Rybelsus Vs. Ozempic are two anti-diabetes medications. These FDA-approved medicines help control blood sugar levels in adults diagnosed with type 2 diabetes. Although Rybelsus and Ozempic share similar functions, they still have significant differences.


Rybelsus is an oral diabetes medicine that works best if combined with diet and exercise. It is typically prescribed if other diabetes treatments do not work for patients. This medicine helps improve glycemic control in adults with type 2 diabetes mellitus.

Unlike Rybelsus, Ozempic is an injectable medicine administered subcutaneously. Ozempic controls blood glucose levels. It is combines with the right diet and proper exercise. Besides diabetes, Ozempic also reduces the risk of cardiovascular diseases.


Rybelsus and Ozempic do not share the same forms regardless of their similar functions. Rybelsus is available as an oral tablet, while Ozempic is purchased as a pre-filled, disposable injection.

Standard dosage of Rybelsus:

  • Take one dose of 3 mg Rybelsus daily. This treatment will take 30 days.
  • The maximum dosage of Rybelsus is 14 mg per day.

Below is the standard dosage of Ozempic:

  • The initial dose for Ozempic is 0.25 mg, to be administered subcutaneously once a week.
  • The maximum dosage is 1 mg of injectable Ozempic per week.


Rybelsus and Ozempic are both branded versions of Semaglutide. In terms of their pricing, they are very similar. The average cost of 30 tablets of Ozempic is $948.84. Meanwhile, a 1.5 mL of Rybelsus also costs $948.84. Of course, the price of each medicine can still vary based on the prescription provided by the healthcare professional.

Side Effects

Despite sharing similar functions, Rybelsus and Ozempic have different side effects. These are as follows:


  • Low blood sugar
  • Upset stomach
  • Nausea
  • Vomiting
  • Lack of appetite
  • Diarrhea
  • Headache
  • Dizziness
  • Tiredness


  • Low blood sugar
  • Stomach pain
  • Pain at the injection site
  • Nausea
  • Vomiting
  • Constipation
  • Migraine
  • Drowsiness
  • Weakness