Simparica® Chewable Tablet for Dogs

Simparica is a monthly prescription chew for dogs that kills fleas and ticks. It belongs to the isoxazoline class and helps control mite infestations that cause sarcoptic mange. This page explains dosing, sizes, safety, and how to order with US delivery from Canada without insurance.

What Simparica Is and How It Works

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Simparica® contains sarolaner, an ectoparasiticide. It targets flea and tick nervous systems, disrupting GABA and glutamate-gated chloride channels in parasites. In effect, it kills adult fleas and multiple tick species that transmit serious diseases. The chew starts working after administration and maintains activity for a full month between doses when used as directed.

Many pet owners look for simparica for dogs when they want month-long, broad-spectrum protection in a single chew. This treatment may also help manage sarcoptic mange by killing the mites involved. It can be given with or without food.

Who It’s For

This medicine is for dogs that need prevention and treatment of flea infestations and control of tick infestations. It is labeled for dogs six months of age and older and above the lowest weight band specified on the package insert. It is not for cats or other species.

Use caution in dogs with a history of seizures, ataxia, or other neurologic disorders. The isoxazoline class has been associated with neurologic adverse reactions in a small number of animals. The safety in breeding, pregnant, or lactating dogs has not been established; your veterinarian may advise alternatives in those situations. For flea-related skin disease, review our guides on Canine Flea Infestation, Canine Tick Infestation, and Canine Mange for condition-specific context.

Dosage and Usage

Administer one chew once each month, on or about the same date. Give the full dose that matches your dog’s current body weight. You may offer the chew by hand, with food, or place it in a small meal; observe to ensure the tablet is fully consumed. If your dog hides or spits out chews, present it as a treat after light play, or place it in a small portion of a staple food.

Only one simparica chewable tablet for dogs should be given per month unless your veterinarian instructs otherwise. Continue monthly dosing throughout the flea and tick season for your region. If your dog’s weight changes and crosses into a different band, speak with your veterinarian about moving to the correct tablet strength at the next monthly dose.

Strengths and Forms

This product is supplied as flavored chewable tablets containing sarolaner in strengths corresponding to dog weight bands. Common presentations include packages for the following body weight ranges: 2.8–5.5 lb (5 mg), 5.6–11.0 lb (10 mg), 11.1–22.0 lb (20 mg), 22.1–44.0 lb (40 mg), 44.1–88.0 lb (80 mg), and 88.1–132.0 lb (120 mg). Pack sizes vary by market and may include three- or six-dose cartons. Availability can vary.

Owners often select by labeled weight band, such as simparica 5.6 11 lbs, to match their dog’s current weight. If your dog is at the top or bottom of a range, verify the correct band with your veterinarian before ordering.

Missed Dose and Timing

If you miss a monthly dose, give it when remembered and then resume the monthly schedule from that date. Do not give two doses at once. Setting reminders on a calendar or phone can help maintain a consistent schedule. If vomiting or refusal occurs, contact your veterinarian for guidance on re-dosing.

Storage and Travel Basics

Store the chews in the original blister until use. Keep at room temperature, away from moisture and direct sunlight. Secure all pet medicines out of reach of children and animals.

When traveling, carry the carton or a photo of the label, and your prescription details. Pack an extra dose if you will cross your scheduled date during travel. Avoid leaving the product in a hot car. For personal recordkeeping, note the dose date on your phone or a calendar after each administration.

Benefits

This treatment helps stop flea infestations by killing adult fleas before they can lay eggs. It also controls key tick species that can transmit pathogens. Dogs usually need only one chew per month, which simplifies routine care for many households.

Many owners prefer a single monthly chew that covers multiple parasites. For broad coverage, some search terms include simparica flea and tick. The flavored chew form may help with acceptance in dogs that resist topical spot-ons.

Side Effects and Safety

• Digestive changes: vomiting, diarrhea, decreased appetite
• Skin or coat: pruritus, hair changes, mild redness
• Behavioral: lethargy, restlessness
• Neurologic: tremors, incoordination, rare seizures

Serious adverse events are uncommon but can occur. The isoxazoline class has been associated with neurologic adverse reactions, particularly in dogs with a history of such issues. If your pet shows concerning signs, contact your veterinarian promptly. Discuss whether sarolaner for dogs is appropriate if your dog has known neurologic conditions or is on medications that may lower seizure threshold.

Drug Interactions and Cautions

Provide your veterinarian a full list of your dog’s medicines, supplements, and preventives. Caution is advised when combining multiple ectoparasiticides unless directed by your veterinarian. Vaccines, dewormers, and most routine preventives are commonly co-administered in practice; defer to your veterinarian for your dog’s specific plan.

For very young animals needing topical options, see Puppies and Kittens guidance and products. In multi-pet homes that include cats, fast-acting tablets like Capstar are sometimes used; see Cat and Dog for details. Explore broader categories such as Pet Medications to review related items.

What to Expect Over Time

After dosing, you may see a reduction in itching and visible fleas as adults are killed. Ticks that are already attached may be affected over time and can fall off or be removed as directed by your veterinarian. Monthly use helps keep new infestations from becoming established in the home environment.

For dogs with flea allergy dermatitis, consistent monthly prevention is important. Keep up routine cleaning of bedding and common resting areas to support parasite control. If your area has heavy tick pressure, discuss additional environmental strategies with your veterinarian.

Compare With Alternatives

Topical selamectin offers flea control with a different route of administration. Consider Revolution for Dog if a spot-on is preferred for your pet and lifestyle. For rapid knockdown of adult fleas, a single-dose oral nitenpyram option may be used as advised by your veterinarian; see Capstar for Dog.

Pricing and Access

Compare simparica price against local options to understand potential savings. Canadian pharmacy pricing can be attractive, and we provide US shipping from Canada for prescription orders. You can review available pack sizes and place an order after we verify your prescription. Checkout uses encrypted processes for your security.

If you are seeking coupon availability, see current, rotating offers on our Promotions page. Your total may still be favorable compared with many retail sources, even without insurance.

Availability and Substitutions

Supply can vary by strength and pack size. If an item is unavailable, your prescriber may recommend another approved flea and tick product with similar coverage. We cannot promise specific restock dates.

Patient Suitability and Cost-Saving Tips

This treatment suits many adult dogs who need monthly protection and accept oral chews. Dogs with neurologic conditions or those that are breeding, pregnant, or lactating may need alternatives per veterinary guidance. Always match the weight band on the carton to your dog’s current weight.

To save time and reduce lapses, consider multi-month refills when appropriate. Set calendar reminders on your phone on the dose date. Keep one spare dose on hand for travel. If your veterinarian adjusts simparica doses due to weight changes, update future refills to the new band.

Questions to Ask Your Clinician

• Appropriate weight band: which tablet size matches current weight
• Coverage needs: flea allergy, local tick species, mange risk
• Co-therapy: heartworm preventives or dewormers alongside this medicine
• Adverse effects: what signs warrant a call or visit
• Home environment: cleaning steps to support control
• Season length: how many monthly doses to plan

Authoritative Sources

For full prescribing details and label content, review the manufacturer’s overview: Zoetis Simparica Overview. For official labeling information, see FDA references for veterinary ectoparasiticides: FDA Simparica Labeling. Canadian product information can be found via Health Canada’s database: Health Canada Drug Product Database.

Ready to order? Add the correct weight band to your cart and check out with prompt, express, temperature-controlled handling when required. Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice.