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Effient® Tablets for Acute Coronary Syndrome
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Prasugrel is an oral antiplatelet for adults after certain heart procedures. Many patients continue on prasugrel 10 mg once daily with aspirin after a loading dose. This page explains dosing, key risks, and how to order with US shipping from Canada, including options if you pay without insurance.
What Effient Is and How It Works
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Prasugrel belongs to the P2Y12 inhibitor class. It is a thienopyridine prodrug that is converted to an active metabolite. The active form irreversibly blocks ADP‑mediated platelet activation and aggregation. This mechanism helps reduce stent thrombosis and other clot‑related events after percutaneous coronary intervention.
Effient® is the reference brand for this medicine. Generics contain the same active ingredient and are evaluated for bioequivalence. Your cardiology team typically pairs this therapy with daily aspirin to enhance protection.
Who It’s For
This treatment is indicated to reduce thrombotic cardiovascular events in adults with acute coronary syndrome managed with PCI. For many appropriate patients, a prasugrel 10 mg tablet is taken each day with aspirin. Explore related options in our Heart Disease category.
People with a history of stroke or TIA should not use it. Active pathological bleeding is a contraindication. Use may not be recommended in adults 75 years and older except in high‑risk situations. Those under 60 kg may need a lower maintenance dose as described in the label. Discuss individual risks with your prescriber.
Dosage and Usage
Per the label, patients often receive a 60 mg loading dose as directed by their cardiology team. The usual maintenance dose is Prasugrel HCl 10 mg once daily with aspirin. Patients weighing under 60 kg may use 5 mg daily. Use in those 75 years or older is typically avoided unless the potential benefit outweighs risk. Take tablets at the same time each day, with or without food.
Swallow tablets whole with water; do not split or crush unless your prescriber advises. Therapy is used with aspirin and started as soon as feasible after PCI. Keep daily timing consistent to maintain platelet inhibition. Refer to the official label for full directions. For more background, see Prasugrel 10 Mg.
Strengths and Forms
Prasugrel is supplied as film‑coated tablets. Common strengths are 5 mg and 10 mg. The Effient 10 mg tablet served as the reference listed drug for many generics. Packaging and imprint may vary by manufacturer and market availability.
Missed Dose and Timing
If you miss a dose, take it when you remember on the same day. If the next dose is near, skip the missed dose and resume your schedule. Do not take two doses at once. If a loading dose is vomited shortly after intake, contact your prescriber for guidance. Follow the official label for any timing changes around procedures.
Storage and Travel Basics
Store tablets at room temperature in a dry place, away from moisture and heat. Keep in the original, child‑resistant container with the label intact. Do not use if the seal is damaged or tablets are discolored. For travel, pack doses in carry‑on luggage with a copy of your prescription. Keep medicines in original containers for security screening. Plan for time zone changes so your daily dose stays consistent, and carry extra doses in case of delays.
Benefits
This therapy helps lower the risk of heart attack, stroke, and stent thrombosis after PCI in ACS. Once‑daily dosing can simplify routines. The class provides potent, consistent platelet inhibition when taken as directed with aspirin. Generic versions offer clinically comparable effectiveness to the reference product.
Side Effects and Safety
- Bruising or easy bleeding
- Nosebleeds or gum bleeding
- Headache or dizziness
- Stomach discomfort or diarrhea
- Rash or itching
Serious risks include major bleeding, which can be life‑threatening. Rare events such as thrombotic thrombocytopenic purpura have been reported. Do not use this medicine if you have a history of stroke or TIA, or active bleeding. Tell your clinician about planned surgery or dental work; the label advises stopping therapy at least 7 days before elective procedures. Seek immediate care for signs of severe bleeding.
Drug Interactions and Cautions
Bleeding risk increases when combined with anticoagulants such as warfarin or direct oral anticoagulants, other antiplatelets, or chronic NSAIDs. Select antidepressants (SSRIs and SNRIs) may also raise bleeding risk. Strong CYP inhibitors or inducers have limited impact, but caution is appropriate with any interacting therapy. Review all medicines and supplements with your prescriber. For context, see Warfarin Anticoagulant and Ticagrelor 90 Mg.
What to Expect Over Time
After a loading dose, platelet inhibition begins quickly. Ongoing daily doses maintain effect, so adherence is important. You may not feel a difference in day‑to‑day symptoms, because benefits relate to reducing clot‑driven events. Bleeding and bruising can occur at any time. Duration of therapy is individualized by your cardiology team based on stent type and risk profile. Regular follow‑up helps confirm that benefits continue to outweigh risks.
Compare With Alternatives
Several P2Y12 inhibitors are used after PCI. Clopidogrel is widely used and may be chosen for patients with a lower bleeding risk or who need a different interaction profile. Ticagrelor is another option with reversible binding and twice‑daily dosing. Selection depends on your clinical history, stent type, and the prescriber’s assessment.
Pricing and Access
Canadian pricing with licensed pharmacy dispensing can help lower out‑of‑pocket costs compared with typical local cash rates. To compare options, review our Heart Health Medications. Check the current prasugrel 10 mg price before you add to cart. Orders Ships from Canada to US with tracking. If you are looking for savings, see Promotions. Our encrypted checkout protects your information. You can also review the price for the 10 mg tablet and Canadian pricing for the 10 mg strength when planning refills.
Availability and Substitutions
Supply can vary by manufacturer and market. If a specific brand is unavailable, a prescriber may recommend a clinically suitable alternative. The generic for Effient 10 mg is available from multiple companies in different regions, such as Teva, Mylan, Accord, or Zentiva. Product images and imprints may differ, but the active ingredient and labeled dose remain the same. In some markets, local brands such as Prasudoc 10 mg may appear; naming varies by region. When an item is out of stock, your prescriber can advise on an alternative in the same class.
Patient Suitability and Cost-Saving Tips
This therapy may suit adults with ACS treated with PCI who have no history of stroke or TIA and no active bleeding. It may not be appropriate for some older adults, very low body weight patients, or those at high bleeding risk. To manage the prasugrel 10 mg cash price, consider multi‑month fills where appropriate, set refill reminders, and combine delivery with other medicines to reduce per‑shipment fees. Align refills ahead of travel and planned procedures, and follow the prescription directions.
Questions to Ask Your Clinician
- Is this antiplatelet right for my stent and risk profile?
- What maintenance dose should I use based on age and weight?
- How long should I stay on therapy after my procedure?
- What bleeding signs require urgent evaluation?
- Which medicines or supplements should I avoid or adjust?
- How should I manage dosing before surgery or dental work?
- What plan do we have for follow‑up and refills?
Authoritative Sources
FDA Prescribing Information: Effient (prasugrel)
Health Canada Drug Product Database
Ready to proceed? Place your order with express US delivery from Canada and temperature-controlled handling when required. This content is educational and does not replace medical advice; follow your prescriber’s directions and the official label.
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How does prasugrel compare with clopidogrel?
Both agents inhibit the P2Y12 receptor to prevent platelet activation. Prasugrel is an irreversible thienopyridine like clopidogrel but tends to produce more consistent platelet inhibition. That potency may increase bleeding risk in some patients. Clopidogrel is taken once daily, while prasugrel is also once daily after a loading dose. Choice depends on bleeding risk, prior stroke or TIA history, drug interactions, and your cardiology team’s preferences. Follow your prescriber’s plan and the product label for individualized decisions.
Can I crush or split these tablets?
Tablets are intended to be swallowed whole. Splitting or crushing can affect dose accuracy and may not be appropriate, especially at lower doses. If you have trouble swallowing, talk with your prescriber or pharmacist about alternatives. The official label provides guidance on administration. Do not alter tablets without professional advice, and keep dosing times consistent from day to day.
What bleeding precautions should I follow?
Use a soft toothbrush and electric razor to reduce minor bleeding. Avoid activities with high injury risk. Limit alcohol intake as advised. Report black stools, blood in urine, prolonged nosebleeds, coughing up blood, or unusual bruising. Inform all clinicians and dentists that you take a P2Y12 inhibitor. Do not start or stop NSAIDs, anticoagulants, or herbal supplements with bleeding risk unless your prescriber agrees.
How long is therapy usually continued after a stent?
Duration is individualized based on stent type, bleeding risk, and clinical course. Many patients use dual antiplatelet therapy for months to a year or longer, but your cardiology team sets the plan. Do not stop therapy without guidance, because stopping early can raise the risk of stent thrombosis. If surgery or procedures are planned, your prescriber will outline timing for any changes.
What should I know about surgery or dental work?
Let your surgical and dental teams know you take a P2Y12 inhibitor. The label advises stopping prasugrel at least 7 days before elective procedures to reduce bleeding, but only do so under your prescriber’s direction. Your clinician will balance clotting risk and procedure needs. Resume therapy as instructed after the procedure, and confirm aspirin plans as well.
Does low body weight change the dose?
The product label notes that patients under 60 kg may require a lower maintenance dose due to bleeding risk. Older adults, especially those 75 years or above, may not be candidates unless benefits outweigh risks. Never adjust doses on your own. Your prescriber will select an initial loading dose and maintenance plan based on your weight, age, and clinical factors.
Is prasugrel safe during pregnancy or breastfeeding?
Human data are limited. Use during pregnancy or breastfeeding should be considered only if the expected benefit justifies potential risks. Your prescriber will weigh maternal cardiovascular risk, bleeding concerns, and available alternatives. If exposure occurs, report any unusual bleeding and follow up promptly. Consult the official label and your healthcare professional for individualized guidance.
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