Enbrel® SureClick Auto-Injector for Rheumatoid and Psoriatic Disease

Enbrel® SureClick is a prefilled etanercept auto-injector used to manage certain autoimmune diseases in adults and children. CanadianInsulin offers the Enbrel Pre-Filled Sureclick Auto Injector from Canada with US delivery from Canada, helping you compare Canadian pricing if you pay without insurance. This guide explains how it works, who it is for, dosing, handling, storage, and important safety details.

What Enbrel® Is and How It Works

Enbrel® contains etanercept, a tumor necrosis factor (TNF) blocker. TNF is a protein that can drive inflammation in conditions like rheumatoid arthritis and plaque psoriasis. By binding to TNF, etanercept helps reduce inflammatory activity in joints, skin, and related tissues. Enbrel treatment is intended to relieve symptoms such as pain and stiffness, improve function, and help control skin plaques in eligible patients.

CanadianInsulin is a prescription referral service. We verify your prescription with your clinic, and licensed Canadian pharmacies dispense your order. Orders are shipped from Canada to the US.

Enbrel SureClick is a single-dose, prefilled auto-injector designed for subcutaneous use. Many adults use a 50 mg weekly schedule. Children with certain conditions use weight-based dosing as directed by their specialist.

Who Enbrel® Is For

Indications vary by country. Enbrel is commonly prescribed for:

• Moderate to severe rheumatoid arthritis in adults, alone or with methotrexate
• Psoriatic arthritis in adults
• Ankylosing spondylitis in adults
• Moderate to severe chronic plaque psoriasis in adults who are candidates for systemic therapy or phototherapy
• Polyarticular juvenile idiopathic arthritis in eligible pediatric patients

Learn more about these conditions in our categories for Rheumatoid Arthritis and Plaque Psoriasis.

Who should not use Enbrel: people with sepsis should not start Enbrel. It is not suitable for patients with active serious infections. Your clinician may evaluate you for tuberculosis and hepatitis B, and review your history of recurrent infections, demyelinating disease, or heart failure before starting therapy.

Dosage and Usage

General, widely published schedules include:

• Rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: 50 mg once weekly subcutaneously
• Plaque psoriasis: some adults start with 50 mg twice weekly for 3 months, then 50 mg once weekly thereafter
• Polyarticular juvenile idiopathic arthritis: weight-based dosing, often 0.8 mg/kg once weekly up to 50 mg maximum

Follow your exact prescription and local labeling. Your clinician will confirm the schedule, injection training, and monitoring plan. Do not change your dose on your own.

Strengths and Forms

Common presentations include the following. Availability can vary by market and by dispensing pharmacy.

• Enbrel SureClick 50 mg/mL Auto-Injector
• Enbrel SureClick Auto-Injector 50 mg 0.98 mL
• Enbrel Prefilled Auto-Injector 50 mg
• Enbrel Prefilled Syringe 50 mg/mL
• Etanercept 50 mg autoinjector
• Etanercept SureClick 50 mg/mL autoinjector
• Etanercept injection 50 mg/mL pen
• Enbrel 25 mg Prefilled Syringe
• Enbrel 25 mg Dose Pack

The Enbrel SureClick Pen 50 mg is designed for once-weekly use in many adult indications. Your pharmacist will dispense the labeled strength that matches your prescription.

Missed Dose and Timing

If you miss a weekly dose, inject as soon as you remember unless the next dose is due shortly. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once. Try to keep a consistent dosing day each week.

Storage and Travel Basics

Store Enbrel SureClick in a refrigerator at 2°C to 8°C. Keep it in the original carton to protect from light. Do not freeze. Do not shake. For short-term needs, the autoinjector may be kept at room temperature up to the period stated in the official labeling, commonly up to 14 days at or below 25°C. Do not return it to the refrigerator once it has been warmed to room temperature.

When traveling, carry your medicine with you in an insulated bag if needed. Keep it with your carry-on, not in checked luggage. Allow the pen to reach room temperature before injecting. CanadianInsulin uses prompt, express, cold-chain shipping to help maintain product integrity during transit.

Pen Handling and Sharps Disposal

General self-injection steps for the SureClick device:

• Gather supplies and wash your hands. Check the carton and expiration date.
• Let the pen warm to room temperature on its own. Do not use external heat.
• Inspect the solution. It should be clear to slightly opalescent, colorless to pale yellow, without particles.
• Choose an injection site on the front thigh, abdomen away from the navel area, or outer upper arm if someone else is giving the injection. Rotate sites with each dose.
• Clean the skin with an alcohol swab and let it dry.
• Remove the needle cap just before use. Place the pen at a 90-degree angle on the skin.
• Press and hold the device to start the injection. You may hear a click. Keep the pen in place until the indicator shows the dose is complete as directed in the device instructions.
• Remove the pen and apply gentle pressure with a cotton ball if needed. Do not rub.
• Dispose of the used device in an FDA-cleared sharps container. Do not throw it in household trash or recycling.

Review the Instructions for Use that come with your product, and ask your care team for training before your first self-injection.

Benefits

On-label benefits include reduced signs and symptoms of inflammatory disease, improved physical function, and, for some patients with rheumatoid arthritis, slowing of structural damage as described in the label. The Enbrel 50 mg weekly autoinjector schedule can be convenient. The prefilled device avoids the need to draw up doses and supports at-home administration after training.

Side Effects and Safety

Common side effects include:

• Injection site redness, itching, pain, or swelling
• Upper respiratory infections, sinus symptoms, cough, or sore throat
• Headache, dizziness, or fatigue
• Rash or mild gastrointestinal symptoms

Serious risks include severe infections such as tuberculosis, bacterial, or invasive fungal infections, which can require hospitalization. Lymphoma and other malignancies have been reported with TNF blockers. Rare events include demyelinating disorders, heart failure worsening, low blood counts, hepatitis B reactivation, serious allergic reactions, and lupus-like reactions. Seek urgent care if you develop high fever, persistent cough, shortness of breath, unexplained weight loss, night sweats, severe bruising, paleness, or signs of a severe allergic reaction.

Tell your clinician about all medical conditions, recent or chronic infections, exposures to TB, vaccination history, neurologic symptoms, and any heart problems. Review all medicines, vitamins, and supplements before starting therapy.

Drug Interactions and Cautions

• Vaccines: Avoid live vaccines during treatment. Inactivated vaccines may be given, but discuss timing with your clinician.
• Other biologics: Do not combine with anakinra or abatacept due to higher infection risk. Combining with other biologic immunomodulators is generally not recommended.
• Immunosuppressants: Your clinician will assess methotrexate and other therapies used with Enbrel for your condition.
• Infections and screening: Testing for latent tuberculosis and hepatitis B is commonly performed before treatment.

Read the full prescribing information for a complete list of warnings, precautions, and interactions.

What to Expect Over Time

Response is individual. Some people notice easing of joint pain, stiffness, or skin plaques within weeks, while others may require more time. Your clinician will check your progress and adjust your care plan if needed. Consistent weekly dosing and follow-up appointments help maintain benefit and safety. For more background on therapy expectations, see our editorial overview Enbrel Etanercept Guide.

Compare With Alternatives

Enbrel is one of several biologic options for rheumatic and psoriatic diseases. Another TNF blocker is Humira®. An IL-12/23 inhibitor alternative is Stelara® Pre Filled Syringe. Other options your clinician may consider include adalimumab biosimilars, IL-17 inhibitors such as ixekizumab or secukinumab, and IL-23 inhibitors like risankizumab. For a safety-focused overview across classes, you can review our article Ustekinumab vs Adalimumab.

Pricing and Access

You can buy Enbrel SureClick Auto-Injector online with Canadian pricing and US shipping through CanadianInsulin. See current pricing and place your order with encrypted checkout. We coordinate prescription verification with your clinic, then your medicine ships from licensed Canadian pharmacies with prompt, express, cold-chain shipping to the US where required. For current deals, visit our Promotions page.

Availability and Substitutions

Availability can vary by strength and form. If a specific presentation like Enbrel SureClick 50 mg/mL Auto-Injector or Enbrel Prefilled Syringe 50 mg/mL is temporarily unavailable, your prescriber may recommend an appropriate alternative or a different presentation. Always follow professional guidance when switching forms or brands.

Patient Suitability and Cost Saving Tips

Good candidates are patients with an approved diagnosis who have been evaluated for infection risks and vaccine status, and who can follow injection and monitoring plans. Patients with active serious infection, sepsis, or certain neurologic or cardiac conditions may not be candidates.

• Discuss multi-month quantities with your clinician and pharmacist to reduce per-shipment costs.
• Set refill reminders so you never miss a weekly dose.
• Keep your delivery address steady and store your supply properly upon arrival.
• If you change insurance or prescribers, ensure continuity of documentation to avoid delays.

Questions to Ask Your Clinician

• What screening tests do I need before starting Enbrel, such as TB or hepatitis B?
• Is Enbrel appropriate with my current medicines, including methotrexate or steroids?
• Which dose and schedule should I follow, and for how long?
• Which vaccines should I receive before treatment, and which should I avoid during therapy?
• What symptoms should prompt me to hold a dose and contact the clinic?
• How should I store my pens when traveling, and how long can they be at room temperature?
• What labs or follow-up visits will I need over time?

Authoritative Sources

• Amgen Prescribing Info
• FDA DailyMed
• Health Canada DPD

Ready to proceed? Start your order for Enbrel SureClick with prompt, express, cold-chain shipping from Canada to the US.