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Taltz 

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Description

Uses of Taltz

Taltz injection is used to treat plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis, which are all autoimmune disorders. Taltz works by reducing inflammation, which helps improve the symptoms of these conditions.

Precautions and Warnings

This medicine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, sweating, muscle pain, weight loss, skin sores, shortness of breath, cough with red or pink mucus, increased urination, or painful urination.Your doctor may perform tests to make sure you do not have tuberculosis or other infectionsSerious hypersensitivity reactions can occur with this medicine. If an allergic reaction occurs discontinue treatment immediately and initiate appropriate therapy. Taltz injection is contraindicated in patients who have had previous serious hypersensitivity reaction to this medicine.You should not have live vaccines while being treated with this medicine.Crohn’s disease and ulcerative colitis, including exacerbations have occurred during treatment with this medicine. Patients should be monitored closely when this medicine is prescribed to patients with inflammatory bowel disease (IBD). If IBD develops and appropriate medical management should be started.You should not use this medicine if you are allergic to the active ingredient ixekizumab, or any of the inactive ingredients contained in this medicine. To check for a complete list of ingredients, see the Ingredients section below.To make sure Taltz injection is safe for you, tell your doctor if you have:
  • an active or recent infection;
  • Crohn’s disease, ulcerative colitis;
  • tuberculosis (or if you have close contact with someone who has tuberculosis): or.
  • if you have recently received or are scheduled to receive a vaccine.
Your doctor may perform tests to make sure you do not have tuberculosis or other infections.Make sure you are up to date with all age-appropriate vaccinations before you start treatment with this medicine.Tell your doctor if you are pregnant or plan to become pregnant . It is not known if Taltz can harm your unborn baby. If you are pregnant or you become pregnant, your name may be listed on a pregnancy registry to track the effects of ixekizumab on the baby. The purpose of this registry is to collect information about the health of you and your baby.Tell your doctor if you are breastfeeding or planning to breastfeed. It is not known whether this medicine passes into breast milk or if it could harm a nursing baby.

Dosage

Usual Adult Taltz Dose for Plaque Psoriasis – 160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg at Weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks.Usual Pediatric Taltz Dose for Plaque Psoriasis
  • Weight less than 25 kg. Dose 40 mg subcutaneously at Week 0, followed by 20mg every 4 weeks thereafter.
  • Weight 25 to 50 kg. Dose 80 mg subcutaneously at Week 0, followed by 40mg every 4 weeks thereafter.
  • Weight greater than 50 kg. Dose 160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80mg every 4 weeks thereafter.
  • Use: For the treatment of pediatric patients from 6 years of age to less than 18 years of age with moderate-to-severe plaque psoriasis
Usual Adult Taltz Dose for Psoriatic Arthritis
  • 160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg every 4 weeks
  • For psoriatic arthritis patients with coexistent moderate-to-severe plaque psoriasis, use the dosing regimen for plaque psoriasis.
  • This drug may be administered alone or in combination with a conventional disease-modifying antirheumatic drug (cDMARD) (e.g., methotrexate).
  • Use: For the treatment of adult patients with active psoriatic arthritis
Usual Adult Taltz Dose for Ankylosing Spondylitis – 160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg every 4 weeks.Usual Adult Taltz Dose for Non-radiographic Axial Spondyloarthritis – 160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg every 4 weeks.

Side Effects

The more common side effects* of Taltz can include:

  • injection site reactions (discoloration and soreness around the injection area)
  • upper respiratory infections, such as the common cold or the flu
  • nausea
  • fungal infections, such as athlete’s foot
  • conjunctivitis (pink eye)

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