Weight loss can be incredibly challenging, especially for individuals dealing with obesity or other metabolic issues. While lifestyle changes remain the foundation of a healthier body, some people need additional support. That’s where weight loss injections come in. If you’ve been researching injectable options, you’ve likely come across Saxenda and Wegovy.

Both are FDA-approved prescription medications that help reduce appetite and control weight. But how do they work, and what sets them apart? In this guide, we’ll break down the differences involving Saxenda vs Wegovy, including their effectiveness, side effects, usage, and even cost.

Understanding the Role of Weight Loss Injections

Weight loss shots like Saxenda and Wegovy belong to a newer class of medications that mimic hormones naturally found in the body. These hormones help regulate appetite, blood sugar, and digestion—key components in effective long-term weight control.

People who have struggled to lose weight with diet and exercise alone may benefit from weight loss injections. These treatments are particularly useful for those who have underlying health issues such as type 2 diabetes or metabolic syndrome.

What Is the Best Injection for Weight Loss?

The answer isn’t one-size-fits-all. It depends on your medical history, weight loss goals, and how your body responds to the medication. However, Saxenda and Wegovy are two of the most commonly prescribed and most widely studied options available today.

Both medications are part of the GLP-1 receptor agonist family. This means they work by mimicking a hormone that helps control blood sugar and appetite. While their mechanisms are similar, their dosages, formulations, and clinical outcomes vary—leading to some distinct differences between them.

Saxenda vs Wegovy: Key Differences

To better understand the comparison of Saxenda vs Wegovy, let’s look at how they differ across a few important categories:

1. Active Ingredient

Saxenda uses liraglutide, while Wegovy uses semaglutide, which is also used in some diabetes medications but at a lower dose.

Semaglutide is generally considered more potent than liraglutide, which may impact the overall weight loss results.

2. Dosage Frequency

Saxenda is injected daily, while Wegovy is injected once a week.

This difference in convenience could influence patient preference and adherence.

3. Effectiveness

Clinical trials show that people using Wegovy lost an average of 15% of their body weight, while those on Saxenda lost around 8%. So, in terms of pure numbers, Wegovy tends to produce greater results.

 4. Side Effects

Common side reactions for both include nausea, diarrhea, constipation, and headaches. However, because semaglutide (Wegovy) is stronger, some people experience more intense symptoms during the first few weeks of treatment. 

5. FDA Approval and Use

Saxenda is approved for adults and some adolescents with obesity, while Wegovy is approved for adults with obesity or overweight individuals with weight-related conditions. 

Saxenda vs Wegovy Price

Cost is another major factor when considering Saxenda vs Wegovy. Without insurance, both can be quite expensive. Monthly prices vary, but in general, Wegovy tends to be slightly pricier due to its newer formulation and higher efficacy rates.

Here’s a quick breakdown:

• Saxenda typically costs around $1,300/month.
• Wegovy can cost up to $1,400/month.

However, coverage varies significantly depending on insurance plans and pharmacy discounts, so it’s worth checking with your provider or using savings cards offered by the manufacturers.

How to Choose the Right Weight Loss Shot for You

The decision between these two weight loss medications should be made in collaboration with your healthcare provider. Consider your personal goals, medical history, lifestyle, and your willingness to stick with either a daily or weekly routine.

1. Consider Your Weight Loss Goals 

If your goal is significant weight loss and you’re comfortable with weekly injections, Wegovy might be the better fit. 

2. Look at Your Medical Conditions

People with certain conditions (like a history of pancreatitis or thyroid tumors) should avoid GLP-1 agonists. Always review your health profile with your doctor first. 

3. Be Realistic About Routine

Daily injections may be manageable for some, while others may prefer the convenience of a once-weekly dose. 

Monitoring Progress and Staying Consistent

Whichever medication you choose, consistency and regular monitoring are essential. Most people see noticeable results within the first 12–16 weeks of use, especially when paired with lifestyle changes.

In addition to the shot, adopting healthier habits—like balanced meals, regular activity, and proper hydration—can significantly amplify your results. Think of these injections as one part of a full plan, not a miracle fix.

Where to Learn More About Weight Loss Medication Options 

If you’re exploring prescription support for weight loss, understanding your medication choices is key. You can learn more about these treatments, such as Saxenda and Wegovy, on our dedicated Weight Loss Category Page, designed to help you make informed decisions. 

Achieving your weight goals isn’t just about injections; consistent habits, balanced nutrition, and ongoing support from your healthcare provider all play a role in long-term success.

Takeaways

Choosing between Saxenda vs Wegovy ultimately comes down to your personal preferences and health goals. While Wegovy tends to show more significant weight loss results and requires less frequent dosing, Saxenda remains a proven option—especially for those who are fine with daily injections.

Both weight loss injections can offer meaningful support when lifestyle changes alone aren’t enough. Take time to talk to your doctor about side effects, expected outcomes, and the Saxenda vs Wegovy price difference to make a well-informed decision.

Frequently Asked Questions (FAQs)

What is the best injection for weight loss?

It depends on the individual. Wegovy often leads to greater weight loss, but Saxenda is also effective, especially for those who prefer a daily injection schedule.

Are weight loss shots safe? 

Yes, both Saxenda and Wegovy are FDA-approved and considered safe for most people. However, they may cause gastrointestinal side effects, especially in the early stages of treatment. 

Can I get insurance to cover these medications?

Coverage varies. While some insurance plans include these medications, others do not. Always check with your insurance provider to see which options are covered under your plan.