Spironolactone HCTZ Tablets for Hypertension and Edema

What Spironolactone HCTZ Is and How It Works

Spironolactone HCTZ combines two diuretics in one tablet for blood pressure and fluid control. Spironolactone is a potassium‑sparing aldosterone antagonist. Hydrochlorothiazide (HCTZ) is a thiazide diuretic. Together, they increase sodium and water excretion while helping maintain potassium. This product is taken by mouth, usually once daily, for hypertension and edema related to heart failure, liver cirrhosis, or kidney conditions. Many visitors compare Spironolactone HCTZ price and ask about access for Spironolactone HCTZ without insurance at checkout.

CanadianInsulin is a prescription referral service. Prescriptions are verified with your clinic, and orders are filled by licensed Canadian pharmacies.

Partner pharmacies are licensed and vetted, with authentic brand medications and generics across a broad selection at value‑focused pricing. Tablets are available in common strengths such as 25/25 mg and 50/50 mg. The once‑daily option simplifies dosing and may improve adherence compared with taking two separate pills.

Dosage and Usage

• Typical initiation: 25 mg/25 mg once daily for hypertension or edema. Titrate based on response and labs. Some patients may use 50/50 mg daily, or divide into two doses.
• Administration: Take at the same time each day. With food may help reduce stomach upset. Avoid late‑evening dosing to limit nighttime urination.
• Monitoring: Periodic serum potassium, sodium, creatinine, and blood pressure are recommended. More frequent checks may be needed in renal impairment or with interacting medicines.
• Potassium management: Avoid routine potassium supplements or salt substitutes that contain potassium unless directed. Spironolactone increases potassium retention.
• Missed dose: A missed dose can be taken when remembered the same day. If the next dose is near, skip the missed dose. Do not double doses.
• Tablet handling: Swallow tablets whole or split only if scored and advised by a pharmacist. Do not crush if a specific product is non‑scored or modified‑release.
• Drug interactions: Use caution with ACE inhibitors, ARBs, aliskiren, potassium supplements, NSAIDs, lithium, and strong diuretics. Periodic lab checks help reduce risk.
• Special populations: Dose adjustments and close monitoring may be required in the elderly, in hepatic or renal impairment, and in those with diabetes or gout.

• Storage: Store tablets at 20–25°C (68–77°F). Short excursions 15–30°C (59–86°F) are usually acceptable. Keep dry and protect from light.
• Packaging: Keep in the original labeled bottle with the desiccant, if provided. Close the cap tightly to limit moisture.
• Travel: Carry in your hand luggage with a copy of your prescription. Do not leave medicine in a hot car or near windows.
• Daily handling: Use a pill organizer if helpful, and keep a simple dosing log. Bring the bottle to appointments for reconciliation.
• Refills: Set reorder reminders so your supply arrives before you run out.

Benefits and Savings

This combination offers complementary diuretic action. HCTZ supports steady blood pressure reduction. Spironolactone counters HCTZ‑related potassium loss and offers added antihypertensive effect through aldosterone blockade. The single‑tablet approach reduces pill burden and may increase adherence. Flexible strengths allow titration for edema relief and hypertension control.

Many customers save 60–80% vs typical U.S. prices. Transparent options help those comparing costs, including patients purchasing Spironolactone HCTZ without insurance. See our promotions page for current offers, including any Spironolactone HCTZ coupon if available.

Side Effects and Safety

• Common: increased urination, dizziness or lightheadedness, low blood pressure, headache, fatigue.
• Electrolytes: hyperkalemia (from spironolactone), hyponatremia, or mild dehydration. Muscle cramps can occur with shifts in salts.
• GI: nausea, diarrhea, or abdominal discomfort; taking with food may help.
• Dermatologic: photosensitivity with HCTZ; use sun protection. Rash can occur.
• Endocrine/sexual: breast tenderness, menstrual irregularities, or decreased libido due to spironolactone’s antiandrogenic effect.
• Metabolic: thiazides can raise uric acid and may trigger gout in susceptible patients; they may also modestly affect glucose and lipids.

Serious but less common risks include clinically significant hyperkalemia, severe hyponatremia, kidney injury, symptomatic hypotension, pancreatitis, cholestatic jaundice, severe skin reactions (e.g., Stevens‑Johnson syndrome), and allergic reactions. Do not use in anuria, acute renal insufficiency, or known hyperkalemia. Avoid in Addison’s disease. Use caution with a history of sulfonamide hypersensitivity. Discuss pregnancy and lactation considerations with a clinician.

Onset Time

Blood pressure changes begin within several days, with clearer reductions within 1–2 weeks as diuretic effects stabilize. Full antihypertensive response may take 2–4 weeks after dose adjustments. Edema often improves over 2–3 days, with continued reduction across 1–2 weeks. Potassium effects from spironolactone tend to appear within the first week, so early lab checks are helpful during titration.

Compare With Alternatives

Some patients use a single agent such as Spironolactone when potassium conservation is the priority, adding a separate thiazide only if needed. Others choose an ACE inhibitor plus thiazide combination, such as Ramipril Hctz, to target the renin‑angiotensin system directly. An ARB‑plus‑thiazide option like Micardis Plus® (telmisartan/hydrochlorothiazide) is another pathway; see Micardis Plus for details. The optimal choice depends on clinical goals, tolerance, comorbidities, and lab trends.

The spironolactone/HCTZ combination can be useful when a thiazide is indicated but hypokalemia has occurred, or when edema control and potassium conservation are both desired. ACE‑ or ARB‑based combinations may be preferred for cardio‑renal outcomes in some patients, while calcium channel blockers can be paired separately with diuretics when vasodilation is needed with fewer metabolic effects.

Combination Therapy

• ACE inhibitor or ARB: May be used together but increases hyperkalemia risk. Background doses often need careful titration and more frequent potassium and creatinine checks.
• Loop diuretic: In refractory edema, adding a loop diuretic (e.g., furosemide) provides sequential nephron blockade. Close monitoring of volume status and electrolytes is essential.
• Calcium channel blocker: Commonly paired for additive BP lowering without increasing potassium. Useful when edema control and vasodilation are both desired.
• Beta blocker: May be combined in resistant hypertension or heart failure regimens. Observe for hypotension and adjust doses accordingly.
• Other agents: Use caution with lithium, NSAIDs, or high‑dose potassium. Review all medications and supplements for interactions.

Patient Suitability and Cost-Saving Tips

Suitable candidates often include adults with primary hypertension or edema from heart failure, liver cirrhosis with ascites, or certain kidney conditions. It may be chosen when potassium conservation is desired, or when HCTZ alone caused low potassium. Renal function and electrolytes should be appropriate for diuretic therapy before initiation.

Not suitable in anuria, acute kidney failure, known hyperkalemia, Addison’s disease, or hypersensitivity to spironolactone, thiazides, or sulfonamide derivatives. Use caution in significant renal impairment, hepatic dysfunction, gout, diabetes, or in the elderly. Discuss pregnancy intentions and breastfeeding with a clinician before starting therapy.

Cost‑saving ideas include selecting multi‑month quantities to reduce per‑unit cost and shipping frequency, choosing the strength that matches the prescribed daily dose to avoid tablet splitting waste, and bundling prescriptions in one order when possible. Setting gentle reorder reminders helps maintain continuity so treatment is not interrupted while waiting for delivery. CanadianInsulin offers prompt, express, cold‑chain shipping.

Authoritative Sources

DailyMed: Spironolactone and Hydrochlorothiazide Tablets

Health Canada Drug Product Database (DPD)

FDA Label: Aldactazide (spironolactone and hydrochlorothiazide)

Order Spironolactone HCTZ from CanadianInsulin: add to cart, upload your prescription, and we ship with prompt, express, cold‑chain handling.

This page is educational and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider about any questions regarding a medical condition or medication.