ProHeart 6 Injection for Dogs

ProHeart 6 is a veterinary prescription medicine given as a long-acting injection to help prevent heartworm disease in dogs and treat certain hookworm infections. This page summarizes practical basics, including how the drug class works, what the clinic visit usually involves, and key safety and storage points to review with a veterinary team. CanadianInsulin is a prescription referral platform that helps route valid prescriptions for US shipping from Canada, with cash-pay access for those without insurance.

What ProHeart 6 Is and How It Works

This product contains moxidectin, a macrocyclic lactone (antiparasitic drug class) formulated for extended release after a subcutaneous injection. After administration, the medicine circulates at levels intended to prevent developing heartworm larvae from maturing into adult worms. It also has activity against certain intestinal hookworms, which are common parasites that can cause diarrhea, weight loss, and anemia in dogs.

CanadianInsulin coordinates prescription referral; licensed Canadian pharmacies dispense approved veterinary prescriptions. This medication is not an adulticide, meaning it does not remove existing adult heartworms. Veterinary screening is commonly part of prevention plans, especially when a dog’s prior prevention history is unknown. For background on risk and disease basics, browse the Canine Heartworm Disease hub and the Canine Hookworm Infection hub.

Who It’s For

This injectable prevention option is used in dogs when a clinic and owner prefer a longer interval between doses. It may be considered for dogs that have trouble taking monthly tablets, dogs in high-risk mosquito areas, or households where adherence is hard to maintain. Many veterinary practices also pair parasite prevention with routine wellness care, including weight checks and review of other medicines.

Eligibility depends on the veterinary label and clinical judgment. ProHeart 6 is generally used in dogs old enough for the approved age range and healthy enough for an injection visit. It is not appropriate for every dog, including those with known hypersensitivity to ingredients or dogs that are ill or debilitated. For a broader view of prescription options that clinics may use alongside prevention, the Pet Medications category can be used to browse by type.

Dosage and Usage

This medicine is administered by a veterinary professional as a single injection on a set schedule, commonly every six months. Dose selection is weight-based and follows the official prescribing information, so an accurate current weight matters. ProHeart 6 should not be self-administered at home, and the clinic may require testing before starting or restarting, depending on a dog’s history and local practice standards.

When a scheduled visit is delayed, the veterinary team typically advises how to re-establish prevention and whether additional testing is needed. Keeping a written date of each injection and the dog’s weight at the visit can help reduce missed intervals. If a dog has recent travel, prior gaps in prevention, or unclear records, clinics often document those factors before giving the injection.

What a Veterinary Appointment Often Covers

Many clinics follow a repeatable workflow for long-acting parasite prevention. Staff may confirm the dog’s current weight, review recent illnesses, and ask about reactions to prior injections. A heartworm screening test may be performed when indicated, and the team may observe the dog briefly after administration to watch for immediate hypersensitivity signs. If nausea or vomiting is a concern after any veterinary treatment, the clinic may discuss supportive care options; for general background on antiemetic (anti-nausea) medicines used in veterinary practice, see Cerenia Uses And Dosage.

Strengths and Forms

This product is supplied as a veterinary injectable formulation intended for in-clinic use. The dose is calculated and prepared by trained staff, which helps reduce handling errors and supports proper administration technique. Because it is an extended-release product, preparation and injection methods described in the official labeling are important to follow, including any steps related to mixing and administration timing.

Availability can vary by pharmacy supply and clinic ordering patterns. Some pet owners compare long-acting injectable prevention with monthly oral or topical preventives, while others focus on the clinic-administered schedule. A veterinary team can confirm the correct presentation for the dog’s weight and can advise how the injection fits into a broader parasite control plan.

Storage and Travel Basics

Storage is usually handled by the clinic because the product is administered on-site. Veterinary staff follow the package labeling for temperature range, light protection, and beyond-use handling after preparation. Pet owners typically do not need to transport or store the medication at home, which can simplify routine prevention compared with products kept in a household medicine cabinet.

Quick tip: Keep the injection date and clinic paperwork with the dog’s vaccination records.

For travel planning, the main practical issue is documenting the prevention window and scheduling the next visit before the interval ends. Dogs moving between regions may face different parasite exposures, including intestinal worms that can be picked up from soil or feces in shared environments. For additional context on parasite treatment approaches beyond heartworm prevention, see Droncit Tapeworm Treatment as a separate, condition-specific example.

Side Effects and Safety

As with many veterinary injections, side effects can occur and range from mild to serious. ProHeart 6 may be associated with temporary gastrointestinal signs (such as vomiting or diarrhea), reduced appetite, lethargy, or localized injection-site reactions like swelling or discomfort. Some dogs may also develop itchiness or hives, which can be signs of a hypersensitivity response.

Why it matters: Early recognition of allergic reactions supports faster veterinary care.

More serious reactions can include collapse, breathing difficulty, pale gums, weakness, or persistent vomiting. Clinics may recommend observing a dog for a period after the injection and monitoring at home later the same day. Report any concerning signs to a veterinarian promptly, especially if symptoms are sudden or progressive. Some requests require prescription confirmation with the prescribing clinic. For general education on how side effects are described for other pet prescriptions, compare how reactions are outlined in resources like Apoquel Uses And Side Effects and Deramaxx Safety Overview.

Drug Interactions and Cautions

Veterinary teams consider a dog’s full medication list before administering long-acting parasite preventives. Caution is often used when combining therapies that affect the nervous system, and clinics may review other parasiticides in the same drug class. Some dogs have an MDR1 gene variant that can increase sensitivity to certain drugs; a veterinarian can advise whether that history changes product selection or monitoring plans.

It is also important to share recent vaccinations, supplements, and any current antibiotics or anti-inflammatories with the clinic before an injection visit. Not all combinations are problematic, but complete information supports safer decision-making and more accurate adverse event assessment if symptoms occur afterward. For an example of how dosing and cautions are presented for a common veterinary antibiotic, see Cephalexin Uses And Dosage.

Compare With Alternatives

When comparing prevention strategies, clinics often look at dosing interval, administration route, and parasite coverage. ProHeart 6 is clinic-administered on a longer schedule, while many alternatives are monthly products given at home. Examples include oral preventives such as Heartgard Product Page and Interceptor Plus Product Page, as well as topical options used for broader parasite control in some dogs.

Longer-interval injections can reduce missed doses, but they still require scheduled clinic visits and follow-up records. Monthly preventives offer flexibility and can be stopped or changed more quickly if intolerance occurs, but they depend on consistent administration. A veterinary professional can weigh local parasite risk, prior prevention gaps, and the dog’s health status before selecting a prevention approach.

Pricing and Access

Costs for long-acting heartworm prevention commonly vary by dog weight and clinic-level services that may be required at the visit. In addition to the medication itself, a veterinary appointment may include an exam, screening tests, and administration fees. When reviewing ProHeart 6, clinics may also consider regional heartworm prevalence and whether additional parasite control is needed based on stool testing or exposure history.

For access through CanadianInsulin, a valid veterinary prescription is required, and some orders may involve confirming details with the prescriber. The service supports cash-pay access for clients who are without insurance. Depending on the product and destination, US delivery from Canada may be available for eligible prescriptions. If the goal is to understand site-wide offers rather than medication selection, the Site Promotions page lists current programs.

Authoritative Sources

For the most reliable details on indications, contraindications, and administration steps, refer to official prescribing information and established veterinary guidance. Clinics may also use regional heartworm prevention recommendations to decide when testing is needed and how prevention fits into year-round parasite control. These sources can support informed discussions with a veterinary professional and help clarify what the product is designed to do.

• Review clinical guidance from the American Heartworm Society Guidelines.
• Check U.S. regulatory references via FDA Animal Drugs@FDA.
• Read manufacturer materials from Zoetis ProHeart.

To submit a prescription request through the site, follow checkout steps and select prompt, express, cold-chain shipping when applicable.

This content is for informational purposes only and is not a substitute for professional medical advice.