Eliquis® (Apixaban) Tablets for Blood Clots and Atrial Fibrillation

What Apixaban Is and How It Works

Apixaban is an oral anticoagulant used to prevent and treat blood clots. It contains the same active ingredient found in Eliquis®. From Canada, it ships to the US with US delivery from Canada and Canadian pricing, which many shoppers compare for savings without insurance.

Apixaban is a direct oral anticoagulant (DOAC) that selectively inhibits Factor Xa. By blocking Factor Xa, it reduces thrombin generation and the formation of fibrin clots. Learn more about clinical roles and labeled uses in Apixaban Uses.

At CanadianInsulin, orders are filled by licensed Canadian pharmacies after we confirm a valid prescription with your clinic.

Who Apixaban Is For

Apixaban is prescribed for adults to reduce the risk of stroke and systemic embolism in nonvalvular atrial fibrillation. It treats deep vein thrombosis (DVT) and pulmonary embolism (PE), and helps prevent recurrent DVT/PE after initial therapy. It also helps prevent DVT after hip or knee replacement surgery. For related information, see Atrial Fibrillation and Pulmonary Embolism.

It is not for patients with active pathological bleeding or those with mechanical heart valves. Use requires caution in severe hepatic impairment and with certain drug interactions. Clinicians weigh bleeding risk, renal and hepatic function, age, and procedure plans when deciding if apixaban is appropriate.

Dosage and Usage

Dosing is individualized by the prescriber. Typical labeled schedules include:

• Nonvalvular atrial fibrillation: 5 mg by mouth twice daily. Some adults use 2.5 mg twice daily when specific clinical factors apply, as determined by the prescriber.
• Treatment of DVT/PE: 10 mg by mouth twice daily for 7 days, then 5 mg twice daily thereafter.
• Reduction in risk of recurrent DVT/PE following initial treatment: 2.5 mg by mouth twice daily.
• Prophylaxis of DVT after hip or knee replacement: 2.5 mg by mouth twice daily, starting as directed post-surgery for a defined course.

Apixaban can be taken with or without food. For practical guidance on dosing principles, review Eliquis Dosing. When uncertain, follow the official label and clinician direction.

Strengths and Forms

Film-coated oral tablets in commonly available strengths:

• 2.5 mg tablets
• 5 mg tablets

Availability can vary by manufacturer and pack size.

Missed Dose and Timing

If a dose is missed, take it as soon as remembered on the same day, then resume the regular schedule. Do not double up doses at one time to make up for a missed dose. Keep doses as evenly spaced as possible, since apixaban is usually taken twice daily.

Storage and Travel Basics

Store tablets at room temperature, typically 20 to 25°C (68 to 77°F). Keep them dry, in the original container, and out of reach of children and pets.

When traveling, keep your medicine in carry-on baggage, along with a copy of your prescription. Pack enough tablets for the full trip plus a buffer. Maintain the twice-daily timing as closely as practical across time zones.

Benefits

• Proven anticoagulation for the prevention and treatment of blood clots in labeled uses.
• Oral dosing without routine INR monitoring.
• Predictable effect and fixed dosing in most adults.
• Fewer food restrictions than vitamin K antagonists like warfarin.

Side Effects and Safety

• Bleeding, including nosebleeds or gum bleeding
• Bruising
• Anemia
• Nausea
• Minor bleeding after cuts or dental care
• Rash or mild hypersensitivity

Serious risks include major bleeding and, rarely, intracranial hemorrhage. Premature discontinuation can increase the risk of thrombotic events. Spinal/epidural hematomas may occur in patients receiving neuraxial anesthesia or spinal puncture. Seek urgent care for signs of severe bleeding, weakness on one side, sudden severe headache, or black stools. For a deeper dive into reactions and precautions, see Apixaban Side Effects.

Drug Interactions and Cautions

• Strong dual inhibitors of CYP3A4 and P-gp (for example, ketoconazole, itraconazole, ritonavir): may increase bleeding risk.
• Strong inducers of CYP3A4 and P-gp (for example, rifampin, carbamazepine, phenytoin, St. John's wort): may reduce effectiveness.
• Other anticoagulants or thrombolytics: increased bleeding risk unless specifically directed.
• Antiplatelet agents and NSAIDs: additive bleeding risk.
• SSRIs/SNRIs: may increase bleeding tendency.
• Significant liver disease: use requires careful assessment.

Always provide a full medication and supplement list to the prescriber and pharmacist. Do not start or stop interacting medicines without professional guidance.

What to Expect Over Time

In atrial fibrillation, apixaban provides ongoing stroke risk reduction while it is taken as prescribed. In DVT/PE, symptoms often improve after the first days to weeks of therapy, but duration of treatment varies. Because the effect wears off within about a day of stopping, consistent adherence is important. Clinicians reassess clot and bleeding risks over time and adjust therapy plans as needed.

Compare With Alternatives

Other approved anticoagulants include rivaroxaban and dabigatran. Many adults use Xarelto® (rivaroxaban) once daily for certain indications. Some may use Pradaxa® (dabigatran), a direct thrombin inhibitor. Warfarin is an older vitamin K antagonist that remains appropriate for select patients, including those with certain valve types or cost considerations. The choice depends on indication, renal and hepatic function, interactions, and clinician judgment.

Pricing and Access

CanadianInsulin offers Canadian pricing with US delivery from Canada for apixaban. Many visitors compare apixaban cost and Apixaban price Canadian pricing across strengths before ordering. People often review Apixaban 5 mg price from Canada, Apixaban 2.5 mg price ships to US, and Apixaban 5 mg tablet price US shipping. Others look at Apixaban cost per month from Canada, Generic apixaban cost ships to US, and Apixaban price cash price from Canada to plan budgets. See current pricing on this page and proceed through encrypted checkout when ready.

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Availability and Substitutions

If a specific strength, pack size, or manufacturer is temporarily unavailable, a prescriber may recommend an appropriate alternative. Options can include rivaroxaban, dabigatran, or warfarin, depending on the clinical situation and access.

Patient Suitability and Cost Saving Tips

Adults with nonvalvular atrial fibrillation, recent DVT/PE, or post–hip or knee replacement may be candidates when bleeding risk is acceptable. Those with active bleeding, mechanical heart valves, or certain severe liver conditions generally should not receive apixaban. Prescribers also consider renal function, age, weight, and procedural plans.

To help manage cost, consider multi-month quantities when appropriate, since fewer shipments can lower overall fees. Set refill reminders, and keep a consistent routine for twice-daily dosing. If travel is planned, order early to ensure supply continuity with prompt, express shipping from Canada.

Questions to Ask Your Clinician

• Which apixaban dose is appropriate for my indication and clinical factors?
• How long is treatment expected for my condition?
• Which warning signs of bleeding should prompt urgent attention?
• Are any of my current medicines or supplements high risk with apixaban?
• What is the plan around surgery, dental work, or spinal procedures?
• Is apixaban suitable if liver or kidney function changes?
• How does apixaban compare with other DOACs or with warfarin for my goals?

Authoritative Sources

• Eliquis US Prescribing Information
• DailyMed: Apixaban
• Health Canada DPD: Apixaban

Start your apixaban order today for US delivery from Canada at Canadian pricing.