Acevet 25 Injectable® for Veterinary Sedation and Tranquilization

What Acevet® 25 Injectable Is and How It Works

Acevet 25 Injectable is a veterinary tranquilizer for dogs, cats, and horses. It contains acepromazine maleate in a 25 mg/mL injectable solution. This phenothiazine agent helps provide sedation and chemical restraint for handling, pre‑anesthetic use, and transport. Many customers look for Acevet 25 without insurance to reduce out‑of‑pocket costs while maintaining access to an established option for animal calming.

CanadianInsulin is a prescription referral service. Prescriptions are verified with your clinic, and orders are filled by licensed Canadian pharmacies. We partner with vetted pharmacies to supply authentic brands and value‑focused pricing across a broad selection.

Acepromazine acts mainly by dopamine (D2) antagonism in the central nervous system. It also blocks peripheral alpha‑1 receptors, which can lower blood pressure through vasodilation. It does not provide pain relief, so it is often combined with analgesics for procedures. Routes include intramuscular (IM) and intravenous (IV) administration, as directed by a veterinarian. Sedation depth varies by species, dose, and the patient’s health status.

Dosage and Usage

• Use only under a veterinarian’s direction for the prescribed animal and indication.
• Confirm concentration (25 mg/mL) and prescribed volume before preparation.
• Administration routes: IM or IV, per veterinary guidance. Subcutaneous use may be limited by local policy.
• For IV use, administration is performed by trained personnel to reduce adverse effects.
• For IM injections, typical sites include the thigh or epaxial muscles in small animals; the neck or hindquarters in horses.
• Observe the patient in a quiet setting. Allow adequate time for onset before handling or procedures.
• Pre‑anesthetic protocols often combine acepromazine with opioids or other sedatives. Follow clinic instructions.
• Missed timing for a scheduled pre‑procedure dose: contact the clinic for next steps. Do not repeat or increase without guidance.
• Do not use in animals with shock, severe dehydration, or significant cardiovascular compromise unless directed by a veterinarian.

• Storage: keep at controlled room temperature (about 15–25°C/59–77°F). Protect from light.
• Do not freeze. Avoid excessive heat or direct sunlight during storage.
• Use sterile technique for each puncture of the stopper. Discard if contamination is suspected.
• Follow the labeled or clinic‑provided beyond‑use date after first puncture. Many multi‑dose vials are discarded within 28 days.
• Travel: keep in the original carton to limit light exposure. Pack upright and cushioned.
• During transit or clinic visits, carry supplies (syringes/needles) as instructed by the veterinarian.
• Do not use if the solution is discolored, contains particles, or the seal is compromised.

Benefits and Savings

Acevet 25 Injectable offers reliable tranquilization for handling and procedural preparation. It allows calmer examinations, imaging, minor procedures, and safer transport in appropriate patients. Flexible routes (IM or IV) support clinic protocols. When paired with analgesics, it can reduce the amount of other anesthetic agents needed.

Veterinarians value its predictable onset and duration in many dogs, cats, and horses. It is a long‑standing option with extensive clinical use history. Many clinics use it in balanced protocols to reach desired sedation while maintaining procedure efficiency.

Many customers save 60–80% vs typical U.S. prices. Paying without insurance is common for pet medications; final cost varies by vial size and quantity. See our promotions page for current offers, including any Acevet 25 promo if available.

Side Effects and Safety

• Common: sedation, decreased activity, incoordination, and third eyelid protrusion (nictitating membrane).
• Cardiovascular: hypotension from alpha‑1 blockade; possible bradycardia or reflex tachycardia.
• Gastrointestinal: occasional vomiting or reduced gastrointestinal motility.
• Thermoregulation: hypothermia in cool environments; monitor temperature in small or debilitated patients.
• Hematologic: splenic enlargement may occur; consider when interpreting abdominal imaging.
• Behavioral: rare paradoxical excitement or agitation, especially with inadequate dosing or stress.
• Equine: risk of penile prolapse/paraphimosis in stallions; avoid in breeding stallions.

Serious reactions are uncommon but can include marked hypotension, collapse, or allergic responses. Use caution in patients with liver disease, significant anemia, dehydration, shock, or cardiovascular compromise. Discuss seizure history with the veterinarian. Interactions may occur with other CNS depressants, antihypertensives, and organophosphate compounds. Monitor closely when combined with opioids, alpha‑2 agonists, or inhalant anesthetics.

Onset Time

IM administration often begins to calm dogs and cats within 15–60 minutes. IV administration usually acts faster, often within 10–20 minutes in clinical settings. Horses may show sedation within about 15 minutes IV and 30–45 minutes IM. Peak effect is commonly reached within 30–60 minutes, with tranquilization lasting several hours depending on dose, species, and concurrent medications.

Compare With Alternatives

Acepromazine injection is one option among several veterinary sedatives. Dexmedetomidine (an alpha‑2 agonist) produces deeper, more controllable sedation and is reversible with atipamezole. It may cause bradycardia and blood pressure changes, so monitoring is standard. Butorphanol (an opioid agonist‑antagonist) offers sedation plus short‑acting analgesia and is often paired with acepromazine for minor procedures.

Oral acepromazine tablets are sometimes used for at‑home pre‑visit sedation or transport. Tablets have a slower onset and more variable absorption compared with injectable forms. Selection depends on the patient’s health, procedure needs, monitoring availability, and the veterinarian’s protocol. Combining classes can improve comfort and reduce doses of individual drugs.

Combination Therapy

• Acepromazine plus an opioid (e.g., butorphanol) to add sedation and short‑acting analgesia.
• Acepromazine plus an alpha‑2 agonist (e.g., dexmedetomidine) for deeper sedation in clinic settings.
• Acepromazine within a balanced pre‑anesthetic regimen to reduce inhalant or induction agent requirements.
• When combining CNS depressants, veterinary teams often adjust doses to limit hypotension and respiratory depression.
• Local or regional anesthesia can be added for procedural pain control without increasing systemic sedative load.

Patient Suitability and Cost‑Saving Tips

This medication may suit healthy adult dogs, cats, and horses needing tranquilization or pre‑anesthetic calming. Lower starting doses are often chosen for small, geriatric, or debilitated patients. Animals with severe cardiovascular disease, shock, dehydration, marked anemia, or significant hepatic impairment may not be good candidates. Genetic sensitivity has been noted in some herding breeds; veterinarians may adjust doses accordingly. Avoid use in breeding stallions due to penile prolapse risk.

Cost‑saving ideas include consolidating prescriptions in one order, selecting multi‑vial quantities when appropriate, and scheduling refills before planned procedures or travel. Discuss the most efficient vial size with the clinic to reduce waste after first puncture. CanadianInsulin ships with prompt, express, cold‑chain handling, helping maintain product integrity from our licensed partners.

Authoritative Sources

Merck Veterinary Manual: Phenothiazine tranquilizers (acepromazine)

Health Canada Drug Product Database: Veterinary listings

FDA Animal Drugs @ FDA: Acepromazine listings

Order Acevet 25 Injectable from CanadianInsulin: add to cart, upload your prescription, and we ship with prompt, express, cold‑chain handling.

This page is educational and does not replace advice from a licensed veterinarian. Always follow the prescribing veterinarian’s directions for use, monitoring, and follow‑up.