Interceptor Plus® Chewable Tablets for Dogs

Interceptor Plus is a monthly parasite preventive for dogs. It helps prevent heartworm disease and treats several intestinal worms. You can review Canadian pricing with US delivery from Canada, which may help if paying without insurance.

What Interceptor Plus Is and How It Works

Interceptor Plus® combines milbemycin oxime and praziquantel. This combination prevents heartworm disease and treats and controls roundworms, hookworms, and tapeworms. Many dogs accept the flavored tablet by mouth. Interceptor Plus® chewables provide broad internal parasite coverage when given on a regular schedule.

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Milbemycin oxime targets developing heartworm larvae transmitted by mosquitoes. It also acts against common roundworm and hookworm species. Praziquantel damages tapeworm structures so they can be cleared by the body. Given monthly, the treatment supports ongoing protection during parasite seasons and year-round, as advised by your veterinarian.

Who It’s For

This medicine is for dogs and puppies that require heartworm prevention and intestinal worm control. Puppies can start as early as 6 weeks of age when they meet minimum weight guidance from the label. Interceptor Plus for puppies is selected by weight class to ensure an appropriate dose. Dogs should test negative for existing heartworm infection before starting any preventive. Avoid use if your dog has had prior reactions to milbemycin oxime or praziquantel. Discuss use in breeding, pregnant, or lactating dogs, as the label may have specific cautions.

Dosage and Usage

The product is given by mouth once every month on the same date. Give a single chewable from the correct weight band. Interceptor Plus dosage for dogs follows the labeled schedule; your veterinarian’s directions take priority. Offer the chew by hand or place it in a small amount of food to ensure it is swallowed. If your region has year-round mosquito exposure, your prescriber may recommend continuous monthly administration. Do not exceed the recommended amount for your dog’s weight.

Before starting, have your dog tested for heartworm infection. Continue regular testing as advised by your veterinary professional. If your dog spits out part of a dose, contact your clinic for guidance on whether a replacement dose is needed.

Strengths and Forms

This treatment is supplied as flavored chewable tablets in multiple weight ranges. Common presentations include 2–8 lbs, 8.1–25 lbs, 25.1–50 lbs, and 50.1–100 lbs. Packages are color-coded for quick identification, such as blue, green, or yellow options, depending on the size. Availability may vary. Select the chewable that matches your dog’s current weight; growth in puppies may require a higher weight band at the next refill. For mid-range dogs, confirm the correct box strength before you order.

Owners sometimes search for specific sizes by range. For example, Interceptor Plus 25-50 lbs refers to a mid-weight option; similar bands exist for 2–8 lbs, 8.1–25 lbs, and 50–100 lbs. If your dog is at the upper or lower edge of a range, ask your veterinarian which pack is appropriate.

Missed Dose and Timing

If a monthly dose is missed, give it when remembered and resume the regular schedule. Avoid giving two full doses on the same day unless your prescriber instructs you to do so. If more than one month has lapsed, consult your veterinarian about heartworm testing before restarting. Try using reminders, calendar alerts, or pairing dosing with a monthly event to support adherence.

Storage and Travel Basics

Store chewables in the original packaging at room temperature, away from moisture and direct light. Keep out of reach of children and pets. When traveling, carry enough tablets for the entire trip and a copy of the prescription or order receipt. Pack doses in your hand luggage to avoid temperature extremes and loss. Do not use tablets that are damaged, unusually soft, or past the labeled expiration date.

Benefits

• Broad parasite control: prevents heartworm and treats key intestinal worms
• Once-monthly dosing: simple schedule supports adherence
• Palatable chew: many dogs take it as a treat
• Multiple weight bands: coverage for small and large dogs
• Convenient refills: align with routine wellness visits

For tapeworm information in pets, see our guide on Tapeworm Treatment.

Side Effects and Safety

• Digestive upset: vomiting, diarrhea, or soft stool
• Reduced appetite: mild and transient in some dogs
• Lethargy: low energy or sleepiness after dosing
• Drooling: usually brief and self-limited

Serious effects are uncommon but can include neurologic signs such as tremors, ataxia, or seizures, especially in dogs with a history of neurologic disease or certain genetic variants (MDR1). Dogs with existing heartworm infection may experience reactions if microfilariae are present. Seek veterinary care if you notice persistent vomiting, severe weakness, collapse, or any seizure activity.

Drug Interactions and Cautions

Tell your veterinarian about all medicines and supplements your dog receives. Use caution with other macrocyclic lactones or with high-dose ivermectin treatments. Some flea products containing spinosad may increase the risk of side effects in sensitive dogs. Herding breeds with MDR1 variants may require added caution. If your dog has a history of seizures or severe allergic reactions, discuss risks and benefits before starting therapy. For broader antibiotic context in pets, review Antibiotic Uses.

What to Expect Over Time

With consistent monthly dosing, protection is maintained across seasons. Your veterinarian may recommend continuing year-round in many regions. Routine heartworm testing helps monitor for unexpected exposure or missed doses. Keep a dosing log and confirm the chew is swallowed each month. If your dog gains weight or reaches a new size band, update the pack strength at the next refill to stay within the labeled range.

Compare With Alternatives

For heartworm prevention with a different active ingredient profile, consider Heartgard. For broad deworming options focused on intestinal parasites, some prescribers may choose Milbemax. Your veterinarian can help select the right spectrum based on your dog’s risk factors and local parasite pressures. Compare labels before switching.

Pricing and Access

See current pricing on each pack size and check expected cash-pay value for your household. We list Canadian pricing with US shipping from Canada for eligible addresses. If your out-of-pocket costs matter, view multi-pack options to reduce per-dose expense. For occasional coupons, visit our Promotions page. You can also browse related items in Pet Medications. Our encrypted checkout supports a secure transaction flow. For transparency, your clinic’s prescription directions must match the item you request.

If you compare budgets, Interceptor Plus without insurance may fit better when selecting a 6 or 12-month supply for a single pet. Ask your prescriber about a written prescription covering refills to streamline future orders.

Availability and Substitutions

Stock levels can vary by weight band. If a size is unavailable, your prescriber may recommend an alternative in the same class or a temporary substitute with comparable coverage. Do not change weight bands without veterinary guidance. We cannot provide restock dates, but labeled alternatives may be appropriate if timing is a concern.

Patient Suitability and Cost-Saving Tips

This medicine may suit dogs needing combined heartworm prevention and broad intestinal worm control. It may not suit dogs with prior neurological reactions, certain genetic sensitivities, or those under the minimum age or weight. If your pet has chronic conditions, coordinate with your veterinarian before starting any new preventive.

• Refill planning: align orders to keep the monthly schedule
• Multi-month fills: fewer shipments and lower per-dose pricing
• Weight checks: update size bands as puppies grow
• Reminders: calendar or app alerts improve adherence
• Clinic coordination: request refills in advance of the next due date

For general wellness context in older pets, you may find Arthritis In Dogs helpful when planning year-round preventives.

Questions to Ask Your Clinician

• Is year-round prevention recommended for my region and lifestyle?
• Which weight band best fits my dog’s current size?
• How should I handle a missed or partial dose?
• Are there concerns with my dog’s other medicines or supplements?
• When should I schedule heartworm testing and fecal checks?
• Should I consider a 12-month supply to reduce per-dose costs?

Authoritative Sources

FDA Animal & Veterinary

Elanco (Manufacturer)

Health Canada Drug Product Database

Ready to proceed? Start your order with prompt US shipping from Canada and temperature-controlled handling when required. This information is educational and does not replace your veterinarian’s advice.