Kazano (alogliptin and metformin HCl) tablets

Kazano is a prescription tablet that combines alogliptin and metformin for type 2 diabetes. This page summarizes dosing basics, safety considerations, storage, and access details, including Ships from Canada to US. It also explains what can affect Kazano price for cash-pay patients, including those without insurance.

What Kazano Is and How It Works (Kazano price)

This medicine contains two glucose-lowering ingredients: alogliptin (a DPP-4 inhibitor) and metformin (a biguanide). DPP-4 inhibitors raise levels of incretins (gut hormones that help regulate insulin and glucagon after meals). Metformin primarily lowers glucose made by the liver and improves insulin sensitivity (how well the body responds to insulin). Together, the combination targets both fasting and after-meal blood sugar.

Why it matters: Understanding each ingredient helps when reviewing warnings and lab monitoring.

Some people take this treatment after trying metformin alone, while others start it when a clinician wants two medicines in one tablet. It is not insulin, and it is not used for type 1 diabetes. Orders are dispensed by licensed Canadian pharmacies after required checks.

Who It’s For

This combination is indicated for type 2 diabetes in appropriate patients, typically alongside lifestyle measures such as nutrition planning and physical activity. It is not intended to treat diabetic ketoacidosis (a serious complication caused by very high ketones) or type 1 diabetes. For background on the condition, browse the Type 2 Diabetes hub or the broader Diabetes resource area.

Contraindications and “do not use” situations are based on the product labeling and clinical assessment. Metformin-containing products are generally avoided in severe kidney impairment or in acute conditions that can reduce kidney function. This therapy is also not used in patients with metabolic acidosis (including diabetic ketoacidosis). A clinician may use added caution in people with a history of pancreatitis, heart failure, liver disease, heavy alcohol intake, or older age, because these factors can change safety risks.

For related options, the Combination Tablets collection and Non Insulin Medications category can be browsed as product lists.

Dosage and Usage

Kazano is an oral tablet usually taken with meals to reduce gastrointestinal upset from metformin. Many regimens use twice-daily dosing, because metformin in this combination is immediate-release. The specific tablet strength and schedule depend on the patient’s current metformin dose, kidney function, and overall glucose plan. Prescribers may start at a lower metformin amount and adjust over time to improve tolerability.

Quick tip: If a dose is missed, follow the label directions rather than doubling up.

Swallow tablets as directed on the label. Some patients experience stomach upset early in therapy, which can improve after the body adapts. If symptoms persist, prescribers may reassess the regimen. When comparing refills across strengths or quantities, note that daily tablet count and strength can influence Kazano price in cash-pay situations.

Clinicians also consider situations where metformin may need temporary interruption, such as certain imaging procedures that use iodinated contrast or during acute illness that raises dehydration risk. Those decisions are individualized and should follow the official prescribing information.

Strengths and Forms

This product is supplied as an oral tablet that combines fixed doses of alogliptin with metformin hydrochloride (HCl). You may also see it described as alogliptin metformin tablets or alogliptin and metformin HCl. Tablet appearance and packaging can vary by manufacturer and dispensing pharmacy.

Commonly marketed strengths include alogliptin 12.5 mg paired with either metformin 500 mg or metformin 1000 mg. Not every strength is stocked at all times, and availability can change. Before comparing options, confirm the exact strength on the prescription and the dispensing label, since that is the reference point for tracking Kazano price accurately.

For broader context on non-insulin therapies, browse the Diabetes category of products and subcategories.

Storage and Travel Basics

Store tablets at room temperature and keep them protected from moisture and heat. Keep the container tightly closed and out of reach of children and pets. Avoid storing tablets in bathrooms or other humid spaces, because moisture can affect tablets over time.

For travel, carry the medication in its original labeled packaging. This helps with identification at security checkpoints and reduces the chance of mixing tablets with other medicines. Keeping the labeled package can also simplify reconciliation of receipts and Kazano price records across refills. If tablets look discolored, crumbling, or unusual, a pharmacist should be asked to review the product before use.

When organizing a trip, plan ahead for routine refills and keep a copy of the prescription details available. For practical background on the condition, the article Managing Type 2 Diabetes provides an overview of day-to-day considerations.

Side Effects and Safety

Common side effects can reflect either ingredient. Metformin frequently causes gastrointestinal symptoms such as nausea, diarrhea, stomach upset, or reduced appetite, especially when starting or increasing doses. Alogliptin may be associated with headache or upper-respiratory symptoms in some patients. Low blood sugar is more likely when this medicine is used with insulin or sulfonylureas, rather than by itself.

More serious risks are uncommon but important. Metformin carries a warning for lactic acidosis (a dangerous buildup of lactic acid), especially in settings such as significant kidney impairment, dehydration, severe infection, or heavy alcohol use. Alogliptin labeling includes warnings about pancreatitis and heart failure risk in some patients, and severe allergic reactions can occur with either ingredient. Prescription information may be verified with the prescriber when required.

Serious symptoms that need urgent evaluation

Patients should seek urgent medical care for symptoms consistent with lactic acidosis, such as unusual muscle pain, rapid breathing, severe weakness, increasing sleepiness, or abdominal discomfort that worsens. Sudden severe stomach pain that may radiate to the back, with or without vomiting, can be a sign of pancreatitis and needs prompt assessment. Swelling of the face or throat, hives, blistering rash, or difficulty breathing can indicate a serious hypersensitivity reaction. New or worsening shortness of breath, sudden weight gain, or leg swelling should be evaluated, especially in people with heart failure risk factors.

If side effects lead to switching therapies, clinicians may reassess both clinical fit and practical factors, including how that change could affect Kazano price over time. Routine monitoring often includes kidney function and blood glucose trends, and some patients may have vitamin B12 checked during longer-term metformin use.

Drug Interactions and Cautions

Interactions can involve both components. Alcohol can increase the risk of lactic acidosis with metformin and may also affect blood sugar. Certain medicines that affect kidney function, fluid balance, or blood glucose control can increase side effect risk or change effectiveness. Tell the prescriber about all prescription drugs, over-the-counter products, and supplements, including herbal products.

Metformin-specific cautions include iodinated contrast studies and conditions that can cause dehydration. Clinicians may recommend temporary interruption around selected procedures or acute illnesses, depending on kidney function and overall status. DPP-4 inhibitors are also used as single agents; for a focused review of alogliptin, see Nesina Uses And Dosage and the comparison guide Nesina Vs Januvia.

Compare With Alternatives

Clinicians often compare combination tablets based on ingredients, dosing frequency, kidney considerations, side-effect profile, and patient preference. One alternative approach is metformin alone (single-ingredient therapy), which is available in multiple formulations; see the product page for Metformin for reference. Another option is pairing metformin with a different DPP-4 inhibitor, such as sitagliptin/metformin (including extended-release forms).

For example, Janumet XR combines a different DPP-4 inhibitor with metformin in an extended-release format, which may change dosing patterns and gastrointestinal tolerability for some patients. Other combination categories use SGLT2 inhibitors with metformin (for example, combinations similar to Synjardy, Xigduo, or Invokamet), which have different warnings and urinary or volume-related side effects. For cash-pay comparisons, consider regimen fit and total out-of-pocket impact such as Kazano price, but keep clinical suitability as the primary driver.

For more background on sitagliptin/metformin combinations, the guide Janumet Explained Guide summarizes typical use patterns. For an SGLT2/metformin example, Synjardy Uses And Side Effects reviews major considerations and cautions.

Pricing and Access

Pricing for combination tablets can vary by strength, quantity, and dispensing pharmacy. Administrative steps can also affect the final total, such as whether additional documentation is needed to confirm a prescription. When reviewing Kazano price, match the quote to the exact strength and tablet count on the prescription to avoid comparing unlike items.

This service supports access through a prescription referral model rather than acting as the dispensing pharmacy. The process may include prescription upload and, when required, confirmation with the prescriber before a licensed Canadian pharmacy dispenses. Cash-pay access can help patients without insurance who are comparing non-insulin options.

Site users can review rotating non-price benefits on the Current Promotions page when available. For browsing similar therapies by class, use the Non Insulin Medications list or the Combination Tablets collection to compare ingredients and formats.

Authoritative Sources

For decisions about prescribing, monitoring, and contraindications, the official labeling and clinical guidelines are the most reliable references. The links below provide manufacturer labeling and diabetes care standards that clinicians commonly use.

• For the current U.S. labeling, see DailyMed.
• For diabetes education and standards updates, see the American Diabetes Association.

To request dispensing through the site, add the item to cart and follow prescription steps; some orders use prompt, express, cold-chain shipping.

This content is for informational purposes only and is not a substitute for professional medical advice.