Unveiling the Mechanism: How Invokana Controls Blood Sugar Levels

Publish On Diabetes By CanadianInsulin

Invokana and blood sugar control

Invokana and blood sugar control. In March 2013, the Food and Drug Administration (FDA) approved Invokana (canagliflozin) tablets to manage type 2 diabetes in adults. Around 24 million Americans are affected by this type of diabetes, which can cause severe health problems like heart disease and kidney damage due to high blood sugar. In recent years, medical science has made significant strides in developing innovative treatments for various health conditions. Among these advancements is Invokana, a medication that primarily aids in managing blood sugar levels. Understanding how Invokana works to control blood sugar levels will provide valuable insights into its efficacy and potential benefits for patients.

Invokana In-Depth

Invokana, also known by its generic name canagliflozin, is a medication belonging to the class of drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. Its mechanism of action is distinct from other diabetes medications. It targets the SGLT2 protein in the kidneys. SGLT2 is responsible for reabsorbing glucose (sugar) from the urine into the bloodstream.

By inhibiting SGLT2, Invokana prevents glucose reabsorption, causing excess glucose secretion through urine. This results in lower blood sugar levels as the body expels the excess glucose rather than allowing it to accumulate in the bloodstream.

Key Benefits of Invokana 

The following includes the key benefits of Invokana as an effective diabetes medication:

Blood Sugar Reduction: 

The primary benefit of Invokana is its ability to lower blood sugar levels. The medication helps regulate blood sugar levels and reduce hyperglycemia by preventing glucose reabsorption in the kidneys.

Weight Loss: 

Invokana can also contribute to weight loss in people with type 2 diabetes. It works by causing the body to excrete more glucose through urine, which in turn leads to a reduction in calorie intake. As a result, some individuals may experience weight loss as a secondary effect of using Invokana to manage their diabetes. However, the extent of weight loss can vary among individuals.

Cardiovascular Protection: 

Invokana has demonstrated potential in offering cardiovascular protection alongside its role in managing type 2 diabetes. Several studies have suggested that it may reduce the risk of cardiovascular events, such as heart attacks and strokes. Although the exact mechanisms responsible for this cardiovascular benefit are not fully understood, experts believe it is related to the drug’s impact on blood sugar levels, blood pressure, and other factors. We need further research to gain a comprehensive understanding of how Invokana provides these cardiovascular benefits.

Kidney Benefits: 

Invokana, a medication that contains canagliflozin, has shown potential benefits for kidney health in individuals with type 2 diabetes. It works by inhibiting glucose reabsorption in the kidneys, increasing glucose excretion in the urine. This mechanism of action helps manage blood sugar levels and has potential benefits for the kidneys.

Several studies have indicated that Invokana can reduce the risk of kidney complications in individuals with type 2 diabetes. Studies have shown it reduces the risk of kidney failure and cardiovascular events. In fact, the Food and Drug Administration (FDA) recently approved Invokana to treat diabetes-related kidney disease and reduce the risk of hospitalization for heart failure.

Exploring Invokana Safety, Efficacy, and Real-World Results


Invokana, like any medication, comes with potential side effects. Common side effects may include urinary tract infections, increased urination, and thirst. However, more severe side effects have also been reported, such as:

  • Ketoacidosis: A severe condition where high levels of ketones build up in the blood. It can be life-threatening if not addressed immediately.
  • Genital Infections: SGLT2 inhibitors often cause an increased risk of genital yeast infections in both men and women.
  • Dehydration and Low Blood Pressure: Due to increased urination, there’s a risk of dehydration and low blood pressure.
  • Bone Fractures: Some studies have suggested a potentially increased chance of bone fractures, especially in women.


Invokana is usually combined with other diabetes medications or as part of a broader treatment plan that includes lifestyle changes. Clinical trials have showed its ability to lower HbA1c levels and improve glycemic control.

Real-World Results

Positive Outcomes: Many patients find that Invokana helps them achieve better blood sugar control, lose some weight because of glucose excretion, and reduce their dependence on other diabetes medications.

Challenges: Real-world data have also highlighted the importance of patient education and monitoring. As the medication increases urine glucose excretion, there’s an additional risk of urinary tract infections and genital infections. Additionally, the risk of dehydration should not be underestimated, especially in older adults or those with kidney problems. It’s worth noting that each person’s response to medication can vary, and what works well for one individual might not work the same way for another. Therefore, regular communication with a healthcare provider is crucial to monitor how the medication affects you and make any necessary adjustments to your treatment plan.