Humalog Mix® Cartridges for Adults with Diabetes

This premixed insulin comes in 3 mL cartridges for mealtime and between-meal coverage. You can review options, ratios, and refill steps with US delivery from Canada. We also outline ways to pay without insurance and get cartridge specifics.

What Humalog Mix Is and How It Works

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

Humalog Mix® combines a rapid-acting insulin lispro solution with an intermediate component formed by insulin lispro protamine suspension. Insulin lispro protamine and insulin lispro cartridges provide both components in one pen-ready format. The rapid part helps cover post-meal glucose rises, while the protamine fraction extends activity between doses. This medicine is for subcutaneous administration only; it is not for pumps or for intravenous use. Roll gently to resuspend until uniformly cloudy before each injection.

If you want a deeper overview of premixed analogs, see Premixed Insulin.

Who It’s For

This treatment is indicated to improve glycemic control in adults with diabetes mellitus. People who prefer a fixed-ratio premix that covers meals and between-meal needs may be candidates. Insulin lispro mix 75/25 cartridges are often chosen when a two-dose schedule aligns with daily meals. Those with highly variable meal timing or intensive titration needs may require different regimens. It should not be used to treat diabetic ketoacidosis.

Learn more about the condition at Diabetes.

Dosage and Usage

Use exactly as prescribed by your clinician. Typical patterns involve twice-daily injections given near meals. Inject subcutaneously into recommended areas and rotate sites to reduce skin changes. Gently roll the pen between your palms until the suspension looks uniformly cloudy; avoid vigorous shaking. Use U-100 cartridges only with compatible reusable pens and new pen needles for each dose. Do not share pens or needles.

For device technique, see our step-by-step Insulin Pen Guide. Follow the official label for detailed directions and safety information.

Strengths and Forms

Cartridges are supplied in fixed-ratio premixes and standard pack sizes. Availability can vary by market and stock status.

• Humalog Mix cartridges 3 mL
• Pack option: 5 x 3 mL
• Ratios: 75/25 and 50/50 premixed insulin lispro products
• Concentration: 100 units/mL
• For use with compatible reusable insulin pens

Missed Dose and Timing

If you miss a dose, check your blood glucose and take the dose with food when it is safe to do so. If it is close to the next scheduled injection, skip the missed dose to avoid stacking. Do not double doses. Contact your healthcare professional after any significant low blood sugar or persistent highs for individualized guidance.

Storage and Travel Basics

Before first use, keep cartridges refrigerated and protected from light. Do not freeze; discard any that have been frozen. After first use, keep the in‑use pen at room temperature within the limits stated on the official label. Avoid heat sources and direct sunlight. When traveling, carry spare cartridges and pen needles, store them in your carry‑on, and bring a copy of your prescription.

Our supply chain uses temperature-controlled handling when required. For general handling across pen supplies, see the Insulin Cartridges category.

Pen Handling and Sharps Disposal

Use a compatible reusable pen as directed by the manufacturer. Always attach a new sterile needle for each injection and never share pens or needles.

• Prime the pen with a small test dose per the pen’s manual
• Gently roll until the suspension is uniformly cloudy
• Dial the prescribed units carefully
• Inject subcutaneously and count to complete delivery
• Remove the needle and dispose in a sharps container
• Store the pen without a needle attached between doses

Benefits

This premixed regimen pairs a rapid component for meals with an intermediate component for between-meal coverage. It can simplify daily routines by combining basal and prandial needs in two injections for many adults. Pen dosing may feel more discreet and portable than vial-and-syringe options. Fixed ratios can make day-to-day routines more predictable when meal patterns are steady.

Side Effects and Safety

• Low blood sugar, with symptoms such as shakiness, sweating, or hunger
• Injection-site reactions including redness or irritation
• Lipodystrophy or skin thickening at injection areas
• Peripheral edema
• Rash or pruritus
• Weight gain

Serious risks can include severe hypoglycemia, hypokalemia, and allergic reactions. Fluid retention may worsen when used with thiazolidinediones. Beta blockers and certain other agents may mask or alter symptoms of hypoglycemia. Seek urgent care for severe low blood sugar, significant hypersensitivity, or signs of ketoacidosis.

Drug Interactions and Cautions

Drugs that lower glucose (for example, metformin or GLP-1 receptor agonists) may increase insulin effect. Agents that raise glucose (such as corticosteroids or some decongestants) may increase requirements. Alcohol can enhance or reduce insulin effect. ACE inhibitors and certain others can potentiate hypoglycemia, while thiazolidinediones can cause fluid retention and may precipitate heart failure. Always review the label and consult your prescriber before changes to therapy.

What to Expect Over Time

With consistent use, meal and between-meal patterns may become more stable. Your prescriber may adjust doses over time based on meter or CGM trends, meals, and activity. Keep logs of readings, injections, and carbohydrate intake to support decision-making. Report frequent lows or persistent highs to your clinician so the plan can be reassessed against the official labeling.

Compare With Alternatives

Other premixed or pen-based options may be considered if a different ratio or device fits better. Examples include Novomix® Penfill Cartridges 30 for an insulin aspart premix and Humalog Mix® Kwikpens if a disposable prefilled pen is preferred. Your prescriber can help determine which format and ratio align with your meals and A1C goals.

Pricing and Access

Select the ratio and pack size to view current pricing. Humalog Mix 75/25 cartridges price varies by pack and market. After reviewing options, you can add the item to your cart and upload or have us obtain your prescription. Explore multi-pack value in Bulk Savings and check Promotions for neutral, time-limited offers. Self-pay users can compare the cash price to typical local rates for context.

Availability and Substitutions

Supply can vary by ratio and pack size. If a specific presentation is not available, your prescriber may recommend a comparable premix or a basal–bolus plan. Order Humalog Mix 50/50 cartridges when your clinician confirms the ratio suits your needs. Do not switch ratios or regimens without professional guidance and label review.

Patient Suitability and Cost-Saving Tips

This option may suit adults who eat regular meals and prefer fewer daily injections. It is not for DKA management or pump use. People with recurrent severe hypoglycemia or highly variable schedules may need a different plan. To reduce costs, consider multi-month fills if your prescription allows, align refills with other medicines, and set refill reminders. Compare Insulin lispro mix cartridges price across pack sizes and plan refills ahead of travel.

Questions to Ask Your Clinician

• Which ratio best matches my meals and current glucose patterns?
• How should I time injections relative to breakfast and dinner?
• What signs of hypoglycemia should I watch for and treat?
• How do dose adjustments work if my meals or activity change?
• Which injection sites should I rotate through, and how often?
• What should I do if my readings run high for several days?
• Are there medicines I take that could affect insulin needs?

Authoritative Sources

FDA DailyMedHealth Canada DPDEli Lilly (Manufacturer)

Ready to proceed? Add to cart, upload your prescription, and check out for US delivery from Canada with prompt, cold-chain shipping. Information here is educational and not a substitute for the official label or your prescriber’s advice.