Spironolactone HCTZ (spironolactone/hydrochlorothiazide)

Spironolactone HCTZ is a prescription combination diuretic used in selected patients for fluid retention and high blood pressure. This page explains Spironolactone HCTZ price considerations, dosing basics, and safety topics to review with a prescriber. CanadianInsulin supports US shipping from Canada with cash-pay access for people without insurance.

What Spironolactone HCTZ Is and How It Works

Spironolactone HCTZ combines two medicines that affect fluid balance and blood pressure. Spironolactone is an aldosterone antagonist (a hormone blocker that helps the body retain less salt and water) and is considered “potassium-sparing,” meaning it can raise potassium in some patients. Hydrochlorothiazide (HCTZ) is a thiazide diuretic (water pill) that increases urine output and can lower blood pressure.

By pairing these actions, the combination may reduce swelling (edema) and help control blood pressure when a clinician decides a single agent is not adequate. It is often discussed in the context of cardiovascular conditions; the Cardiovascular Category is a browseable list of related therapies. Licensed Canadian pharmacies dispense medications for approved referrals.

Why it matters: The combination can shift electrolytes, so lab monitoring is commonly part of safe use.

Some patients will see this combination referred to as spironolactone and hydrochlorothiazide tablets or by a brand name such as Aldactazide. Brand and generic options can differ by market, and not every prescriber uses the same naming conventions. For general background on heart and blood pressure topics, the Cardiovascular Articles hub collects condition-focused reading.

Who It’s For

This combination is prescribed for certain people who need both a diuretic effect and aldosterone blocking. Common reasons discussed on labeling include edema related to heart failure, liver disease (such as cirrhosis), or kidney disorders that cause fluid retention, as well as hypertension when appropriate. Condition hubs such as the Hypertension Hub and Heart Failure Hub can help organize related medications and topics.

It is not appropriate for everyone. Clinicians typically avoid use in patients with anuria (unable to make urine), some forms of severe kidney impairment, or known hyperkalemia (high potassium). Caution is also common in people with significant liver disease, dehydration, or a history of gout, because thiazide diuretics can affect uric acid. When comparing Spironolactone HCTZ price across sources, eligibility and safety screening remain the primary step, since the medicine still requires a valid prescription.

Allergies and special situations matter. Hydrochlorothiazide is a sulfonamide-derived drug, so a history of severe sulfa reactions should be discussed with the prescriber. Pregnancy and breastfeeding considerations should also be reviewed using the official labeling and the patient’s clinical context, since diuretics and hormone-active drugs may not be appropriate in some circumstances.

Dosage and Usage

Spironolactone HCTZ is taken by mouth as directed on the prescription label. Dosing schedules vary by indication, kidney function, age, and other medicines, so only a prescriber can set an individualized plan. Some regimens are once daily, while others are divided into more than one dose, particularly when fluid status is being closely managed.

Because it increases urination, clinicians often consider timing to reduce nighttime bathroom trips, but directions should follow the written prescription. The therapy may be taken with or without food depending on the product labeling and the patient’s tolerance. Missed-dose instructions differ among products; patients are typically advised to follow the label guidance and contact a pharmacist if unsure.

For broader context on blood pressure treatment approaches, the guides Bystolic Blood Pressure Guide and Atenolol And Hypertension describe how other medication classes may be used alongside diuretics. Documenting the prescribed directions can also help when reviewing Spironolactone HCTZ price changes between refills.

Strengths and Forms

This medicine is most commonly supplied as oral tablets that contain a fixed-dose combination of spironolactone and hydrochlorothiazide. In some markets it may be referred to as spironolactone hydrochlorothiazide generic, including references to “generic Aldactazide.” Final appearance, imprint, and packaging depend on the dispensing pharmacy and manufacturer.

Common fixed-dose combinations prescribed in practice include spironolactone hctz 25 mg/25 mg and spironolactone hctz 50 mg/50 mg. Availability can vary, and prescribers may adjust strength based on clinical goals and laboratory results. Strength selection can influence Spironolactone HCTZ price and the number of tablets supplied.

Pharmacies may dispense different pack sizes depending on the prescription and local standards, including quantities often written as 30 or 90 tablets. When a prescriber writes for maintenance therapy, the prescription may specify a longer supply to reduce refill frequency, but the dispensed quantity still depends on authorization and applicable rules.

Storage and Travel Basics

Spironolactone HCTZ tablets are typically stored at controlled room temperature in a dry place, protected from excessive heat and moisture. Keeping the medicine in its original, labeled container helps reduce mix-ups and preserves key details such as the lot number and expiration date. Bathrooms and kitchens can be humid, so storage locations with consistent temperature are generally preferred.

When traveling, carrying the medicine in hand luggage can reduce exposure to temperature extremes. Patients often find it helpful to keep a current medication list and the dispensing label available, especially if care is needed away from home. Any visible changes in tablet appearance should be confirmed with a pharmacist before use, since manufacturers and imprints can differ between refills.

Some patients using diuretics are also treated for heart failure. For background on that condition and how different classes are used, see What Entresto Is Used For as a broader education resource.

Side Effects and Safety

Side effects may reflect both components of the combination. Hydrochlorothiazide can cause increased urination, dizziness (especially when standing), headache, nausea, and changes in electrolytes such as low sodium or low potassium. Spironolactone can cause gastrointestinal upset and may contribute to high potassium. Because spironolactone affects hormone pathways, some patients report breast tenderness or menstrual changes. Side-effect monitoring matters regardless of Spironolactone HCTZ price.

More serious reactions are less common but require attention. These can include severe weakness, fainting, irregular heartbeat, confusion, or signs of significant dehydration. Allergic reactions (such as rash, swelling, or breathing difficulty) require urgent evaluation. Hydrochlorothiazide has also been associated with photosensitivity (increased sensitivity to sunlight) in some patients.

Quick tip: Keeping a sun-protective routine can be useful when a medicine causes photosensitivity.

Monitoring and red flags

Prescribers commonly monitor blood pressure, kidney function, and electrolytes while patients take this combination, especially after starting or changing the dose. Potassium is a key focus because spironolactone can raise it, while thiazides can lower it. Weight tracking may also be used as a practical proxy for fluid status in some conditions. Symptoms that may warrant prompt clinical review include severe muscle cramps, marked fatigue, palpitations, very low urine output, persistent vomiting, or sudden swelling. The safest monitoring schedule depends on diagnosis and comorbidities.

People with diabetes or gout may need closer follow-up. Thiazide diuretics can affect blood sugar and uric acid levels, and medication adjustments may be needed based on laboratory findings. Patients should rely on the official prescribing information and clinician guidance rather than making unsupervised changes.

Drug Interactions and Cautions

Many interactions relate to potassium and kidney function. Combining spironolactone with potassium supplements, salt substitutes containing potassium, or other potassium-sparing diuretics can increase the risk of hyperkalemia. ACE inhibitors and ARBs (common blood pressure medicines) can also raise potassium, so clinicians often plan lab checks when these are used together.

• Potassium-raising therapies: higher hyperkalemia risk
• NSAIDs: may reduce diuretic effect, strain kidneys
• Lithium: lithium levels can increase
• Digoxin: electrolyte shifts may affect safety
• Other diuretics: additive fluid and electrolyte changes

Prescriptions may be checked with the prescriber when needed. Patients should also tell clinicians about over-the-counter pain relievers, supplements, and any recent vomiting or diarrhea, since dehydration can worsen side effects. For additional reading on therapies used in heart failure management, see SGLT2 Inhibitors Heart Failure.

Alcohol and other medicines that lower blood pressure can increase dizziness in some patients. Photosensitivity precautions may also be discussed with hydrochlorothiazide-containing products. When more than one clinician is prescribing medications, maintaining an up-to-date list helps prevent unintentional duplication.

Compare With Alternatives

Spironolactone HCTZ is one way to combine a potassium-sparing diuretic with a thiazide diuretic. Alternatives may include prescribing the two components separately, which can allow more flexible titration. Some patients are treated with other diuretic classes (for example, loop diuretics) when fluid overload is significant, or with non-diuretic blood pressure medicines when edema is not the main issue.

For reference, CanadianInsulin also lists the single agents Spironolactone Details and Hydrochlorothiazide Details. These are not substitutes for clinical decision-making, but they can help patients understand how combination therapy differs from single-ingredient options.

Comparisons can clarify benefits beyond Spironolactone HCTZ price. Clinicians may consider kidney function, potassium history, other cardiovascular drugs, and how quickly fluid status needs to change. Some patients also need additional therapies for the underlying condition, such as guideline-directed heart failure medications or lifestyle measures, and the diuretic plan is only one part of treatment.

Spironolactone HCTZ price and Access

Access to this medication requires a valid prescription. CanadianInsulin operates as a prescription referral platform that coordinates documentation and routes eligible orders to a licensed Canadian pharmacy for dispensing. The final out-of-pocket amount can vary based on strength, tablet quantity, and dispensing pharmacy, so it helps to review the prescription details carefully before checkout.

For patients paying cash or managing spironolactone hctz without insurance, it may be useful to compare different tablet quantities (such as maintenance vs shorter supplies) and ask the prescriber whether the written directions match current clinical goals. Cash-pay access is available for qualifying prescriptions.

To check current site-wide programs, visit the Promotions Page. Refill timing depends on the prescription authorization, and some refills require updated prescriber confirmation based on local requirements and clinical context.

Authoritative Sources

For the full prescribing information and safety details, consult the official labeling.

Read U.S. label details via DailyMed spironolactone hydrochlorothiazide listings.

Search approved products and labeling at FDA Drugs@FDA database.

For checkout and fulfillment questions, customer support can explain prompt, express, cold-chain shipping when required.

This content is for informational purposes only and is not a substitute for professional medical advice.