Please note: a valid prescription is required for all prescription medication.
Synthroid® is a brand of levothyroxine, a thyroid hormone replacement. It treats underactive thyroid by restoring normal hormone levels. Canadian pricing may lower your out-of-pocket costs, and it ships to the US. You can buy Synthroid online through CanadianInsulin with or without insurance.
CanadianInsulin connects patients with licensed Canadian pharmacies. Prescriptions are verified with your clinic before dispensing.
What Synthroid® Is and How It Works
Synthroid is a synthetic form of thyroxine, also called T4. Your body converts T4 into the active hormone T3 in tissues. This restores normal metabolism, energy, and growth processes. When taken consistently, the medicine helps bring TSH and thyroid hormones back to target levels.
Synthroid works best when taken the same way every day. Absorption is highest on an empty stomach. Small changes in dose or timing can change thyroid levels. Your clinician uses TSH blood tests to fine-tune your dose.
Who Synthroid® Is For
Synthroid treats primary, secondary, and tertiary hypothyroidism in adults and children. It is also used to suppress TSH after thyroid cancer treatment, when prescribed. People with stable coronary artery disease or arrhythmia may need cautious dosing and close monitoring.
Do not use levothyroxine to treat weight loss or obesity. Using thyroid hormones for weight control can cause serious or life‑threatening effects, especially with other stimulants. Do not take Synthroid if you have uncorrected adrenal insufficiency.
If you are unsure whether your symptoms are due to hypothyroidism, talk with your clinician. For more options related to this condition, see the Hypothyroidism category.
Dosage and Usage
Dosing is individualized. Many healthy adults start around 1.6 micrograms per kilogram once daily. Older adults or those with heart disease often start at 12.5 to 25 mcg daily. Your provider adjusts by 12.5 to 25 mcg every 6 to 8 weeks based on TSH.
Take Synthroid once daily on an empty stomach. Swallow with water 30 to 60 minutes before breakfast. You may also take it at bedtime, at least 3 to 4 hours after the last meal. Use the same schedule every day.
Some medicines and supplements reduce absorption. Separate Synthroid by at least 4 hours from iron, calcium, antacids, and bile acid sequestrants. If your dosing situation is unusual, defer to the FDA label and your prescriber’s guidance.
Strengths and Forms
Synthroid is available as color-coded oral tablets. Common strengths include 25, 50, 75, 88, 100, 112, 125, 137, 150, 175, and 200 mcg. Availability may vary by pharmacy and country. Your exact strength aims to match your TSH target without overshooting.
Missed Dose and Timing
If you miss a dose, take it when you remember that day. If it is near the next dose, skip the missed dose and resume your schedule. Do not double up. Try to keep the same timing each day to maintain steady levels.
Consistency helps more than the exact hour. Choose a routine that fits your mornings or evenings. Keep iron, calcium, and fiber supplements well separated from your dose.
Storage and Travel Basics
Store tablets at room temperature, typically 20 to 25°C (68 to 77°F). Protect from heat, moisture, and light. Keep tablets in the original container with the desiccant. Do not store in the bathroom.
When you travel, keep your medicine in your carry-on. Bring your prescription label for security checks. Stay on your once-daily schedule across time zones. You can adjust by a few hours without harm. Take the next dose at your usual local morning or bedtime schedule.
Benefits
When dosed correctly, Synthroid helps relieve tiredness, cold intolerance, dry skin, and slowed thinking. It supports heart, digestive, and muscle function. It also helps normalize cholesterol that rose due to hypothyroidism. Once stable, most people need only periodic TSH checks and small dose changes over time.
Tablets offer precise dosing across many strengths. Brand-name manufacturing aims for consistent potency from lot to lot. That consistency can simplify TSH monitoring for some patients.
Side Effects and Safety
- Headache
- Nervousness or irritability
- Palpitations or faster heartbeat
- Heat intolerance and sweating
- Tremor
- Trouble sleeping
- Diarrhea or weight changes
These effects often indicate an overly high dose. Serious risks can include chest pain, arrhythmias such as atrial fibrillation, or signs of thyrotoxicosis. Long-term overtreatment may reduce bone density, especially in postmenopausal women. Severe reactions are rare but require urgent care.
Call your clinician if you develop chest pain, shortness of breath, severe anxiety, or rapid irregular heartbeat. If you have known adrenal insufficiency, it must be treated before starting levothyroxine.
Drug Interactions and Cautions
Common absorption interactions include iron, calcium, aluminum- and magnesium-containing antacids, sucralfate, and bile acid sequestrants like cholestyramine or colesevelam. Separate these by at least 4 hours. High-fiber diets and soy can also reduce absorption for some people.
Medicines that may change thyroid levels include carbamazepine, phenytoin, phenobarbital, rifampin, amiodarone, and sertraline. Estrogen therapy can raise thyroxine needs. Thyroid hormone can potentiate warfarin’s anticoagulant effect, so INR monitoring may be needed when doses change. Diabetes medications may need adjustment as thyroid status normalizes.
Tell your prescriber about all medicines, vitamins, and supplements you take. Avoid switching brands or generics without a plan to recheck TSH.
What to Expect Over Time
Many people begin to feel better within a few weeks. TSH usually reaches a new steady state 6 to 8 weeks after a dose change. Your clinician will adjust slowly to avoid overshooting. Stable patients often check TSH every 6 to 12 months.
Consistency matters. Take Synthroid the same way, at the same time, and from the same brand or manufacturer when possible. If your tablets look different or the pharmacy changed suppliers, ask whether a TSH recheck is needed.
Compare With Alternatives
Generic levothyroxine tablets offer the same active ingredient at varying prices. Some patients may prefer a specific brand for consistent TSH results. Other brands include Levoxyl and Unithroid tablets. Tirosint is a levothyroxine capsule without dyes or lactose, which may help in certain intolerances. Dosing and monitoring principles remain the same across options.
Pricing and Access
Canadian pricing can help reduce your Synthroid cost compared with many US cash prices. You can view the current Synthroid price online and compare strengths. Orders ship from Canada to the US with prompt delivery. Checkout is encrypted for your protection.
You can order Synthroid tablets online and see potential savings without insurance. Upload your prescription, and we will coordinate verification with your clinic. If your dose changes after lab tests, you can adjust your next refill before shipping.
Availability and Substitutions
Availability can vary by strength. If a strength is temporarily unavailable, your prescriber may suggest a different combination of tablets or a therapeutically equivalent brand. Do not change products without consulting your clinician and arranging appropriate TSH monitoring.
Patient Suitability and Cost Saving Tips
Synthroid may suit adults and children diagnosed with hypothyroidism, including after thyroid surgery or radioiodine. It may not suit those with untreated adrenal insufficiency or unstable cardiac disease until stabilized. People with lactose or dye sensitivities should discuss options and specific strengths.
To save on cost, consider 90-day supplies if appropriate for you. Align refills with lab schedules to avoid wasted tablets after a dose change. Keeping the same brand or manufacturer can reduce extra lab visits tied to switching products.
Questions to Ask Your Clinician
- What is my TSH target and monitoring schedule?
- Which dose should I start, and when will we recheck labs?
- How should I space Synthroid from calcium, iron, or antacids?
- Is bedtime dosing suitable for me?
- Should I stay with brand-name Synthroid or a specific generic?
- What signs suggest my dose is too high or too low?
- How might pregnancy or menopause change my dose needs?
Authoritative Sources
- FDA DailyMed: Levothyroxine Sodium Tablets
- Manufacturer Site: Synthroid
- Health Canada Drug Product Database
Start your order today for US delivery from Canada. This information is educational and not a substitute for professional medical advice.
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How should I take Synthroid in the morning?
Take it with water on an empty stomach, 30 to 60 minutes before breakfast. Avoid coffee, food, calcium, and iron until later to improve absorption.
Can I switch from generic levothyroxine to Synthroid?
Yes, but switching brands or manufacturers can affect TSH. If you switch, plan to recheck labs in 6 to 8 weeks and adjust the dose if needed.
How long before I feel better on Synthroid?
Many people notice improvements within a few weeks. TSH levels usually stabilize 6 to 8 weeks after a dose change, guiding further adjustments.
Is Synthroid used for weight loss?
No. Levothyroxine should not be used to treat obesity. Misuse can cause serious or life-threatening effects, especially with stimulants.
What interacts with Synthroid tablets?
Iron, calcium, antacids, sucralfate, and bile acid sequestrants reduce absorption. Rifampin, carbamazepine, phenytoin, and estrogen therapy can alter dose needs.
Is Synthroid safe in pregnancy and breastfeeding?
Yes. Treating hypothyroidism is important during pregnancy. Dose needs often rise; monitor TSH closely. Levothyroxine is compatible with breastfeeding.
Do I need a prescription to order Synthroid online?
Yes. A valid prescription is required. We verify it with your clinic before licensed Canadian pharmacies dispense your order and ship to the US.
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