Palladia® Tablets for Canine Mast Cell Tumors

Palladia is a veterinary cancer medicine for dogs. It is used to treat certain skin mast cell tumors. You can order it with US shipping from Canada, and many customers pay cash without insurance. This page explains what it is, who it suits, and how to use it safely.

What Palladia Is and How It Works

Palladia® contains toceranib, a targeted anticancer agent for dogs. It belongs to a class called tyrosine kinase inhibitors. This medicine can slow or stop tumor cell growth and reduce tumor blood supply.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

The active ingredient is toceranib phosphate. It inhibits several signaling pathways, including KIT, PDGFR, and VEGFR, which are often active in mast cell tumors. By blocking these pathways, the treatment may shrink tumors or stabilize disease. Effects can vary by tumor biology and patient health.

Who It’s For

This treatment is approved for recurrent cutaneous mast cell tumors in dogs. It may be used when surgery is not possible or after prior local therapy. A veterinarian decides if this is appropriate based on tumor grade, location, and spread.

Palladia for dogs is not for human use. It should not be used in breeding, pregnant, or lactating dogs. Dogs with significant gastrointestinal disease, severe kidney or liver disease, uncontrolled infection, or uncontrolled hypertension may not be candidates. Your veterinarian will review medical history and recent lab results before starting.

Dosage and Usage

Veterinarians commonly start dosing every other day. The label-recommended starting dose is weight-based. Your clinician will calculate the exact dose and schedule for your dog.

Give the tablets whole. Do not split, crush, or chew. Administer with or without food as directed by your veterinarian, and give with water. Wash hands after handling; caregivers should use gloves if tablets are broken or moistened.

Monitoring is important. Vets often check blood counts, kidney and liver values, blood pressure, and urine protein at regular intervals. Report vomiting, diarrhea, black stool, loss of appetite, lethargy, or signs of abdominal pain promptly.

Ask your veterinarian about anti-nausea or gastrointestinal protectants when appropriate. The dose may be paused or adjusted if adverse effects occur. Never change the regimen without veterinary guidance.

For clarity, your provider may discuss the palladia dosage for dogs using your pet’s weight and response. Always follow the prescribed plan and clinic instructions.

Strengths and Forms

This medicine is available as oral tablets for dogs. Strengths are commonly published in several fixed tablet sizes to allow weight-based dosing. Product availability may vary by pharmacy and stock.

These are film-coated tablets intended for whole dosing. Use safe handling practices and keep the original container to maintain labeling and safety information.

Missed Dose and Timing

If you miss a dose, give it when you remember unless it is close to the next scheduled dose. If it is near the next dose, skip the missed dose and resume the regular schedule. Do not double up to make up for a missed dose.

Try to dose at the same time of day on each dosing day. Keeping a log or calendar can help maintain consistent administration.

Storage and Travel Basics

Store tablets at room temperature and protect from moisture. Keep the container tightly closed and out of reach of children and other animals. Do not store in humid areas like bathrooms.

For travel, keep tablets in the original labeled container. Pack enough supply for the planned time away, along with your vet’s contact details and a copy of the prescription. A pill organizer is acceptable if you can maintain dose labeling, but the original container is preferred during transport.

When flying, keep medicines in carry-on baggage and bring documentation if asked. Follow local regulations for pet medications at your destination. Dispose of unused or expired tablets according to veterinary or pharmacy guidance.

Benefits

This targeted therapy can be given at home, which many caregivers find practical compared with clinic-only infusions. It acts on tumor signaling pathways, not just cell division, which may help control disease in certain cases.

Some dogs receive this oral option alone or in combination with other veterinary oncology care. Adjunct supportive care for the gastrointestinal tract is often used to improve tolerability. Because it is a tablet, logistics can be simpler than clinic-based palladia chemotherapy protocols that require IV access.

Side Effects and Safety

• Gastrointestinal upset: vomiting, diarrhea, decreased appetite
• Lethargy or weakness: reduced activity or tiredness
• Weight loss: gradual decline with poor appetite
• Lameness or pain: musculoskeletal discomfort
• Stool changes: dark, tarry, or bloody stool
• Skin changes: redness, ulceration, or delayed wound healing

Serious risks can include gastrointestinal ulceration or perforation, significant bleeding, severe dehydration, pancreatitis, low white blood cell counts, or liver and kidney effects. High blood pressure and protein in the urine can occur and may require treatment or dose adjustment. Call your veterinarian immediately for black stool, repeated vomiting, marked abdominal pain, collapse, or any rapidly worsening symptom.

Hypoglycemia is not typical with this class, but reduced intake from nausea may affect diabetic dogs. If your dog has concurrent conditions, monitoring plans may need adjustment.

Drug Interactions and Cautions

Use caution with nonsteroidal anti-inflammatory drugs, corticosteroids, or other medicines that can irritate the stomach or intestines. Combining with other myelosuppressive therapies may increase blood cell risks. Tell your veterinarian about all drugs and supplements, including heartworm preventives, antibiotics, antihypertensives, and herbal products.

People handling tablets should wash hands after contact. Avoid contact if pregnant or trying to conceive. Use gloves if a tablet is broken or if contact with body fluids is likely during cleanup after dosing.

What to Expect Over Time

Some dogs show tumor stabilization or reduction in size, while others have slower or limited responses. Side effects, if they occur, often appear early in treatment and may improve with dose holds, supportive care, or dose adjustments decided by the veterinarian.

Regular rechecks help assess your dog’s condition and quality of life. Keep a simple journal of appetite, activity, stool quality, vomiting episodes, and any visible tumor changes. Share this information at follow-up visits to support care decisions.

Compare With Alternatives

Veterinarians may consider other protocols based on tumor grade, location, and prior treatments. Injectable vinca alkaloids like Vincristine are used in multi-agent regimens for canine mast cell disease. Oral alkylating agents such as Leukeran (chlorambucil) may be options for some dogs under close monitoring.

Your oncologist will select therapy according to the dog’s overall status and goals of care. Combining targeted therapy with surgery, radiation, or cytotoxic agents may be discussed when appropriate.

Pricing and Access

You can buy palladia online through CanadianInsulin after we receive a valid prescription from your veterinarian. Transparent Canadian pricing is shown before checkout, and you can compare options for your budget. For coupons and seasonal offers, see our Promotions page.

Orders are processed with encrypted checkout, and the service Ships from Canada to US addresses where permitted. For more oncology products, explore our Cancer category and browse broader Pet Medications listings.

Availability and Substitutions

Supply can vary. If this medication is out of stock, your veterinarian may recommend a therapeutically appropriate alternative or an interim plan. Do not substitute with other products unless your prescriber confirms suitability.

Patient Suitability and Cost-Saving Tips

Good candidates can take oral tablets reliably and attend regular monitoring visits. Dogs with severe gastrointestinal disease or uncontrolled comorbidities may need a different approach.

For costs, ask about multi-month fills when stable on a dose. Set refill reminders to avoid gaps in therapy. Review monitoring schedules with your vet to plan lab visits efficiently. If you are managing a mast cell diagnosis, our Canine Mast Cell Tumor page has additional context you can discuss with your care team.

Pet oncology is evolving. For broader background on cancer research in dogs, you can read our article on comparative research topics like Osteosarcoma Metformin and discuss relevance with your veterinarian.

Questions to Ask Your Clinician

• Goals of care: control, shrinkage, or comfort
• Monitoring plan: lab tests and visit frequency
• GI protection: plans for nausea or ulcers
• Drug timing: with food or without
• Warning signs: when to call urgently
• Concurrent meds: safe pain and allergy options

Authoritative Sources

For official prescribing and safety information, review the manufacturer materials and regulatory monographs below, and ask your veterinarian for guidance:

• Zoetis Palladia product information is available from the manufacturer’s site; consult current professional materials for details. Zoetis Palladia Professional Information
• The FDA Center for Veterinary Medicine provides approval summaries and labeling updates for veterinary drugs. FDA CVM FOI Summary for Toceranib
• Health Canada Drug Product Database lists veterinary product records when applicable. Health Canada Drug Product Database

Ready to proceed? You can place your order with prompt shipping and temperature-controlled handling when required.

Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.