Sileo® Oromucosal Gel for Noise Aversion in Dogs

Sileo® Gel is a dexmedetomidine oromucosal medicine for canine noise aversion. It helps calm acute fear signs during fireworks, thunderstorms, and similar events. This page explains how it works, who it suits, and how to order with US shipping from Canada, including options for Sileo Gel without insurance.

What Sileo Is and How It Works

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

This medicine contains dexmedetomidine, an alpha-2 adrenergic agonist. It reduces release of norepinephrine, which can help lessen arousal and fear responses. The gel is placed in the cheek pouch so it can be absorbed through the oral mucosa.

As an Oromucosal Gel for Dogs, it is given at home at the first signs of noise-related distress. It may reduce pacing, panting, trembling, and hiding. Some dogs may become drowsy; effects vary based on the individual and the prescribed amount.

Who It’s For

This treatment is used for dogs with acute noise aversion triggered by events such as fireworks, thunderstorms, construction, or celebrations. Dexmedetomidine Oromucosal Gel for Dogs may not be appropriate for animals with significant cardiovascular, liver, or kidney disease. Dogs with severe systemic illness, or those that are very young, pregnant, breeding, or lactating, require careful veterinary guidance.

Tell the prescriber about all conditions and medicines your dog uses. This includes any calming supplements or sedatives. The clinician will determine if this therapy is appropriate and how it should be used for your pet.

Dosage and Usage

Follow the veterinary prescription and the package insert exactly. Administer the gel into the space between the cheek and gum, not on the tongue. Avoid food and water immediately after dosing so the medicine can be absorbed properly. Keep your dog calm indoors when possible during the event.

Start at the first sign of distress. A repeat dose may be considered if signs return, according to your prescriber and the label. Do not exceed the maximum daily amount on the package insert. If you are uncertain about timing, ask your veterinarian before re-dosing. Dexmedetomidine Oromucosal is centrally acting, so more is not always better; use only as directed.

Tips for administration:

• Wear disposable gloves when handling the syringe.
• Lock the stop ring at the prescribed mark before dosing.
• Lift the lip and place the tip against the gum line.
• Depress the plunger slowly to avoid swallowing.
• Discard any removable cap safely after use.

If your dog vomits, swallows the gel, or expels it, contact your veterinarian for guidance on whether and when to repeat the dose.

Strengths and Forms

The product is supplied as a ready-to-use oral syringe intended for mucosal application. Common presentations include a multi-dose syringe with a locking stop-ring to set the prescribed amount. Availability may vary by pharmacy and jurisdiction.

• Concentration: 0.1 mg/mL dexmedetomidine
• Presentation: 3 mL multi-dose oral syringe with dose markings

This Oromucosal Gel for Dogs is designed for measured at-home administration using the provided syringe. Check your packaging for specific markings and instructions.

Missed Dose and Timing

This therapy is given as needed for noise events, not as a routine daily regimen. If signs recur during the same event, your prescriber may allow additional dosing after a waiting period. If you miss a planned dose before an anticipated event, administer when you first notice fear behaviors, if still appropriate. Never give extra amounts to make up for a missed dose. Consult the official label or your veterinarian if unsure.

Storage and Travel Basics

Store at room temperature in the original packaging. Keep the syringe capped and secured from children and animals. Protect from excessive heat and from direct light. Do not use after the labeled expiration date. If traveling, carry the labeled syringe and a copy of your prescription. Pack it in your hand luggage to avoid extreme conditions and inspect the device before use.

Dispose of used gloves and packaging in household trash unless local rules differ. Do not rinse the syringe or attempt to refill it. If you need to travel during noise seasons, plan ahead so you have enough on hand based on your veterinarian’s guidance.

Benefits

This therapy can:

• Target acute noise aversion signs during triggering events
• Allow at-home dosing without a clinic visit
• Use a measured, locked amount for each administration
• Offer mucosal absorption without swallowing tablets
• Be repeatable during an event when directed by a prescriber

Not all dogs respond the same way. Some will appear calm yet alert, while others may become drowsy. Work with your veterinarian to prepare a plan for common triggers.

Side Effects and Safety

Common effects may include:

• Drowsiness or sedation
• Pale mucous membranes
• Lowered heart rate
• Vomiting or gagging
• Urination changes

More serious risks can include pronounced sedation, low blood pressure, slow heart rate, or breathing changes. Dogs with significant cardiac disease require particular caution. If your dog collapses, cannot be roused, or shows severe distress, seek urgent veterinary care. Report adverse effects to your clinician and note dose amounts and timing.

Drug Interactions and Cautions

Tell your veterinarian about all medicines and supplements your dog receives. Central nervous system depressants, certain anesthetics, or other sedatives can increase drowsiness when combined. Use caution with drugs affecting heart rate and blood pressure. Avoid alcohol-containing products and flavorings when administering the dose. If your dog has liver, kidney, or heart conditions, discuss risks and monitoring before use.

What to Expect Over Time

With correct use, signs of acute fear may lessen during a noise event. Some dogs will rest quietly; others remain calm but responsive. The need for re-dosing depends on the duration and intensity of the trigger and your veterinarian’s plan. Keep a record of events, dose amounts, and behavior changes. Share this log at follow-up visits so your clinician can refine your dog’s plan.

Compare With Alternatives

Depending on your dog’s health and triggers, a prescriber may suggest other options. Sedatives or tranquilizers are sometimes used when appropriate. Two prescription alternatives available here include Atravet® tablets and Acevet® 25 Injectable. These are different medicines and have distinct safety profiles. Your veterinarian will determine suitability.

Pricing and Access

See current pricing on this page and compare options. You can review availability, add the item to your cart, and upload or send your prescription for verification. Many pet owners seek savings for ongoing seasonal needs. We list transparent pricing, so you can evaluate total costs and plan for upcoming events.

Ordering through CanadianInsulin provides Canadian pricing with US delivery from Canada. If you watch for site specials, you may find extra value; see our Promotions page for current offers. If you are comparing vendors, consider doses, fulfillment fees, and taxes together when assessing overall value.

For searchers tracking costs, we also list Sileo Price and presentation details here so you can plan refills around common noise seasons.

Availability and Substitutions

Supply can vary. If this product is not available, a prescriber may recommend an alternative with a similar purpose. Do not substitute without veterinary direction. Check back on this page for current status, or contact support to confirm what your prescription allows.

Patient Suitability and Cost-Saving Tips

This therapy may suit healthy adult dogs with predictable noise triggers. Dogs with heart disease, severe systemic illness, or special conditions require individualized assessment. If your pet needs doses across a season, ask your veterinarian about an adequate number of syringes for the period. Consider setting refill reminders before holidays or storm seasons.

Ways to reduce overall costs include ordering multiple items together when appropriate, using the same cart for routine Pet Medications, and checking site specials. Keep an event log so you and your prescriber can optimize when to dose and how much to keep on hand.

Questions to Ask Your Clinician

• Is this medicine appropriate for my dog’s heart and liver status?
• What signs show it is time to give a dose during an event?
• How long should I wait before considering a second dose?
• Which side effects require a phone call or urgent care?
• Can I use this with my dog’s other calming medicines or supplements?
• How many syringes should I keep for the upcoming season?
• What handling steps reduce swallowing and improve mucosal contact?

Authoritative Sources

Zoetis Sileo Product Page

FDA FOI Summary: Sileo (dexmedetomidine)

Health Canada Drug Product Database

Ready to proceed? CanadianInsulin offers secure checkout and prompt, express shipping with temperature-controlled handling when required. Ships from Canada to US. This information is for educational purposes and does not replace your veterinarian’s advice.