Simparica® Chewable Tablets for Dogs

Simparica® is a prescription chewable for dogs that kills fleas and ticks. This page explains strengths, dosing, and safety in clear terms. It is ordered from Canada and ships to the US, with transparent Canadian pricing even if paying without insurance.

What Simparica® Is and How It Works

Simparica is sarolaner, an isoxazoline flea and tick preventive for dogs. It targets the nervous system of fleas and ticks, leading to rapid parasite death. Monthly dosing helps break flea life cycles and provides ongoing tick protection. The product is supplied from Canada with US delivery from Canada.

CanadianInsulin is a prescription referral service. We verify your prescription with your clinic, and licensed Canadian pharmacies dispense your order.

Simparica controls adult fleas and several tick species that commonly affect dogs. Label uses include the treatment and control of fleas and ticks, and the treatment and control of sarcoptic mange. It is a convenient chewable tablet that most dogs accept.

Who Simparica® Is For

Simparica is for dogs only. It is approved for dogs 6 months of age and older that weigh at least 2.8 lb (1.25 kg). It should not be used in cats. Do not use in puppies under 6 months or dogs below 2.8 lb.

Use caution in dogs with a history of seizures or neurologic disorders. The isoxazoline class has been associated with tremors, ataxia, and seizures in rare cases. The safety of Simparica in breeding, pregnant, or lactating dogs has not been established.

Dosage and Usage

Administer one chewable tablet by mouth once monthly. Choose the chew that matches the dog’s weight range. Give with or without food. Maintain a regular monthly schedule for continuous protection.

For sarcoptic mange, the labeled approach is monthly dosing for three treatments. Follow the weight-based chart and veterinarian guidance. Do not split tablets or give more than one tablet per month unless a veterinarian directs otherwise.

Strengths and Forms

Simparica chewable tablets are available in multiple strengths matched to body weight. Packaging sizes may include 3, 6, or 12 tablets per carton. Availability can vary.

• 5 mg for 2.8–5.5 lb dogs
• 10 mg for 5.6–11 lbs dogs (Simparica 5.6–11 lbs)
• 20 mg for 11–22 lbs dogs (Simparica 11–22)
• 40 mg for 22–44 lbs dogs (Simparica 22–44)
• 80 mg for 44–88 lbs dogs (Simparica 44–88)
• 120 mg for 88–132 lbs dogs (Simparica 88–132)

Each tablet delivers a once-monthly dose of sarolaner. Dogs over 132 lb may need a combination of tablets, as directed by a veterinarian.

Missed Dose and Timing

If a monthly dose is missed, administer a tablet when remembered and resume a monthly schedule from that date. Avoid double dosing. Keep a reminder on a phone or calendar to support steady protection.

Storage and Travel Basics

Store Simparica in the original blister at room temperature, away from moisture and light. Keep out of reach of children and other pets. Do not use tablets that are damaged or past the labeled expiration.

For travel, pack tablets in the original packaging and protect from heat. Bringing doses along helps maintain the monthly schedule. For US travel, no refrigeration is required.

Benefits

Simparica provides broad protection against fleas and multiple tick species with a single monthly chew. It helps stop flea infestations and reduces the risk of tick-borne disease transmission. The chewable form is simple to give, with or without food. Month-to-month dosing supports a consistent routine.

Side Effects and Safety

• Vomiting
• Diarrhea or soft stool
• Lethargy
• Decreased appetite
• Pruritus or skin irritation

Serious but uncommon events may include neurologic signs such as tremors, ataxia, or seizures. Stop treatment and contact a veterinarian if concerning symptoms appear. Dogs with a seizure history may be at higher risk. For itch flares unrelated to fleas, veterinarians may consider therapies such as Apoquel For Dogs.

Drug Interactions and Cautions

Use Simparica with caution in dogs with neurologic disease. Discuss all medicines, supplements, and preventives with a veterinarian. While no specific drug interaction is commonly highlighted, concurrent use with other isoxazoline products is not recommended.

If a dog has secondary skin infections from scratching, veterinarians may prescribe antibiotics. Learn more in Cephalexin For Dogs and Clavamox For Dogs. This information is general and not a substitute for veterinary advice.

What to Expect Over Time

Fleas start to die after dosing, and household flea pressure declines with continued monthly use. Fewer ticks should be found attached after exposure. Environmental sources can reintroduce fleas and ticks, so long-term prevention is important. Many dogs remain comfortable on a steady monthly schedule.

Compare With Alternatives

Some dogs benefit from a topical option instead of a chew. A monthly spot-on with broad parasite coverage, such as Revolution® For Dog, may suit dogs that dislike tablets. For fast, single-day flea knockdown, a short-acting oral like Capstar® For Dog can be used as directed by a veterinarian. Each product has different spectra, dosing intervals, and age/weight minimums.

Pricing and Access

See Canadian pricing for Simparica with US delivery from Canada. Compare sizes and check current cash-pay savings on different weight ranges. Browse more options in Pet Medications.

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Availability and Substitutions

Stock can vary by strength. If a specific chew size is unavailable, veterinarians may consider an alternative flea and tick product or plan a temporary substitution. Options may include a topical selamectin product, a fast-acting oral flea tablet, or a different monthly preventive. Do not substitute products without veterinarian guidance.

Patient Suitability and Cost Saving Tips

Good candidates are dogs 6 months or older that need reliable monthly flea and tick protection. Dogs with a history of seizures may not be ideal candidates and need careful risk–benefit discussions. Cats should not receive Simparica.

Cost tips include choosing the correct weight band to avoid waste, purchasing multi-month cartons when appropriate, and setting refill reminders. Maintain home and yard flea control to reduce reinfestation. A veterinarian can help tailor prevention to regional risks.

Questions to Ask Your Clinician

• Is Simparica appropriate for this dog’s age, weight, and health status?
• Which weight band is correct today, and when should it be adjusted?
• How long should prevention continue during flea and tick season here?
• What signs of adverse reactions should be monitored at home?
• Can Simparica be used along with the current heartworm preventive?
• How should sarcoptic mange be managed and rechecked over time?
• What is the plan if a dose is missed or vomited?

Authoritative Sources

• Zoetis Simparica Product Information
• FDA CVM Isoxazoline Safety Alert
• Health Canada Drug Product Database

Start an order for Simparica with US delivery from Canada. Always follow veterinary directions and the product label. This page is educational and is not a substitute for professional advice.