Nesina vs Januvia

Nesina (alogliptin) and Januvia (sitagliptin) are prescription medications that lower blood sugar. Both medications are dipeptidyl peptidase-4 (DPP-4) inhibitors.

What are these medications used for?

Though there are differences between alogliptin and sitagliptin, they are both used to treat type 2 diabetes. They are ideal as add-on medications for patients having difficulty controlling their blood sugar levels. Though not as effective as insulin, Nesina and Januvia help to keep insulin levels stable. For the most effective results, Nesina and Januvia should be used in combination with a regulated diet and exercise.

How to take these drugs

Unlike many other diabetes medications, alogliptin and sitagliptin are taken as oral pills once daily instead of via injection. Each may be taken with or without food.

Nesina and Januvia side effects

While Nesina and Januvia are both safe and effective medications, patients may experience side effects. Patients experiencing severe side effects should contact a doctor immediately.

Common side effects

  • Upper respiratory tract infection
  • Nasopharyngitis
  • Headache

Severe side effects

  • Seizures
  • Blurred vision
  • Dizziness


When it comes to alogliptin vs sitagliptin, the biggest difference is the dosage. Though the instructions for taking the medications are the same, the dosage varies. The recommended dose of Nesina is 25 mg taken once daily, while the recommended dosage of Januvia is 100 mg taken once daily.


Disclaimer: Please note that the contents of this community article are strictly for informational purposes and should not be considered as medical advice. This article, and other community articles, are not written or reviewed for medical validity by Canadian Insulin or its staff. All views and opinions expressed by the contributing authors are not endorsed by Canadian Insulin. Always consult a medical professional for medical advice, diagnosis, and treatment.