What is Bydureon?

Bydureon (Exenatide) is a prescription medication that falls under the category of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and manages type 2 diabetes.

 GLP-1 receptor agonists work by stimulating the GLP-1 receptors in the body, leading to various benefits that help regulate blood sugar levels. This drug class also includes medications like Byetta (exenatide) and Trulicity (dulaglutide). However, Bydureon is unique as it provides extended-release benefits, reducing the need for frequent injections compared to other GLP-1 RAs.

We administer Bydureon through an injection once a week, and its active ingredient is exenatide – a synthetic version of a naturally occurring hormone found in the saliva of the Gila monster lizard. This hormone lowers blood sugar levels by increasing insulin secretion, reducing the liver’s production of glucose, and slowing down stomach emptying.

Bydureon is a valuable medication in type 2 diabetes treatment. Ensure to take Bydureon as directed by your healthcare provider to receive the best possible benefits.

FDA Approval and Efficiency

BYDUREON (Exenatide) – Results from Clinical Trial and Side Effects

BYDUREON gained FDA approval based on findings from the DURATION-5 clinical trial that involved 252 adults diagnosed with type 2 diabetes. In this trial, the experts compared BYDUREON to BYETTA, and the results showed significant improvements in blood sugar control.

After 24 weeks of treatment, BYDUREON demonstrated a substantial reduction in HbA1c (a measure of blood sugar) by 1.6 percentage points, whereas BYETTA showed a reduction of 0.9 percentage points. Additionally, both treatment groups experienced weight loss, with BYDUREON users losing an average of 2.3 kg and BYETTA users losing 1.4 kg.

The most commonly reported side effect was nausea, but it occurred less frequently with BYDUREON (14%) compared to BYETTA (35%). Other side effects included diarrhea and injection-site redness. Researchers observed no significant incidents of low blood sugar, although minor episodes occurred in both groups when used in combination with sulfonylureas (12.5% versus 11.8%).

These results highlight the efficacy of BYDUREON in managing blood sugar levels and promoting weight loss in individuals with type 2 diabetes. It is essential to discuss potential side effects and any concerns with your healthcare provider before starting this treatment.

Dosage for Bydureon

The recommended dosage for Bydureon (exenatide extended-release) may vary based on individual patient requirements and the guidance of their healthcare provider. It is crucial to follow your doctor’s instructions and the prescribed dosing regimen. Here are some essential points to remember about Bydureon dosage:

Standard Dosage:

The typical starting dose for most patients is 2 milligrams (mg) of Bydureon once weekly.


Bydureon is available as a pre-filled, single-dose autoinjector or as a single-dose tray with a single-use, pre-filled pen. Your healthcare provider will demonstrate the proper technique for administering the injection, typically done subcutaneously (under the skin).


Inject Bydureon on the same day each week, regardless of meals.

Combination Therapy: 

Bydureon can be prescribed as a monotherapy or in combination with other anti-diabetes medications, such as metformin, sulfonylureas, or insulin. The specific medication combination will depend on your individual health needs.


While using Bydureon, your healthcare provider will regularly monitor your blood sugar levels and overall health to ensure that the medication is effectively managing your diabetes.

Remember, it is essential to consult with your healthcare provider about your specific condition and individual dosage requirements for Bydureon. Adhering to the prescribed dosage and regularly monitoring your diabetes will help ensure optimal treatment outcomes.

Side Effects of Bydureon

Bydureon (exenatide extended-release) may have both common and less common side effects. Common side effects are those that may occur in a significant number of patients. If you experience any of these side effects, it is crucial to inform your healthcare provider. Here are some common side effects associated with Bydureon:


Some individuals may experience mild to moderate nausea, especially when starting the medication. It usually improves over time.


Occasional episodes of vomiting may occur in some users, particularly during the initial weeks of treatment.


Bydureon can cause diarrhea as a common gastrointestinal side effect.

Injection Site Reactions:

Redness, itching, or a small bump at the injection site is possible but typically mild and transient.

Loss of Appetite: 

Bydureon can lead to a reduced appetite in some individuals, which can help promote weight management but may require adjustments to meal planning.


Bydureon does not typically cause low blood sugar (hypoglycemia) when used alone, but it may increase the risk of hypoglycemia when combined with other diabetes medications, especially sulfonylureas or insulin.

It is essential to discuss these potential side effects and other concerns with your healthcare provider before starting Bydureon. Regularly monitoring your health and promptly reporting any adverse reactions can help ensure optimal treatment outcomes.

Interactions with Exenatide

Interactions with exenatide can occur, potentially affecting how the medication works. Here’s what you need to know:

Oral Diabetes Medications: 

Exenatide may change how your body absorbs oral diabetes medications. Your doctor might need to adjust the dose to avoid low blood sugar.

Antibiotics and Birth Control Pills: 

Doctors recommend taking antibiotics or birth control pills by mouth at least an hour apart from exenatide.

Blood Thinners: 

If you are taking blood thinners such as warfarin, your doctor may need to monitor your blood while taking exenatide closely.

Stomach Medications: 

Certain stomach medications can interact with exenatide, so inform your doctor if you take any.

Herbal Supplements: 

If you take herbs or other supplements, your healthcare provider should be aware of them, too.


It is important to note that alcohol can affect your blood sugar levels. If you drink, do so in moderation and be careful about the timing of your Bydureon injections.

In summary, Bydureon, powered by exenatide, offers a convenient weekly solution to help manage type 2 diabetes. While it simplifies treatment, it is crucial to work closely with your healthcare provider to address potential side effects and interactions. Bydureon can be an essential part of your diabetes management plan, promoting a healthy lifestyle and enhancing your quality of life.