store the device as directed.

Strengths and Forms

This product is supplied as a prefilled oromucosal gel in a multi-dose syringe for canine use. A commonly referenced concentration is 0.1 mg/mL dexmedetomidine. The device includes a plunger, cap, and a locking ring to set the measured amount.

Pack sizes and regional presentations may vary by manufacturer lot and market. Some owners search for sileo 3ml, which refers to a syringe fill volume available in many markets. Your veterinarian will advise the correct presentation for your dog’s weight and treatment plan.

Missed Dose and Timing

If you intended to give a dose at the onset of a noise event and missed it, give it when you first notice fear-related signs, as long as the dog is calm enough to handle safely. Do not stack doses too closely. Keep the labeled minimum interval between doses, and do not exceed the maximum number per noise event. If signs persist or worsen despite use, contact your veterinarian for guidance.

Storage and Travel Basics

Store at room temperature in a dry place away from direct sunlight. Keep the cap tightly replaced after use, and ensure the dosing ring remains at the correct setting before the next administration. As with any veterinary medicine, keep out of reach of children and other animals.

If you travel with your dog during storm seasons or holidays, carry the syringe in its carton. Bring a copy of your prescription and your veterinarian’s instructions if you cross state lines. Avoid extreme temperatures in cars or luggage. If the gel appears discolored or the device is damaged, consult your pharmacist or veterinarian before use.

Benefits

As an oromucosal gel for dogs, this treatment offers on-demand use at the first signs of noise stress. Owners can administer it at home without needles. The dosing ring and weight-based markings support consistent delivery. Many dogs remain responsive to surroundings while calmer, which may help with comfort measures your veterinarian recommends.

Side Effects and Safety

Common effects can include mild to moderate sedation, drowsiness, or lethargy. Some dogs may show pale gums, slow heart rate, unsteady gait, or vomiting. Excess salivation may occur if the gel is swallowed rather than held in the cheek pouch. Most effects are transient and relate to dose and sensitivity.

As a dexmedetomidine oromucosal gel, the treatment can lower heart rate and blood pressure. Serious but less common risks may include profound sedation, significant bradycardia, or hypotension, particularly if other sedatives are used. Dogs with cardiac disease, severe hepatic impairment, respiratory compromise, or those who are very young, geriatric, pregnant, or nursing require individualized veterinary assessment. If your dog collapses, has trouble breathing, or shows persistent vomiting, seek urgent veterinary care.

• Common effects: sleepiness, lethargy, pale gums
• Gastrointestinal: vomiting, transient drooling
• Neurologic: unsteady gait, reduced responsiveness
• Cardiovascular: slow heart rate, low blood pressure

Report unexpected or severe reactions to your veterinarian. Keep a record of the dose time, amount, and your dog’s behavior to assist clinical decision-making.

Drug Interactions and Cautions

Use caution with other central nervous system depressants, including trazodone, benzodiazepines, opioids, or certain antihistamines. Combining sedating agents can deepen effects. Beta-blockers, calcium channel blockers, or antiarrhythmic drugs may have additive impacts on heart rate and blood pressure. Discuss all medicines, supplements, and preventives your dog receives.

Do not use in dogs with known hypersensitivity to dexmedetomidine. Use veterinary supervision in dogs with cardiac conduction abnormalities, severe systemic disease, or those at risk for dehydration or shock. Avoid food immediately after dosing to maintain cheek contact time.

What to Expect Over Time

Onset can be gradual as the gel absorbs through the oral tissues. Your dog may appear calmer and less reactive to loud sounds while remaining arousable. Effects can vary by individual sensitivity, noise intensity, and timing of dose. Keep your dog in a quiet, safe space during noise events, and combine use with your veterinarian’s behavior and environmental strategies.

Track response over several events. Note triggers, timing, and dose settings to refine your plan with your veterinarian. Consistent preparation around predictable events, like holidays, may help improve overall control of signs.

Compare With Alternatives

Veterinarians may consider other options depending on your dog’s medical history and response. For situational sedation, some clinicians use oral acepromazine; see Atravet when appropriate. In clinic or procedural settings, injectable dexmedetomidine may be selected; see Dexvetidine Vial as an example of that class. Each option differs in onset, depth of effect, and monitoring needs.

Selection should be individualized. Do not substitute or combine medicines without veterinary approval.

Pricing and Access

Canadian pricing can offer meaningful savings compared to typical US cash costs. You can review the sileo price once your prescription is ready to process. For broader comparisons across categories, visit Pet Medications. We provide checkout with encryption and clear itemization.

Orders are processed for US shipping from Canada. If you are looking for current seasonal offers, see our Promotions page. Final pricing may vary by strength, syringe count, and dispensing pharmacy.

Availability and Substitutions

Supply can vary by market and season. If the product is temporarily unavailable, your veterinarian may recommend an alternative or interim plan. For example, another dexmedetomidine presentation may be considered in clinical settings; see Dexmedesed Vial for reference. Any substitution requires a clinician’s direction.

Patient Suitability and Cost-Saving Tips

This treatment may suit dogs that experience predictable or repeated noise triggers and are otherwise healthy. Dogs with significant cardiovascular, hepatic, or respiratory disease require careful evaluation. It is not intended for daily long-term anxiety management outside of noise events unless directed by a veterinarian.

To reduce overall costs, ask your veterinarian about multi-event planning and whether a larger supply aligns with your dog’s weight and the labeled dose limits. Consider setting refill reminders before holidays or storm seasons. Some owners choose to buy sileo for dogs ahead of travel plans or expected celebrations so they are prepared.

Questions to Ask Your Clinician

• Right candidate: Is my dog an appropriate patient for this class?
• Dose plan: What syringe setting matches my dog’s weight?
• Repeat dosing: How many repeats are allowed per event?
• Combinations: Can I use it with my dog’s other medicines?
• Timing: When should I give the first dose before expected noise?
• Monitoring: What signs mean I should contact you or seek urgent care?

Authoritative Sources

For official prescribing and safety information, consult these sources:

• Manufacturer information from Zoetis provides product details and labeled use
• FDA Center for Veterinary Medicine listing includes approval and labeling resources
• FDA Freedom of Information Summaries describe safety and effectiveness findings

Ready to proceed? You can place your request online with prompt, express, cold-chain shipping with temperature-controlled handling when required. Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.