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Xultophy® Prefilled Pen

Xultophy® Prefilled Pen: Insulin + GLP-1 for Diabetes Care

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Managing type 2 diabetes is often a balancing act that involves careful monitoring, lifestyle adjustments, and effective medication. For many patients, finding a treatment that delivers strong blood sugar control without adding complexity to their daily routine is a top priority. The Xultophy prefilled pen offers a breakthrough solution by combining two proven diabetes medications: insulin and a GLP-1 receptor agonist in one simple, once-daily injection.

This article provides an overview of the medication’s mechanism, dosing guidelines, potential side effects, pricing, and safe options for purchasing.

What is Xultophy?

At its core, Xultophy is a fixed-ratio combination medication specifically developed for individuals with type 2 diabetes who require improved blood sugar management. The pen combines two active ingredients:

  • Insulin degludec, a long-acting insulin that provides a steady baseline insulin level to control blood glucose throughout the day and night.
  • Liraglutide, a GLP-1 receptor agonist that enhances the body’s own ability to regulate blood sugar by stimulating insulin release when needed, slowing digestion, and promoting satiety.

By merging these two treatments, Xultophy offers a comprehensive, dual-mechanism approach that can improve glycemic control more effectively than either therapy alone. This combination can also reduce the number of injections needed compared to taking insulin and GLP-1 therapies separately, simplifying your diabetes management.

How Does Xultophy Work?

The Xultophy insulin component mimics the natural, slow-release insulin your pancreas normally produces, helping to maintain steady blood sugar levels between meals and overnight. This basal insulin action reduces the risk of high blood sugar spikes.

Meanwhile, the liraglutide portion acts only when blood glucose levels rise, triggering more insulin release and minimizing the amount of sugar produced by the liver. It also delays the movement of food through the stomach, which helps control appetite and may aid in weight loss, a significant benefit for many people living with type 2 diabetes.

Together, these two components work synergistically to target different aspects of diabetes, making Xultophy a powerful tool for blood sugar control.

Understanding Xultophy Dosing

One of the key features of the Xultophy pen is its flexibility in dosing. Instead of measuring insulin and GLP-1 separately, dosing is given in “dose steps.” Each dose step contains a fixed ratio of insulin degludec and liraglutide, specifically, 1 unit of insulin degludec and 0.036 mg of liraglutide.

Typically, treatment starts with a low dose, often 10 dose steps once daily, which your healthcare provider will adjust gradually based on your blood sugar readings and treatment response. Dosing is personalized, so it’s critical to follow your provider’s instructions and attend regular check-ups for monitoring.

Because this medication contains liraglutide, your  Xultophy dosing may start low and increase slowly to lessen the risk of gastrointestinal side reactions like nausea.

What Are the Possible Side Effects of Xultophy?

As with any medication, Xultophy side effects may occur. It’s essential to be aware of the common and more severe potential reactions to ensure a safe treatment.

Common side effects include:

  • Nausea, vomiting, or diarrhea (especially when starting therapy or increasing dose)
  • Injection site reactions like inflammation, redness, swelling, or itching
  • Low blood sugar (hypoglycemia), especially if combined with other diabetes medicines
  • Headache or fatigue

Most side effects typically lessen and disappear as your body adjusts to the medication. However, if you experience severe symptoms such as persistent vomiting, allergic reactions (rash, swelling, difficulty breathing), or signs of pancreatitis (severe stomach pain), seek medical attention immediately.

Always inform your healthcare provider about any Xultophy side effects you experience so that they can adjust your treatment safely.

What to Expect from the Cost

When considering any medication, cost is an important factor. The Xultophy price can vary depending on your country, insurance coverage, and pharmacy. Because Xultophy combines two drugs in one, it is generally priced higher than individual diabetes medications.

If cost is a concern, some patients explore options to buy Xultophy from Canada or other countries where drug prices may be lower due to different pharmaceutical regulations. This can be a way to access the medication affordably, but it’s crucial to ensure you purchase from reputable and legal sources to avoid counterfeit or unsafe products.

Review your treatment options with your healthcare provider or pharmacist, who can assist you in finding financial assistance programs or advise on safe medication purchases. To explore more details or to buy, visit our Xultophy Prefilled Pen Product Page today.

Why Choose the Xultophy Prefilled Pen for Diabetes Care?

The Xultophy prefilled pen marks a significant advancement in managing type 2 diabetes by combining the benefits of long-acting insulin and GLP-1 receptor agonist therapy into a single, easy-to-use injection. This streamlined approach can simplify your treatment while providing effective blood sugar control.

Although the price of Xultophy may be higher than some alternatives, options such as purchasing from reputable international sources can help improve affordability. Always prioritize your safety by consulting with your healthcare provider and obtaining medications through trusted channels.

If you’re looking for a convenient, effective treatment option, discuss with your doctor whether the Xultophy pen is the right choice to support your diabetes management journey. 

Frequently Asked Questions (FAQs)

How is Xultophy different from taking insulin and GLP-1 therapies separately?

Xultophy combines insulin degludec and liraglutide in one prefilled pen, reducing the number of daily injections and simplifying dosing while providing effective blood sugar control through two complementary mechanisms.

Can I use the Xultophy pen if I have type 1 diabetes? 

No, Xultophy is specifically approved for individuals with type 2 diabetes and is not recommended for type 1 diabetes or for diabetic ketoacidosis treatment.

What are the storage requirements for the Xultophy prefilled pen?

Unopened Xultophy pens should be stored in the refrigerator at a temperature between 2°C and 8°C (36°F to 46°F). Once in use, the pen can be kept at room temperature (up to 30°C or 86°F) for up to 21 days. Always protect the pen from direct heat and light. 

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Written by CDI Staff Writer on June 5, 2025

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