Xenical® (Orlistat) 120 mg Capsules for Weight Management

What Xenical® Is and How It Works

Xenical® contains orlistat, a lipase inhibitor for chronic weight management. It works in the gut, not the bloodstream. Orlistat blocks about 25–30% of dietary fat from being absorbed, so calories from fat pass through the stool. Many patients start when diet and activity alone have not met goals. Some visitors compare options, read dosing, and then buy orlistat online through our service.

CanadianInsulin is a prescription referral service. Prescriptions are verified with your clinic, and orders are filled by licensed Canadian pharmacies. We work with vetted partners to source authentic brand medications with a broad selection and value-focused pricing.

Xenical is prescription strength orlistat 120 mg. It is taken with each main fat-containing meal. It supports reduced-calorie diets for adults with obesity, or for those overweight with risk factors such as type 2 diabetes, dyslipidemia, or hypertension. Effects are local to the gastrointestinal tract and do not suppress appetite.

Dosage and Usage

• Start: 120 mg capsule by mouth three times daily with each main fat-containing meal.
• Meals: Take during the meal or within 1 hour after eating. Skip the dose if the meal is skipped or contains no fat.
• Diet: Pair with a reduced-calorie diet where fat provides about 30% of daily calories, spread across three meals.
• Vitamins: Take a multivitamin with fat‑soluble vitamins (A, D, E, K) at bedtime or at least 2 hours after orlistat.
• Drug spacing: Separate from cyclosporine by at least 3 hours. Separate from levothyroxine by at least 4 hours; monitor thyroid labs as advised.
• Missed dose: If more than 1 hour has passed since a fat‑containing meal, skip and resume with the next appropriate meal. Do not double up.
• Swallow capsules whole with water. Do not crush or chew.
• Continue lifestyle measures. Monitor weight, waist, and relevant labs periodically per clinician guidance.

• Storage: Keep capsules at 15–30°C (59–86°F) in a dry place. Protect from moisture and light. Keep the desiccant in the bottle.
• Container: Store in the original, tightly closed container. Do not freeze. Do not use if the seal is broken.
• Travel: Carry in hand luggage with the labeled prescription. Avoid heat, dashboards, and checked baggage extremes.
• Short trips: Keep between 15–30°C. Limit exposure to humidity. Use a small dry pouch if climates are humid.
• Household safety: Keep out of reach of children and pets. Do not store in bathrooms.

Benefits and Savings

Xenical can support clinically meaningful weight reduction when combined with a reduced‑calorie diet. Average loss often begins within weeks and may continue over several months. Benefits can include modest improvements in blood pressure, lipids, and glycemic measures in individuals with type 2 diabetes or prediabetes.

Orlistat works locally in the gut and is not a stimulant. It is non‑systemic, so it generally avoids effects on heart rate or blood pressure. The capsule format is familiar, and dosing aligns with typical meal patterns.

Many customers save 60–80% vs typical U.S. prices.

People who wish to buy xenical online often compare brand and generic options, review orlistat 120 mg price ranges, and select multi‑month supplies to reduce per‑unit cost.

Side Effects and Safety

• Very common: oily spotting, gas with discharge, urgent or increased bowel movements, fatty/oily stools, soft stools.
• Common: abdominal discomfort, fecal incontinence, oily evacuation, rectal pain, nausea.
• Possible: decreased absorption of fat‑soluble vitamins; take a multivitamin at a different time of day.
• Interactions: cyclosporine, levothyroxine (dose separation needed), warfarin (monitor INR), some antiepileptics (monitor seizure control).

Serious but less common risks include severe liver injury (seek care for jaundice, dark urine, pruritus, right‑upper‑quadrant pain), oxalate nephropathy and kidney stones, and rare hypersensitivity reactions. Do not use in chronic malabsorption syndrome, cholestasis, or pregnancy. For further reading, see Xenical Side Effects And How To Manage Them.

Onset Time

Fat blocking begins with the first dose, and fecal fat increases within 24–48 hours. Early weight changes may appear in about 2 weeks. Most weight loss typically occurs over 3–6 months as diet and dosing stabilize. Metabolic measures such as A1C and fasting glucose may improve over 1–3 months when weight decreases. Lipid changes can be seen within 2–3 months. Weight usually plateaus by 6–12 months; maintenance requires ongoing diet and activity.

Compare With Alternatives

Wegovy® (semaglutide) is a once‑weekly GLP‑1 injection approved for chronic weight management. It reduces appetite and caloric intake and often produces larger average weight loss than orlistat, but it is an injectable and has different side effect and monitoring needs. For background, read Wegovy Vs Mounjaro How These Weight Loss Drugs Work.

Rybelsus® (oral semaglutide), Trulicity® (dulaglutide), and Mounjaro® (tirzepatide) are GLP‑1 or GIP/GLP‑1 agents approved for type 2 diabetes treatment. They often support weight reduction as a treatment effect in diabetes. They act systemically and differ from orlistat’s gastrointestinal mechanism.

Choice depends on goals, comorbidities, route preference, tolerability, and access. Orlistat may suit those seeking a non‑systemic, oral option focused on dietary fat blocking, while GLP‑1 agents may be considered when broader metabolic effects or larger average weight changes are desired.

Combination Therapy

• With metformin or SGLT2 inhibitors: commonly combined in type 2 diabetes management; monitor glycemia and hydration.
• With insulin or sulfonylureas: orlistat does not cause hypoglycemia alone, but background doses may need adjustment to reduce hypoglycemia risk.
• With antihypertensives or statins: often used in patients with cardiometabolic risks. For hypertension therapies, see Ramipril or Losartan as examples.
• With multivitamins: separate dosing to maintain fat‑soluble vitamin levels.

Patient Suitability and Cost‑Saving Tips

Candidates include adults with a body mass index (BMI) ≥30 kg/m², or ≥27 kg/m² with comorbidities such as type 2 diabetes, dyslipidemia, or hypertension. Some adolescents may be prescribed orlistat under clinician supervision. It is not for pregnancy or breastfeeding, chronic malabsorption, or cholestasis.

Caution is advised in a history of kidney stones, significant gastrointestinal disease, or after organ transplant (due to cyclosporine interaction). Review current medications for interactions and monitoring. Explore related guidance in our Obesity and Weight Management sections.

Cost‑saving ideas include choosing multi‑month supplies when appropriate, comparing brand and generic orlistat options, and aligning refills to reduce shipping events. Many customers look at orlistat 120 mg price differences by pack size and plan ahead to avoid gaps in therapy.

Authoritative Sources

FDA Prescribing Information for Orlistat (Xenical)

Health Canada Drug Product Database: Xenical (orlistat)

Manufacturer Information (Hoffmann-La Roche)

Order Xenical® from CanadianInsulin: add to cart, upload your prescription, and we ship with prompt, express, cold‑chain handling.

This material is for educational purposes only and does not replace advice from your healthcare professional. Always follow your prescriber’s instructions and the medication guide.