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Ezetimibe

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Use of Ezetimibe

Ezetimibe is a medication used to lower cholesterol levels in the blood, particularly low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol. By inhibiting the absorption of cholesterol from the diet and reducing its uptake from the intestines, Ezetimibe helps to decrease overall cholesterol levels, thereby reducing the risk of cardiovascular diseases such as heart attacks and strokes.

Mechanism of Action

Ezetimibe works by inhibiting the activity of a protein called NPC1L1 (Niemann-Pick C1-Like 1) located on the surface of cells in the small intestine. This protein plays a crucial role in the absorption of cholesterol from the diet into the bloodstream. By blocking NPC1L1, Ezetimibe prevents the uptake of cholesterol from the intestines, leading to a decrease in cholesterol levels in the blood.

Precautions and Warnings

Before adding Ezetimibe into your medication, you should first take note of the following precaution to ensure safety:

  • Inform your healthcare provider about any history of liver disease or unexplained muscle pain or weakness before starting Ezetimibe.
  • Use caution when taking Ezetimibe if you have a history of allergic reactions to this medication or its components.
  • Ezetimibe should be used with caution in individuals with severe kidney impairment.
  • Pregnant or breastfeeding women should consult with their healthcare provider before using Ezetimibe.

Dosage

The recommended dosage of Ezetimibe is typically 10 milligrams (mg) once daily, with or without food. It can be taken alone or in combination with other cholesterol-lowering medications, such as statins, as prescribed by your healthcare provider.

Side Effects

When taking Ezetimibe, here are some of the side effects you might experience:

  • Diarrhea
  • Fatigue
  • Muscle pain
  • Joint pain
  • Headache
  • Nausea
  • Abdominal pain
  • Allergic reactions (rash, itching, swelling)
  • Liver problems (rare, but can occur; symptoms may include yellowing of the skin or eyes, dark urine, or persistent nausea/vomiting)

 

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Rewards Program

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POINT VALUE

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