ProHeart 6® Injection for Dogs

This veterinarian-administered heartworm preventive protects dogs for six months. It provides continuous coverage with a single shot. This page explains how it works, who it suits, and helps you review options with US delivery from Canada and typical costs without insurance.

What ProHeart 6 Is and How It Works

ProHeart 6® is a sustained-release moxidectin preventive for dogs. The ProHeart 6 injection provides six months of protection against heartworm disease by maintaining steady levels of active ingredient. After subcutaneous administration by a veterinarian, the microspheres slowly release moxidectin, which targets heartworm larvae transmitted by mosquitoes before they mature. At the time of administration, it may also address certain hookworm infections as described in the official label.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

Dogs should test negative for heartworm infection before receiving this treatment. Clinics typically confirm a recent antigen test and assess overall health history. This medicine is designed for clinic administration only; owners do not inject it at home.

Who It’s For

ProHeart 6 for dogs prevents heartworm disease for six months in eligible dogs at least six months of age. It suits households that prefer long-interval prevention instead of monthly dosing. It can be considered for dogs that miss oral doses or dislike chews. Dogs with current illness, unexplained weight loss, or a history of drug or vaccine reactions may need additional evaluation. Discuss pregnancy, breeding status, and breed sensitivities with a veterinarian before use.

Dosage and Usage

A veterinarian administers the 6 month heartworm injection for dogs during a clinic visit. The injection is placed subcutaneously as a single dose, with protection intended to last six months. Dogs should be tested for existing heartworm infection before each appointment. Clinics monitor for potential sensitivity following administration and provide post-visit guidance. Owners should not attempt to reconstitute or inject this product themselves.

Schedule repeat appointments at six-month intervals as directed on the label. If a prescriber recommends co-administered vaccinations or other preventives, the clinic will set an appropriate sequence. When uncertain about timing relative to other therapies, defer to the official label and veterinary guidance.

Strengths and Forms

The ProHeart 6 moxidectin injection is supplied as a clinic-use kit that is reconstituted before use. Packaging may include a vial of microspheres and a separate diluent for preparation. After reconstitution, the product becomes a sterile injectable suspension for subcutaneous administration. Concentration and presentation can vary by market and packaging; availability may differ by pharmacy and region.

Missed Dose and Timing

If a scheduled appointment for the six month heartworm shot is missed, contact the clinic to reschedule as soon as practical. The prescriber may confirm a new heartworm test depending on the timing and local recommendations. Do not attempt to administer any leftover materials at home or change timing without veterinary direction.

Storage and Travel Basics

This product is intended for clinic storage and handling under labeled conditions. Veterinary staff manage reconstitution, injection technique, and record keeping. Pet owners generally do not store the vials at home. When arranging clinic delivery, ensure the receiving clinic is available to accept and store the parcel appropriately, following temperature-controlled handling when required.

For travel planning, keep appointment dates and vaccination records together. If moving or changing clinics, request medical records and the most recent heartworm test result to avoid duplicate testing. Keep medicines and sharps away from children and pets. Dispose of packaging and clinic consumables according to local regulations.

Benefits

This treatment provides long-interval prevention in a single clinic visit. It helps support adherence by removing monthly dosing steps. The formulation avoids chewable flavors and palatability issues. Clinic administration includes ongoing assessment of weight and health status, which can inform broader care.

• Six months of continuous heartworm prevention
• Clinic-administered single injection
• Helps reduce missed monthly doses
• No chew or topical mess at home
• Suitable for many adult dogs after testing

Side Effects and Safety

• Transient lethargy or decreased activity
• Vomiting or diarrhea
• Reduced appetite
• Injection-site swelling, pain, or small lump
• Itching or hives

Serious but less common reactions can include anaphylaxis, collapse, seizures, or severe gastrointestinal signs. Immediate veterinary care is needed if any signs of shock or breathing difficulty occur. Dogs with a history of drug hypersensitivity, significant skin disease, or chronic weight loss may need additional evaluation before use. Screening for heartworm infection prior to administration is important to minimize complications.

Drug Interactions and Cautions

Moxidectin is a macrocyclic lactone. Use caution when combining with other drugs in this class, or with therapies known to affect P-glycoprotein transport. Breeds with MDR1 gene variants may be more sensitive to certain medicines. Report all current therapies, including preventives, antibiotics, and anti-inflammatories, before administration. Commonly prescribed agents such as Cephalexin For Dogs or Clavamox For Dogs are often compatible, but only a veterinarian can assess individual risks. Alcohol, human supplements, or off-label products should not be given without professional guidance.

What to Expect Over Time

After the heartworm 6 month shot, protection is maintained through the labeled interval when administered correctly. Clinic teams may schedule the next visit at checkout to encourage continuity. Annual testing remains standard, even when long-acting prevention is used. If any adverse signs appear after injection, contact a veterinarian promptly. Dogs may need separate flea and tick control, as this medicine does not address those parasites.

Compare With Alternatives

Monthly preventives remain appropriate for many dogs. Chewable ivermectin products and topical selamectin are well-established options. Some owners prefer an oral chew such as Heartgard®, while others use a topical like Revolution® For Dog. Each option differs in route, spectrum, and dosing frequency. Veterinary history, lifestyle, and adherence drive the choice. Discuss testing requirements and parasite risks in your region before switching therapies.

Pricing and Access

Canadian-based pharmacies dispense to US clinics with prescription verification. Many customers review ProHeart 6 price without insurance to understand expected out-of-pocket spending. Compare Canadian pricing with local clinic quotes to see potential savings. This item Ships from Canada to US, subject to prescriber validation and clinic acceptance. See current pricing, start an order, and select the receiving clinic during checkout. For seasonal offers, visit Promotions.

Availability and Substitutions

Supply can vary by clinic and pharmacy distribution. If a requested package is unavailable, a prescriber may recommend a suitable alternative or a different prevention schedule. For intestinal tapeworms, a targeted product may be required; see our overview of options in Effective Tapeworm Treatment. For broader veterinary selections, browse Pet Medications. Restock dates are not guaranteed.

Patient Suitability and Cost-Saving Tips

Good candidates include adult dogs who are heartworm-negative, can attend regular clinic visits, and have no history of severe drug reactions. Dogs with significant comorbidities, advanced age, or herding breeds with known sensitivity may require tailored planning. To manage costs, coordinate wellness visits with prevention appointments, consider multi-pet scheduling, and ask about clinic reminder systems. A predictable six-month interval can reduce lapses that sometimes occur with monthly dosing. For mobility or chronic pain considerations, see our guide on Arthritis In Dogs And Cats.

Questions to Ask Your Clinician

• Is the dog an appropriate candidate based on age and testing?
• What monitoring should the clinic perform after the injection?
• How does this prevention fit with flea and tick control?
• Are any current medicines or supplements a concern?
• What signs after the visit should prompt a call?
• When should the next heartworm test be scheduled?
• Which clinic records should be kept for travel or boarding?

Authoritative Sources

Zoetis Product Page | FDA NADA 141-189 | Health Canada Drug Product Database

Place your order with CanadianInsulin for US shipping from Canada with prompt, express, cold-chain shipping. This information is for educational purposes and does not replace veterinary advice; always follow the official label and your prescriber’s instructions.