Simparica® Chewable Tablets for Dogs

Simparica® for dogs is a prescription chewable used to control fleas and ticks. This page explains how it works, when it is used, and how to place an order with US delivery from Canada. You can review pricing without insurance.

What Simparica Is and How It Works

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

This medicine contains sarolaner, an isoxazoline ectoparasiticide. It targets flea and tick nervous systems by blocking ligand-gated chloride channels, which leads to paralysis and death in these parasites. The treatment provides sustained activity across the month when given on schedule. It reduces flea burdens on dogs and helps disrupt the flea life cycle by killing adult fleas before they can lay eggs.

Tick coverage includes several common species found on dogs. By reducing tick attachment and survival, the therapy helps lower the chance of tick-borne pathogen transmission. Always use the product as directed on the approved label, and pair with environmental control when infestations are heavy.

Who It’s For

This therapy is indicated for dogs 6 months of age and older, weighing at least a few pounds per labeled guidance. It is used for the prevention and treatment of flea infestations and for the treatment and control of several tick species. It is not for use in cats.

Dogs with a history of seizures, tremors, ataxia, or other neurologic disorders may be at higher risk for adverse reactions. Safety in breeding, pregnant, or lactating dogs has not been firmly established. For gastrointestinal parasite coverage, your prescriber may discuss separate options; see additional reading on Tapeworm Treatment.

Dosage and Usage

Give one Simparica chewable once monthly as directed by your veterinarian. Administer the full chewable tablet. You may offer it by hand, with food, or mixed into a small treat, ensuring the entire dose is consumed. If a portion is crumbled or dropped, provide a replacement tablet only if directed by your prescriber.

Use the weight-appropriate tablet size based on your dog’s current body weight. Start dosing at least one month before peak flea and tick exposure in your area and continue monthly year-round or as advised on the label. Maintain a consistent monthly schedule for reliable protection.

Strengths and Forms

These are flavored chewable tablets supplied in weight-bracketed strengths. Strengths correlate to body weight ranges. For example, Simparica 11 22 suits many midweight dogs in the 11–22 lb range. Availability can vary by region and season.

• 5.6–11 lb dogs: chewable tablet sized for small dogs
• 11–22 lb dogs: tablet sized for small-to-medium dogs
• 22–44 lb dogs: tablet sized for medium dogs
• 44–88 lb dogs: tablet sized for large dogs
• 88–132 lb dogs: tablet sized for extra-large dogs

Follow the carton or blister labeling for the exact milligram strength and weight guidance for each presentation.

Missed Dose and Timing

If a monthly dose is missed, give it when remembered, then resume the regular monthly schedule. Dogs may lose consistent Simparica flea and tick coverage if intervals stretch too far between doses. Do not double up on tablets to “catch up” unless specifically instructed by your veterinarian.

Maintaining a simple reminder system, such as calendar alerts, can help keep the monthly interval on track. Ask your prescriber how to proceed if your dog is significantly overdue.

Storage and Travel Basics

Store the chewable tablets at standard room temperature in the original blister or carton, and keep them dry. Protect from excessive heat and direct sunlight. Keep out of reach of children and other animals.

For travel, carry tablets in the labeled package along with a copy of your pet’s prescription or a photo of it. Pack enough tablets for the full trip plus a buffer in case plans change. When flying, place doses in a carry-on to avoid lost baggage. Do not repack tablets into unlabeled containers.

Benefits

This class of treatment offers practical advantages for many households.

• Flea control: kills adult fleas and helps prevent re-infestation
• Tick coverage: targets multiple common tick species
• Monthly schedule: simple routine that supports adherence
• Oral dosing: no residues on fur or household surfaces
• Palatable chew: designed to be easy to give
• Weight-based sizes: tailored tablets across common ranges

Side Effects and Safety

Commonly reported effects include vomiting, diarrhea or soft stool, decreased appetite, lethargy, and pruritus. Most effects are transient. Administering with a small meal may help with mild stomach upset for some dogs.

• Gastrointestinal upset: vomiting, diarrhea, reduced appetite
• Lethargy: decreased activity, usually short-lived
• Skin signs: itching or redness in some dogs

Serious or rare reactions can occur. Isoxazolines have been associated with neurologic adverse events, including tremors, ataxia, and seizures in dogs with or without a prior history. Discontinue and contact a veterinarian if neurologic signs, persistent vomiting, facial swelling, or difficulty breathing occur. Report suspected adverse events to your prescriber and the manufacturer as directed on the label.

Drug Interactions and Cautions

This medicine has been used alongside many routine veterinary therapies, including some heartworm preventives and vaccines. However, interactions are not fully characterized, and individual risk varies with comorbid conditions and concurrent medicines. Use with caution in dogs with a seizure history or neurologic disorders.

Always share a full medication list, including over-the-counter supplements and preventives, with your prescriber. For broader options and related items, see our Pet Medications section.

What to Expect Over Time

With steady monthly dosing, flea populations on the pet typically decline as adults are killed. Environmental stages may persist for a period, so comprehensive control often includes home and yard measures. Tick exposure depends on season and geography; maintaining regular dosing helps address ongoing risk when dogs are outdoors.

Keep a monthly reminder and align doses with routine dates, such as the first of the month. Ask your veterinarian about integrated parasite management, including environmental cleaning and mechanical tick checks after hikes or boarding stays.

Compare With Alternatives

For rapid knockdown of existing fleas, a single-dose oral nitenpyram may be discussed as an add-on; see Capstar® For Dog. For a topical monthly option that also addresses fleas and certain ticks, your prescriber may consider selamectin-based therapies; see Revolution® For Dog. Choice depends on your dog’s age, weight, household needs, and regional parasite pressures.

Pricing and Access

Compare sizes and check the Simparica price for your dog’s weight bracket. Orders are fulfilled with Canadian pricing and US shipping from Canada. You can view current costs, select a tablet size, and proceed through our encrypted checkout.

For general guidance on affordability, see Affordable Options. Periodic offers may be listed on our Promotions page.

Availability and Substitutions

Supply can vary by strength and demand. If an item is temporarily unavailable, your prescriber may recommend a comparable alternative for parasite control. You can confirm stock and place an order for Simparica online once your veterinarian approves the prescription. We cannot guarantee restock dates.

Patient Suitability and Cost-Saving Tips

• Right candidate: healthy dogs 6 months and older, appropriate weight
• Use caution: seizure history, neurologic disorders, breeding or pregnant dogs
• Not for: cats or very young puppies below labeled age
• Seasonal planning: discuss year-round vs seasonal dosing with your veterinarian
• Multi-month orders: reduce clinic trips and help maintain monthly adherence
• Reminders: set calendar alerts to avoid late doses
• Budgeting: compare sizes by weight bracket; consider cash price when you pay out of pocket

Questions to Ask Your Clinician

• Is this class appropriate for my dog’s age, weight, and health status?
• Which tick species are common in our area each season?
• How should I handle dosing if my dog spits out or vomits a tablet?
• Can I use this with my current heartworm preventive?
• What environmental steps help reduce flea re-infestation at home?
• What signs of adverse reactions should I watch for after each dose?
• When should I schedule follow-up to reassess parasite control?

Authoritative Sources

Zoetis: Simparica Product PageFDA CVM: NADA 141-457 FOI SummaryHealth Canada DPD: Sarolaner

Ready to proceed? Order today for care that Ships from Canada to US with express shipping. This information is educational and does not replace your veterinarian’s advice. Always follow the approved label.