Enbrel® SureClick Auto Injector

Enbrel® (etanercept) is a TNF inhibitor used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, and certain juvenile arthritides. The SureClick pre‑filled auto injector delivers a measured subcutaneous dose with a hidden needle and simple activation. Available for US delivery from Canada, it supports patients seeking predictable access through a cross‑border service. Many cash‑pay customers, including those without insurance, choose Canadian pricing to help reduce out‑of‑pocket costs while staying with the original brand medication.

CanadianInsulin is a prescription referral service. We verify your prescription with your clinic, and licensed Canadian pharmacies dispense your order.

What Enbrel® Is and How It Works

Enbrel® is a biologic medicine that targets tumor necrosis factor (TNF), a key signaling protein that drives inflammation. It is a dimeric fusion protein that binds soluble TNF and blocks interaction with cell surface TNF receptors. By neutralizing excess TNF, Enbrel helps reduce synovial inflammation, ease pain and stiffness, and limit ongoing joint or skin damage. The SureClick auto injector is designed for self‑administration after training, with an ergonomic grip and an internal needle that activates with a single button press. Affordability options can be helpful for those paying without insurance.

Because Enbrel suppresses part of the immune response, clinicians commonly screen for tuberculosis and hepatitis B before starting therapy and monitor for infections during treatment. Live vaccines are generally avoided while receiving Enbrel unless a clinician determines otherwise.

Who Enbrel® Is For

Approved uses include adults with moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and chronic plaque psoriasis, plus certain children with polyarticular juvenile idiopathic arthritis and pediatric plaque psoriasis. To learn about each condition, see our resources on Rheumatoid Arthritis, Psoriatic Arthritis, and Plaque Psoriasis.

Enbrel is not appropriate during active, serious infections or sepsis. Clinicians use caution in patients with chronic or recurrent infections, poorly controlled diabetes, moderate to severe heart failure, demyelinating diseases (such as multiple sclerosis), or a history of certain cancers. Baseline screening for TB and hepatitis B is standard. Discuss potential pregnancy or breastfeeding plans with a clinician to weigh benefits and risks.

Dosage and Usage

Enbrel is given by subcutaneous injection using the SureClick auto injector or another presentation as prescribed. For adults with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, the usual regimen is a once‑weekly dose. Moderate to severe plaque psoriasis in adults may begin with a higher induction schedule followed by a weekly maintenance dose. In children with eligible diagnoses, dosing is weight‑based up to a maximum weekly amount. Follow the specific dosing plan provided by your prescriber.

General steps for the SureClick device: allow the injector to reach room temperature as directed on the label, check the solution visually (clear to slightly yellow, no particles), choose an injection site on the thigh, abdomen, or outer upper arm (if someone else is injecting), clean the skin, place the device firmly against the skin, and press the button to start the injection. Keep the device in place until the window indicator shows completion, then remove and dispose of the single‑use injector in a sharps container. Rotate injection sites to reduce local reactions.

Strengths and Forms

Common presentations include:

• SureClick auto injector: 50 mg/mL single‑use device
• Pre‑filled syringe: adult and pediatric concentrations available
• Other formats may be available in select markets

Availability can vary by pharmacy and market. If a different presentation suits injection training or dosing needs, consider the Enbrel Pre Filled Syringe option after discussing with your prescriber.

Missed Dose and Timing

If a dose is missed, administer it when remembered unless the next scheduled dose is very soon. If it is close to the next scheduled dose, skip the missed dose and resume the regular schedule. Do not take extra doses to compensate for a missed dose. Keep a personal dosing calendar or reminder to support steady weekly use.

Storage and Travel Basics

Store Enbrel in the refrigerator in its original carton to protect it from light. Do not freeze or shake. When needed, many labeled presentations can be kept at room temperature for a limited, one‑time period as described in the official instructions; once stored at room temperature, do not return the product to the refrigerator. Keep away from heat sources and direct sunlight. For travel, carry the medicine in an insulated bag with cold packs, but avoid direct ice contact. Keep it with your carry‑on to protect from extreme temperatures and pressure changes, and bring the pharmacy label or a copy of the prescription for security checks. Temperature‑sensitive items ship with cold‑chain handling and insulated packaging.

Pen Handling and Sharps Disposal

The SureClick auto injector is single‑use. Do not share the device. After each injection, place the used auto injector directly into an FDA‑cleared sharps container. If a specialized container is not available, a heavy‑duty, puncture‑resistant household container with a tight‑fitting, puncture‑proof lid can be used temporarily. When the container is about three‑quarters full, follow local regulations for disposal. Keep all injectors and sharps containers out of reach of children and pets.

Benefits

When used as prescribed, Enbrel reduces inflammatory activity that contributes to joint pain, stiffness, swelling, and skin plaques. Many patients experience improved physical function, fewer morning symptoms, and fewer joint flares. For plaque psoriasis, reduced redness and thickness of plaques can improve comfort and appearance. Early and consistent treatment may help slow progression of structural joint damage. Benefits vary by individual and condition, and regular clinician follow‑up helps ensure the regimen remains appropriate.

Side Effects and Safety

• Common: injection site redness, itching, pain, or bruising
• Upper respiratory infections, sinusitis, cough, headache
• Nausea, fatigue, dizziness, rash

Serious risks include opportunistic and serious infections (including TB), invasive fungal infections, hepatitis B reactivation, blood count changes, hypersensitivity reactions, demyelinating disease, lupus‑like syndrome, and new or worsening congestive heart failure. Certain cancers have been reported rarely with immunosuppressive therapies. Seek urgent care for signs of a severe allergic reaction such as widespread hives, trouble breathing, or facial swelling. Report persistent fever, weight loss, night sweats, or unusual bruising promptly.

Drug Interactions and Cautions

Do not use Enbrel with other biologic immunomodulators such as anakinra or abatacept unless a specialist directs otherwise. Combining with cyclophosphamide has been associated with adverse outcomes. Live vaccines are typically avoided during treatment and for a time after stopping. Before initiating therapy, clinicians often update inactivated vaccines. Tell your clinician about all prescription drugs, over‑the‑counter medicines, vitamins, and herbal supplements. Baseline screening for TB and hepatitis B is standard practice. Regular labs may be used to monitor blood counts or liver function as clinically indicated.

What to Expect Over Time

Anti‑TNF therapy effects build with steady dosing. Many patients notice improved joint comfort and function with sustained weekly use, and those with psoriasis may see gradual skin clearing. The goal is durable control of symptoms and reduced flares. If response is insufficient, clinicians may adjust background therapy or discuss alternate biologics with a different mechanism.

Compare With Alternatives

Other biologic options target TNF or different immune pathways. For TNF inhibition given by self‑injection, a common alternative is Humira. Agents that target IL‑17A or IL‑23 are options for psoriatic disease, such as Cosentyx or Taltz. Choice depends on diagnosis, comorbidities, prior therapies, and prescriber guidance. Switching between mechanisms is common when goals are not met.

Pricing and Access

US delivery from Canada can offer meaningful savings compared with typical cash‑pay prices at local pharmacies. To view current Canadian pricing and place an order, add the medicine to your cart and upload a valid prescription. Our team confirms details with your clinic before dispensing. If you are looking for seasonal offers, see our Promotions page. Orders ship with prompt, express, cold‑chain shipping when temperature control is required.

Availability and Substitutions

Product availability can vary. If a specific presentation is temporarily unavailable, a prescriber may recommend a clinically suitable alternative or a different Enbrel format such as the Enbrel Pre Filled Syringe. Therapy changes should be directed by the prescriber.

Patient Suitability and Cost‑Saving Tips

Good candidates include adults and children with eligible autoimmune diagnoses who have ongoing inflammation despite non‑biologic therapies, or those needing disease‑modifying treatment per guidelines. Patients with active infections, untreated latent TB, sepsis, or significant uncontrolled heart failure are generally not candidates. Those with a history of demyelinating disease need individual risk assessment.

Cost‑saving ideas: consider multi‑month supplies when clinically appropriate; consolidate items in a single shipment; schedule refills before travel so you can receive and store the medicine properly; and review manufacturer assistance or insurer options with your clinician or pharmacist. Keep notification reminders so reorders align with your dosing calendar.

Questions to Ask Your Clinician

• Which diagnosis and treatment goal does Enbrel address for me?
• What baseline tests (TB, hepatitis B, labs) should be completed before starting?
• How does the weekly dose fit with my other medicines or methotrexate?
• What is the plan for vaccines while I am on therapy?
• What signs of infection or side effects should prompt a call or visit?
• Could a different biologic mechanism be better for my situation if response is limited?
• How should I time injections around travel or procedures?
• What follow‑up schedule and labs will we use to monitor progress?

Authoritative Sources

Amgen Enbrel Prescribing InformationFDA: Enbrel (etanercept)American College of Rheumatology: Enbrel

Ready to proceed? Submit your prescription and place your order for Enbrel with prompt, express, cold‑chain shipping. US delivery from Canada is available through our licensed‑pharmacy network.

Disclaimer: This information is educational and does not replace the advice of a licensed clinician. Always follow the prescribing information and your clinician’s directions for diagnosis, treatment, and monitoring.