NexGard® Combo Topical for Cats

What NexGard® Combo Is and How It Works

NexGard® Combo is a prescription spot-on solution for cats and kittens. It treats fleas and ticks, prevents heartworm disease, and addresses common intestinal worms. You can order NexGard Combo topical solution for cats from Canada, with US delivery from Canada and Canadian pricing. This helps many pet families who pay out of pocket or buy without insurance. At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

NexGard Combo contains three active ingredients: afoxolaner, eprinomectin, and praziquantel. Afoxolaner is an isoxazoline that targets flea and tick nervous systems. Eprinomectin is a macrocyclic lactone that prevents heartworm and treats certain roundworms and hookworms. Praziquantel targets tapeworms. Together, these agents provide broad parasite control in one monthly dose.

This feline formulation is applied to the skin, not given by mouth. Once absorbed, it provides systemic activity against fleas and ticks across the body. It prevents heartworm when given on a regular monthly schedule during mosquito season. It also treats intestinal parasites such as roundworms, hookworms, and tapeworms. Many veterinarians use NexGard Combo for cats with flea allergy dermatitis risk, because consistent flea control reduces allergen exposure.

Owners often choose NexGard Combo for cats that resist tablets. The simple spot-on design helps with adherence. It is a genuine NexGard Combo flea and tick for cats option that also covers worms, making it a practical all-in-one monthly plan.

Who NexGard® Combo Is For

This medicine is intended for domestic cats and kittens that need control of external and internal parasites. It may be suitable when a veterinarian recommends coverage for fleas, ticks, heartworm prevention, ear mites, roundworms, hookworms, and tapeworms.

• Cats and kittens old enough and heavy enough per label. Many markets allow use from 8 weeks of age and a minimum weight, often starting at 0.8 kg.
• Household cats that need monthly flea and tick prevention plus heartworm prevention.
• Cats with exposure to prey or outdoor environments where intestinal worms and ticks are common.

Who should avoid it:

• Kittens below the labeled age or weight threshold.
• Cats with a known sensitivity to isoxazolines or any component.
• Cats with a history of neurologic disorders should be assessed carefully by a veterinarian.
• Use in pregnant or lactating queens only if a veterinarian determines the benefit outweighs risk. Safety data may be limited.

If you only need flea, heartworm, and mite control without tick or tapeworm coverage, talk to your veterinarian about alternatives such as Revolution® For Cat. For very young kittens, your veterinarian can advise products appropriate for age and weight, including options like Revolution® For Puppies Kittens.

Dosage and Usage

NexGard Combo is a spot-on medicine used once a month. The pipette size is chosen based on the cat’s body weight. Part the hair and apply the full contents directly to the skin, typically at the base of the skull where the cat cannot lick. Use a single dose every month, on or around the same date. For heartworm prevention, continue monthly dosing during mosquito season and for a month after the final exposure, per veterinary advice.

Apply to clean, dry skin. Do not apply to wet fur. Avoid the eyes and mouth. Prevent grooming by other household pets until the application site is dry.

Strengths and Forms

NexGard Combo comes as single-use pipettes of topical solution for cats. Presentations generally align to weight bands. Availability may vary by market.

• Pipette for small cats, often starting from 0.8 to 2.5 kg.
• Pipette for medium cats, commonly 2.5 to 7.5 kg. Many listings describe this as NexGard Combo 2.5–7.5 kg cats.
• Heavier cats over 7.5 kg may require a combination of pipettes per veterinary guidance.

Product naming may note formats such as NexGard Combo 2.5 kg cats or NexGard Combo spot-on solution for cats. Exact strengths and volumes are specified on the labeled carton. Availability may vary.

Missed Dose and Timing

If a monthly dose is missed, apply when remembered and resume a monthly schedule. Keep doses about one month apart. If a prolonged gap occurs during heartworm season, consult the veterinarian. Testing may be recommended before restarting heartworm prevention in some situations.

Storage and Travel Basics

Store NexGard Combo in the original packaging at room temperature. Protect from moisture and excess heat. Keep out of reach of children and away from food preparation areas. Individual pipettes are sealed and portable, which helps with travel and holiday plans. When you travel with your pet, keep the carton or a copy of the prescription with your records.

Always wash hands after application. Prevent contact with the application site until dry. Keep used and unused pipettes away from household pets and small children. You can place your order with encrypted checkout and prompt, express shipping.

Benefits

• Broad monthly protection in one spot-on for cats, including fleas, ticks, and heartworm prevention.
• Treats common intestinal worms such as roundworms, hookworms, and tapeworms.
• Helps reduce the impact of flea allergy dermatitis by breaking the flea life cycle.
• Topical route helps cats that refuse tablets.
• Simple monthly schedule supports adherence for multi-pet homes.
• Designed as afoxolaner eprinomectin praziquantel spot-on with wide parasite coverage.

Side Effects and Safety

• Temporary application-site effects, such as hair loss, dandruff, redness, or mild irritation.
• Itching or grooming after application.
• Digestive signs, such as vomiting, soft stool, or reduced appetite.
• Lethargy or behavioral changes.
• Hypersalivation if the cat licks the wet site.

More serious effects are uncommon but possible. Isoxazolines have been associated, rarely, with neurologic signs such as tremors, ataxia, or seizures, even in animals without a known history. Severe allergic reactions can occur in rare cases. Do not use on kittens below the labeled age or weight. Do not use on rabbits. Keep the product away from the cat’s mouth and eyes. Contact a veterinarian promptly if concerning signs appear.

Drug Interactions and Cautions

• Do not combine with other isoxazoline products unless the veterinarian directs it.
• Avoid duplication with other macrocyclic lactones or tapeworm treatments unless prescribed.
• Use caution in cats with a history of seizures or neurologic disease.
• Apply only to intact skin and follow label technique to minimize ingestion.
• Discuss all medicines, supplements, and parasite preventives with the veterinarian before use.

What to Expect Over Time

Many cats experience relief from flea activity shortly after application. Regular monthly use helps break the flea life cycle in the home environment. Tick control is maintained through the monthly interval. When used on schedule during mosquito season, heartworm prevention is maintained. Intestinal worm treatment is achieved with each labeled dose, and reinfection risk depends on exposure. Most households plan monthly dosing year-round or seasonally, based on local risk and veterinary guidance.

Compare With Alternatives

Several veterinary options cover similar parasites. For a broad monthly topical that also covers ticks, veterinarians often consider Revolution® Plus. For a focused intestinal dewormer that treats roundworms, hookworms, and tapeworms without flea or tick control, a topical option is Profender®. Some veterinarians also use single-ingredient praziquantel products for tapeworm-only needs; see our guide on Droncit For Cats for context.

Pricing and Access

See NexGard Combo price for cats with Canadian pricing and US shipping. You can compare cost across weight bands before checkout. Many pet owners use a NexGard Combo cash price approach and self-pay for refills. If you want to track current offers, you can check our site promotions. You can place an order online with US shipping from Canada for genuine NexGard Combo for cats.

Browse more pet options in our Pet Medications category to compare coverage and formats.

Availability and Substitutions

Availability can vary by strength and pack size. If a specific pipette size is out of stock, a veterinarian may recommend an alternative that fits your cat’s weight and risk profile. Substitutions should only be made under veterinary direction to ensure parasites are covered appropriately.

Patient Suitability and Cost Saving Tips

Cats that spend time outdoors or hunt are often candidates for broad-spectrum control. Indoor cats can still encounter mosquitoes and fleas, especially in multi-unit buildings or during travel. Cats with a seizure history or very young kittens may need a different plan. Your veterinarian will tailor the choice to age, weight, and medical history.

• Ask about multi-month supplies to reduce per-order costs.
• Set calendar reminders for monthly application.
• Keep your cat’s weight current to ensure the right pipette size.
• If your household does not need tick or tapeworm coverage, a narrower product may reduce cost.
• For kittens, confirm the labeled starting age and weight before purchase.

Questions to Ask Your Clinician

• Is NexGard Combo the right choice for my cat’s flea, tick, and heartworm risks?
• What weight band should I use today, and when should I recheck weight?
• How should I coordinate deworming for tapeworms and other intestinal parasites?
• Are there concerns with my cat’s medical history, including any neurologic issues?
• What is the best monthly schedule for our region’s mosquito and tick seasons?
• What should I do if my cat grooms the application site before it dries?

Authoritative Sources

• EMA NexGard Combo EPAR
• Health Canada Drug Product Database

Order online with US delivery from Canada using prompt, express shipping.