Revolution® Topical for Cats

Revolution® for Cat is a prescription topical solution with selamectin that helps protect cats against fleas, ear mites, roundworms, hookworms, and heartworm disease. This once-monthly spot-on suits indoor and outdoor cats alike and is applied to the skin at the base of the neck. With US delivery from Canada and access to Canadian pricing, many households find it a practical, veterinary-standard option for parasite control.

What Revolution® Is and How It Works

Revolution® contains selamectin, a macrocyclic lactone that targets parasites’ nerve and muscle function, leading to paralysis and death. After application to the skin, it spreads across the coat and is absorbed systemically. The result is broad-spectrum protection: it kills adult fleas, prevents flea infestations, treats ear mites, prevents heartworm disease by targeting tissue-stage larvae, and treats and controls certain intestinal worms in cats. It does not cover ticks; cat owners seeking tick coverage typically consider combination products such as revolution plus or nexgard combo where appropriate.

CanadianInsulin connects patients with licensed Canadian pharmacies. Prescriptions are verified with your clinic before dispensing.

The medicine is applied once monthly. Each dose provides continuous coverage for the labeled parasites until the next application. In multi-pet homes, each pet usually needs its own species-appropriate preventive plan; for dogs in the household, see revolution for dog.

Who Revolution® Is For

Revolution is indicated for cats eight weeks of age and older for the prevention and control of the parasites listed on the label. Healthy adult cats and kittens old enough for the product are typical candidates. The product is generally considered safe for breeding, pregnant, and lactating queens when used as directed.

It should be used with caution in debilitated or underweight cats, and in cats with a history of hypersensitivity to selamectin or other avermectins/macrocyclic lactones. Do not use on kittens younger than the labeled age. If a kitten is below the labeled age or weight for standard pack sizes, discuss timing and alternatives with a veterinarian; some households use starter formulations such as revolution for puppies kittens under veterinary guidance.

Dosage and Usage

Revolution is dosed by your cat’s body weight. Use only the cat-specific product and the tube strength that matches the weight category on the carton. Apply to clean, dry skin at the base of the neck, between the shoulder blades.

Typical steps:

1. Weigh the cat to confirm the correct tube strength.
2. Open the single-use tube as shown on the package insert.
3. Part the hair until skin is visible. Touch the tube tip to the skin and empty the entire contents in one spot.
4. Do not rub the site. Allow to dry fully. Prevent other pets from licking the area until it is dry.
5. Wash hands after application and keep the tube away from children and other animals.

Apply once every month. Treat all pets as recommended by the veterinarian to control environmental parasite pressure. Do not use the dog product on cats, and do not split tubes between multiple animals.

If additional deworming is required for tapeworms, a veterinarian may recommend a complementary product; for example, see the article on droncit tapeworm treatment for general background.

Strengths and Forms

Revolution for cats is supplied as single-use topical tubes in weight-based strengths. Common cat presentations include tubes delivering 15 mg or 45 mg selamectin per application, with a fixed volume per tube. Cats above the highest labeled weight band are typically treated using an appropriate combination of tubes as directed by a veterinarian. Availability can vary by supplier and country of origin.

Missed Dose and Timing

If a monthly dose is missed, administer as soon as remembered and resume the normal monthly schedule. Do not apply two doses at once. Long gaps can reduce protection, including heartworm prevention, so a veterinarian may advise retesting or additional measures if dosing has been delayed for an extended period.

Storage and Travel Basics

Store Revolution in the original packaging at room temperature, in a dry place away from direct sunlight. The solution is flammable; keep away from heat sources and open flames. Do not freeze. Keep out of reach of children and animals.

When traveling, keep the unopened tubes in a sealable pouch within a carry-on bag, along with a copy of the prescription. Avoid leaving the product in a hot car. If needed, pack it with other medicines to streamline customs documentation for US delivery from Canada.

Benefits

For many households, a single monthly application that covers multiple parasite risks is the main advantage. Revolution kills adult fleas and helps break the flea life cycle, treats ear mites that cause itchy, inflamed ears, prevents heartworm disease, and treats and controls roundworms and hookworms listed on the label. Because it is a topical, there is no need to give tablets to cats that resist oral dosing.

Veterinarians often recommend consistent, year-round parasite control to protect cats that live indoors, outdoors, or in mixed environments. For broader parasite options across species and needs, browse pet medications.

Side Effects and Safety

Most cats tolerate Revolution well. Mild, transient effects can occur, typically at the application site or related to grooming after application. Commonly reported effects include:

• Temporary hair loss, flaking, or redness at the application site
• Itching or mild skin irritation
• Drooling or lip-smacking if the product is licked before it dries
• Decreased appetite, soft stool, or vomiting
• Lethargy or restlessness for a short period

Serious adverse reactions are uncommon but may include neurologic signs such as tremors, incoordination, or seizures, especially if the product is misapplied, ingested in significant amounts, or used in an animal with underlying sensitivity. Seek veterinary care urgently if severe or unusual symptoms occur. Avoid contact with the cat’s eyes or mouth. Prevent other animals from licking the application site until fully dry.

Drug Interactions and Cautions

Selamectin has a wide safety margin when used as labeled. Nonetheless, caution is advised if combining multiple topical ectoparasiticides or macrocyclic lactones. Discuss all current medicines, supplements, and topical products with a veterinarian, including antibiotics such as those discussed in our articles on clavamox antibiotic and cephalexin guide. Do not apply to broken skin. Keep cats separated after dosing if mutual grooming is likely. If treating concurrent ear infections, follow the veterinarian’s ear-cleaning and medication plan to avoid washing away the mite treatment before it absorbs.

What to Expect Over Time

Flea-killing activity begins after application and persists throughout the month. In flea-heavy environments, additional environmental control may be needed to fully clear the home. Ear mites often improve within days, with continued relief through the dosing interval. Heartworm prevention is maintained with on-time monthly doses. Many cats remain comfortable with a consistent routine, and households often see fewer parasite-related skin and ear issues over the long term.

Compare With Alternatives

For cats that need flea, ear mite, intestinal worm, and heartworm coverage without tick protection, Revolution is a well-established choice. When tick coverage is also needed, veterinarians may consider revolution plus. Another broad-spectrum topical for cats is nexgard combo, which includes components targeting fleas, ticks, heartworm larvae, and certain intestinal worms. For stand-alone intestinal deworming, some clinicians use products like profender as part of a tailored plan.

Pricing and Access

Ordering through CanadianInsulin provides access to Canadian pricing with US delivery from Canada. Add Revolution to the cart, upload a valid prescription, and we will coordinate dispensing through licensed Canadian pharmacies. Expect prompt, express, cold-chain shipping for medicinal items as appropriate. Checkout and customer data are protected by encrypted transfer.

To see current offers, visit our promotions page. Prices can vary by strength, pack size, and source pharmacy.

Availability and Substitutions

Supply can vary. If this item is unavailable, a prescriber may recommend a clinically suitable alternative for the same indications. Depending on the need, options might include revolution plus for added tick protection or nexgard combo as another comprehensive topical.

Patient Suitability and Cost-Saving Tips

Good candidates are cats eight weeks and older, in overall good health, and at risk of fleas, ear mites, intestinal worms, or heartworm exposure. Cats with severe skin disease at the application site or a past reaction to selamectin may need an alternative. Kittens must meet the labeled age and weight criteria. A multi-month supply can be a convenient way to maintain on-time dosing and may reduce per-dose costs. Refill reminders help keep protection uninterrupted. When ordering, consider combining eligible pet items within one shipment to optimize shipping value.

Questions to Ask Your Clinician

• Is Revolution the best fit for this cat’s lifestyle and local parasite risks?
• Does this cat also need tick protection, and if so, which product is preferred?
• How should ear cleaning be timed relative to application when treating ear mites?
• What signs of skin irritation or systemic reaction warrant a clinic visit?
• How long should parasite prevention continue after moving to a new home or season?
• What deworming plan is recommended if tapeworms are suspected?
• Is combining Revolution with other topical or oral preventives appropriate for this cat?

Authoritative Sources

Zoetis Revolution prescribing information

FDA CVM FOI summary for selamectin

Merck Vet Manual antiparasitic overview

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Disclaimer: This overview is informational and not a substitute for veterinary advice. Always follow the prescribing veterinarian’s instructions and the product label.